KR20140093291A - AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘 - Google Patents

AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘 Download PDF

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KR20140093291A
KR20140093291A KR1020147017714A KR20147017714A KR20140093291A KR 20140093291 A KR20140093291 A KR 20140093291A KR 1020147017714 A KR1020147017714 A KR 1020147017714A KR 20147017714 A KR20147017714 A KR 20147017714A KR 20140093291 A KR20140093291 A KR 20140093291A
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South Korea
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methyl
mmol
alkyl
cyclopenta
dihydro
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Korean (ko)
Inventor
이안 에스. 미첼
제임스 에프. 블레이크
루이 수
니콜라스 씨. 켈런
덩밍 씨아오
키스 리 스펜서
조우지프 알. 벤칙
준 리앙
브라이언 사피나
비롱 장
크리스틴 샤보트
스티븐 두
엘리 엠. 월리스
애너 엘. 밴카
스티븐 티. 슐라츠터
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어레이 바이오파마 인크.
제넨테크, 인크.
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Application filed by 어레이 바이오파마 인크., 제넨테크, 인크. filed Critical 어레이 바이오파마 인크.
Publication of KR20140093291A publication Critical patent/KR20140093291A/ko
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KR1020147017714A 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘 Ceased KR20140093291A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
US60/818,718 2006-07-06
PCT/US2007/072885 WO2008006040A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Related Parent Applications (1)

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KR1020137031899A Division KR101578877B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘

Related Child Applications (1)

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KR1020157010625A Division KR20150051240A (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘

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KR1020147017714A Ceased KR20140093291A (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020127011042A Active KR101495408B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020157010625A Ceased KR20150051240A (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020137031899A Active KR101578877B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020097002395A Active KR101178672B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘

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KR1020127011042A Active KR101495408B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020157010625A Ceased KR20150051240A (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020137031899A Active KR101578877B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘
KR1020097002395A Active KR101178672B1 (ko) 2006-07-06 2007-07-05 AKT 단백질 키나제 억제제로서의 히드록실화 및 메톡실화 시클로펜타[d]피리미딘

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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
CA2656566C (en) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
ATE523499T1 (de) 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
WO2009006567A2 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101918373B (zh) 2007-07-05 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
TW200940542A (en) 2008-01-09 2009-10-01 Array Biopharma Inc Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101970415A (zh) * 2008-01-09 2011-02-09 阵列生物制药公司 作为AKT蛋白激酶抑制剂的5H-环戊二烯并[d]嘧啶
ES2422733T3 (es) * 2008-01-09 2013-09-13 Array Biopharma Inc Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT
MX2013007171A (es) * 2010-12-23 2013-11-04 Genentech Inc Inductor de autofagia y terapia de combinacion inhibidora para el tratamiento de neoplasias.
PL2694959T3 (pl) * 2011-04-01 2020-05-18 Genentech, Inc. Biomarkery do przewidywania wrażliwości w leczeniu nowotworu złośliwego
RU2013148817A (ru) 2011-04-01 2015-05-10 Дженентек, Инк. Комбинации соединений-ингибиторов акт и мек и способы их применения
WO2012135781A1 (en) * 2011-04-01 2012-10-04 Genentech, Inc. Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
EP2850200A1 (en) * 2012-05-17 2015-03-25 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
HRP20180948T1 (hr) 2012-05-17 2018-08-10 Genentech, Inc. Postupak za proizvodnju aminokiselinskih spojeva
ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
KR102678074B1 (ko) 2012-05-17 2024-06-26 제넨테크, 인크. 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법
US9416110B2 (en) 2012-05-17 2016-08-16 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
US20150258127A1 (en) 2012-10-31 2015-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
JP2016502974A (ja) * 2012-12-07 2016-02-01 ザ ジェネラル ホスピタル コーポレイション Pi3k/akt阻害剤化合物とher3/egfr阻害剤化合物との組み合わせ及び高増殖性疾患の治療におけるその使用
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
SI3068770T1 (sl) 2013-11-15 2020-02-28 F. Hoffmann-La Roche Ag Postopki za pripravo pirimidinilciklopentanskih spojin
RU2732404C2 (ru) * 2014-09-26 2020-09-16 Ф. Хоффманн-Ля Рош Аг СПОСОБЫ ПОЛУЧЕНИЯ (ЦИКЛОПЕНТИЛ[d]ПИРИМИДИН-4-ИЛ)ПИПЕРАЗИНОВЫХ СОЕДИНЕНИЙ
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
KR20190084063A (ko) 2016-10-28 2019-07-15 이칸 스쿨 오브 메디슨 엣 마운트 시나이 Ezh2-매개성 암 치료용 조성물 및 방법
JP2021515013A (ja) * 2018-03-06 2021-06-17 アイカーン スクール オブ メディスン アット マウント シナイ セリンスレオニンキナーゼ(akt)分解/破壊化合物および使用方法
EP3810145A4 (en) 2018-06-21 2022-06-01 Icahn School of Medicine at Mount Sinai Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use
TWI719765B (zh) 2018-12-19 2021-02-21 美商建南德克公司 使用包含akt抑制劑、紫杉烷及pd-l1抑制劑之組合療法之乳癌治療
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
AU2020214258B2 (en) 2019-01-29 2025-08-28 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. AKT inhibitor
WO2020201073A1 (en) 2019-03-29 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of keloid, hypertrophic scars and/or hyperpigmentation disorders
JP7667742B2 (ja) * 2019-04-09 2025-04-23 ダナ-ファーバー キャンサー インスティテュート,インコーポレイテッド Atp競合性akt阻害剤gdc-0068とe3リガーゼリガンドとの結合によるaktの分解および使用方法
JP7503851B2 (ja) 2019-05-06 2024-06-21 アイカーン スクール オブ メディスン アット マウント シナイ Hpk1の分解剤としてのヘテロ二官能性化合物
CN115397815B (zh) * 2020-03-17 2024-06-14 江苏恒瑞医药股份有限公司 稠合二环类衍生物、其制备方法及其在医药上的应用
US12103924B2 (en) 2020-06-01 2024-10-01 Icahn School Of Medicine At Mount Sinai Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use
CN115916758A (zh) 2020-06-16 2023-04-04 豪夫迈·罗氏有限公司 用于制备羟基化环戊基嘧啶化合物的方法
US20230286979A1 (en) 2020-07-22 2023-09-14 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Salt of dihydropyrido[2,3-d]pyrimidinone derivative, preparation method therefor, and use thereof
TWI750905B (zh) * 2020-11-19 2021-12-21 財團法人國家衛生研究院 噻唑化合物作為蛋白質激酶抑制劑
KR102689151B1 (ko) * 2021-09-06 2024-07-29 연세대학교 산학협력단 Akt 신호경로 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물
WO2023043869A1 (en) * 2021-09-15 2023-03-23 Teva Pharmaceuticals International Gmbh Solid state forms of ipatasertib citrate
CN113788834B (zh) * 2021-09-18 2022-11-29 河南奥思恩医药科技有限公司 2,4-二氯-6,7-二氢-5H-吡咯并[3,4-d]嘧啶盐酸盐的制备方法
CN117677614A (zh) * 2021-12-17 2024-03-08 中国医药研究开发中心有限公司 具有akt激酶抑制活性的杂环化合物及其制备方法和医药用途
JP2025510910A (ja) 2022-03-31 2025-04-15 アストラゼネカ・アクチエボラーグ 癌の処置のための、akt阻害剤との組み合わせにおける上皮成長因子受容体(egfr)チロシンキナーゼ阻害剤
IL320302A (en) 2022-10-17 2025-06-01 Astrazeneca Ab SERD combinations for cancer treatment
WO2024100236A1 (en) 2022-11-11 2024-05-16 Astrazeneca Ab Combination therapies for the treatment of cancer
CN120712346A (zh) 2023-01-31 2025-09-26 豪夫迈·罗氏有限公司 具有增加的酮还原酶活性的突变型酮还原酶以及涉及其的方法和用途
EP4643858A1 (en) 2024-04-29 2025-11-05 Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical composition for the treatment of uterine disease

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
NL7112938A (enExample) * 1970-09-30 1972-04-05
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
BR9807100A (pt) * 1997-01-08 2000-04-25 Hoffamann La Roche Ag F Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos
ES2152902B1 (es) * 1999-07-27 2001-08-16 Medichem Sa Procedimiento de obtencion de venlafaxina
PT1315715E (pt) * 2000-08-18 2008-10-30 Millennium Pharm Inc Derivados de quianazolina utilizados como inibidores de quinase
WO2002022605A1 (en) * 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002083083A2 (en) * 2001-03-30 2002-10-24 King Pharmaceuticals, Inc. Pharmaceutically active compounds and methods of use
US20050107404A1 (en) * 2001-12-06 2005-05-19 Fraley Mark E. Mitotic kinesin inhibitors
EP1470121B1 (en) * 2002-01-23 2012-07-11 Bayer HealthCare LLC Pyrimidine derivatives as rho-kinase inhibitors
TW200306819A (en) * 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
NZ590160A (en) 2003-11-21 2012-07-27 Array Biopharma Inc AKT protein kinase inhibitors
WO2005105780A2 (en) * 2004-04-28 2005-11-10 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
WO2005113762A1 (en) 2004-05-18 2005-12-01 Pfizer Products Inc. CRYSTAL STRUCTURE OF PROTEIN KINASE B-α (AKT-1) AND USES THEREOF
CA2600745A1 (en) * 2005-03-03 2006-09-08 The Burnham Institute For Medical Research Screening methods for protein kinase b inhibitors employing virtual docking approaches and compounds and compositions discovered thereby
ATE532789T1 (de) * 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
ATE523499T1 (de) * 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы

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