BR9807100A - Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos - Google Patents
Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicosInfo
- Publication number
- BR9807100A BR9807100A BR9807100-9A BR9807100A BR9807100A BR 9807100 A BR9807100 A BR 9807100A BR 9807100 A BR9807100 A BR 9807100A BR 9807100 A BR9807100 A BR 9807100A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- benzo
- isoindoles
- isoquinolines
- stroke
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Patente de Invenção: <B>"BENZO[E]ISOINDóIS E BENZO[H]SOQUINOLINAS TRICìCLICOS"<D>. A presente invenção refere-se a novas benzo[e]-isoindóis e benzo[h]isoquinolinas. Uma vez que os compostos de acordo com a invenção podem ligar-se a receptores de serotonina (5HT~ 2~), eles são especialmente adequados para o tratameno ou prevenção de distúbios nervosos centrais tais como depressões, distúrbios bipolares, estados de ansiedade, distúbios do sono e sexual, psicose, esquizofrenia, enxaqueca e outras condições associadas com dor cefálica ou dor de uma espécie dirente, distúrbios de personalidade ou distúbios compulsivos obsessivos, fobias sociais ou ataques de pânico, distúrbios orgânicos mentais, distúrbios menstais na infância, agressividade, distúrbios da memória relacionados com a idade e distúrbios de comportamento, vício, obesidade, bulimia, etc., dano do sistema nervoso causado por trauma, acidente vascular cerebral, doenças neurodegenerativas, etc.; distúrbios cardiovasculares, tais como hipertensão, trombose, acidente vascular cerebral, etc; e distúrbios gastrintestinais tais como disfunção da motilidade do trato gastrintestinal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97100172 | 1997-01-08 | ||
PCT/EP1998/000043 WO1998030546A1 (en) | 1997-01-08 | 1998-01-07 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9807100A true BR9807100A (pt) | 2000-04-25 |
Family
ID=26145159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9807100-9A BR9807100A (pt) | 1997-01-08 | 1998-01-07 | Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0958285B1 (pt) |
JP (1) | JP3297058B2 (pt) |
AT (1) | ATE257470T1 (pt) |
AU (1) | AU742735B2 (pt) |
BR (1) | BR9807100A (pt) |
CA (1) | CA2276098C (pt) |
DE (1) | DE69820989T2 (pt) |
DK (1) | DK0958285T3 (pt) |
WO (1) | WO1998030546A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010073153A (ko) | 1998-09-18 | 2001-07-31 | 제임스 에이. 아노 | 녹내장 치료용의 세로토닌성 5ht2 작용제 |
US6780862B2 (en) | 2000-12-20 | 2004-08-24 | Bristol-Myers Squibb Pharma Company | Aryl and aminoaryl substituted serotonin receptor agonist and antagonist ligands |
JP2004115510A (ja) * | 2002-09-05 | 2004-04-15 | Toray Fine Chemicals Co Ltd | ピペラジン誘導体の製造方法 |
WO2006022420A1 (ja) | 2004-08-25 | 2006-03-02 | Takeda Pharmaceutical Company Limited | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
EP1796663B1 (en) * | 2004-09-03 | 2011-05-04 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
EP2742936A1 (en) | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CN100402534C (zh) * | 2006-11-09 | 2008-07-16 | 东南大学 | 一种三环类化合物及其在制药中的应用 |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
WO2011071136A1 (ja) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH504438A (de) * | 1968-05-27 | 1971-03-15 | Sandoz Ag | Verfahren zur Herstellung von 1,2,3,4,4a,5,6,10b-Octahydrobenz(h)isochinolin-6-on |
US4678791A (en) * | 1985-05-07 | 1987-07-07 | Pennwalt Corporation | 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression |
US5180733A (en) * | 1990-03-30 | 1993-01-19 | Abbott Laboratories | Biogenic amine uptake inhibitors |
-
1998
- 1998-01-07 AU AU59866/98A patent/AU742735B2/en not_active Ceased
- 1998-01-07 EP EP98902982A patent/EP0958285B1/en not_active Expired - Lifetime
- 1998-01-07 JP JP53053498A patent/JP3297058B2/ja not_active Expired - Fee Related
- 1998-01-07 AT AT98902982T patent/ATE257470T1/de not_active IP Right Cessation
- 1998-01-07 DE DE69820989T patent/DE69820989T2/de not_active Expired - Fee Related
- 1998-01-07 WO PCT/EP1998/000043 patent/WO1998030546A1/en active IP Right Grant
- 1998-01-07 CA CA002276098A patent/CA2276098C/en not_active Expired - Fee Related
- 1998-01-07 BR BR9807100-9A patent/BR9807100A/pt not_active Application Discontinuation
- 1998-01-07 DK DK98902982T patent/DK0958285T3/da active
Also Published As
Publication number | Publication date |
---|---|
JP2000507965A (ja) | 2000-06-27 |
DK0958285T3 (da) | 2004-05-17 |
EP0958285B1 (en) | 2004-01-07 |
WO1998030546A1 (en) | 1998-07-16 |
DE69820989D1 (de) | 2004-02-12 |
AU5986698A (en) | 1998-08-03 |
AU742735B2 (en) | 2002-01-10 |
EP0958285A1 (en) | 1999-11-24 |
DE69820989T2 (de) | 2004-12-09 |
JP3297058B2 (ja) | 2002-07-02 |
CA2276098C (en) | 2007-05-08 |
ATE257470T1 (de) | 2004-01-15 |
CA2276098A1 (en) | 1998-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2153937A1 (en) | Tricyclic pyrazole derivatives | |
CA2132887A1 (en) | Tricyclic 1-aminoethylpyrrole-derivatives | |
BR9807100A (pt) | Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos | |
BR0309303A (pt) | Moduladores de receptores de 5ht2c | |
RU94037964A (ru) | Производные 1-амино-этилиндола | |
BRPI0515528A (pt) | n-metil hidroxietilamina úteis no tratamento de condições do sistema nervoso central | |
ATE349211T1 (de) | Dual bindende acetylcholinesterase inhibitoren zur behandlung von alzheimer | |
WO2006019886A3 (en) | Pyrrolo(oxo)isoquinolines as 5ht ligands | |
DE69929464D1 (de) | Zyklische polyamine zur behandlung der thrombozytopenie | |
PE20010575A1 (es) | Derivados de indol y su uso como ligandos del receptor 5ht2 | |
TR199901586T2 (xx) | Trisiklik benzo[e] izoindoller ve benzo[h] izokinolinler | |
ATE279418T1 (de) | Antidepressive indoltetrahydropyridin-derivate von 2,3-dihydro-7h(1,4)dioxino(2,3-e)indol | |
DE60213576D1 (de) | ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN | |
ECSP982363A (es) | BENZO (e) ISOINDOLES TRICICLICOS Y BENZO (h)ISOQUINOLINAS | |
ES2183092T3 (es) | Proceso para la preparacion de iohexol cristalino purificado. | |
DE60004473D1 (de) | Verwendung von gaba-b rezeptor liganden zur herstellungen von medikamenten zur behandlung von neurodegenerativen erkrankungen | |
ATE287404T1 (de) | Diazabicyclo (2.2.1) heptanderivate | |
CR7203A (es) | 5-sustituidas-2-arilpiridinas como moduladores del factor 1 de liberacion de corticotropina | |
RU2003126422A (ru) | Спсооб лечения сладж-синдрома у больных хроническим бекскаменным холецистиом |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM O ART. 8O DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |