KR20140086975A - 실리카 구상체 및 어피니티 담체 - Google Patents

실리카 구상체 및 어피니티 담체 Download PDF

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Publication number
KR20140086975A
KR20140086975A KR1020147010424A KR20147010424A KR20140086975A KR 20140086975 A KR20140086975 A KR 20140086975A KR 1020147010424 A KR1020147010424 A KR 1020147010424A KR 20147010424 A KR20147010424 A KR 20147010424A KR 20140086975 A KR20140086975 A KR 20140086975A
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South Korea
Prior art keywords
silica
particle diameter
carrier
protein
spherical body
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Ceased
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KR1020147010424A
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English (en)
Korean (ko)
Inventor
히로요시 미야하라
료우 나카시마
겐지 히가시
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에이지씨 에스아이테크 가부시키가이샤
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Publication of KR20140086975A publication Critical patent/KR20140086975A/ko
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28019—Spherical, ellipsoidal or cylindrical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28076—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being more than 1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3085—Chemical treatments not covered by groups B01J20/3007 - B01J20/3078
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
    • C01B33/187—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates
    • C01B33/193—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Silicon Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
KR1020147010424A 2011-10-28 2012-10-26 실리카 구상체 및 어피니티 담체 Ceased KR20140086975A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2011-237204 2011-10-28
JP2011237204 2011-10-28
PCT/JP2012/077788 WO2013062105A1 (ja) 2011-10-28 2012-10-26 シリカ球状体及びアフィニティ担体

Publications (1)

Publication Number Publication Date
KR20140086975A true KR20140086975A (ko) 2014-07-08

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KR1020147010424A Ceased KR20140086975A (ko) 2011-10-28 2012-10-26 실리카 구상체 및 어피니티 담체

Country Status (7)

Country Link
US (1) US9192914B2 (enExample)
EP (1) EP2772466A4 (enExample)
JP (1) JP6002142B2 (enExample)
KR (1) KR20140086975A (enExample)
CN (1) CN103906708B (enExample)
IN (1) IN2014DN03278A (enExample)
WO (1) WO2013062105A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY178616A (en) 2012-09-17 2020-10-19 Grace W R & Co Chromatography media and devices
JP6241252B2 (ja) * 2013-12-16 2017-12-06 旭硝子株式会社 球状シリカの製造方法
JP2015113276A (ja) * 2013-12-16 2015-06-22 旭硝子株式会社 球状シリカ及びその製造方法
PL3094390T3 (pl) 2014-01-16 2021-12-06 W.R. Grace & Co. - Conn. Nośniki do chromatografii powinowactwa i urządzenia do chromatografii
PL3137209T3 (pl) 2014-05-02 2023-01-02 W.R. Grace & Co. - Conn. Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego
US10695744B2 (en) 2015-06-05 2020-06-30 W. R. Grace & Co.-Conn. Adsorbent biprocessing clarification agents and methods of making and using the same
US11835501B2 (en) 2015-07-13 2023-12-05 Sartorius Stedim Chromatography Systems Ltd. Optimizing operating binding capacity for a multiple column chromatography process
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
CN108430922B (zh) * 2015-12-30 2020-05-08 高露洁-棕榄公司 用于细菌聚集的粘蛋白包被的二氧化硅
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3950124A4 (en) * 2019-03-29 2023-01-04 Sumitomo Chemical Company Limited INORGANIC POROUS SUPPORT AND METHOD FOR PRODUCTION OF NUCLEIC ACIDS THEREWITH
EP3950695A4 (en) 2019-03-29 2023-01-25 Sumitomo Chemical Company, Limited PROCEDURE FOR PRODUCTION OF RNA
WO2020202951A1 (ja) * 2019-03-29 2020-10-08 住友化学株式会社 無機多孔質担体、及びこれを用いた核酸の製造方法
WO2020202950A1 (ja) * 2019-03-29 2020-10-08 住友化学株式会社 無機多孔質担体及びこれを用いた核酸の製造方法
US12377409B2 (en) 2019-03-29 2025-08-05 Sumitomo Chemical Company, Limited Inorganic porous carrier, and production method for nucleic acid using same
EP4151597A4 (en) * 2020-05-13 2024-07-17 Sumitomo Chemical Company, Limited Inorganic porous substrate, inorganic porous support, and nucleic acid production method
US20220354757A1 (en) * 2021-05-04 2022-11-10 Momentive Performance Materials Japan Llc Method for producing silica particles and their use in cosmetic compositions
US12186450B2 (en) 2021-06-21 2025-01-07 Osteonovus Llc Composition of substantially spherical granule for bone regeneration
JPWO2023127481A1 (enExample) * 2021-12-27 2023-07-06
KR20250022037A (ko) 2022-06-13 2025-02-14 에이지씨 가부시키가이샤 구상 실리카 분말의 제조 방법
CN119384266A (zh) 2022-06-13 2025-01-28 Ａｇｃ株式会社 化妆品用二氧化硅粉末和化妆品
WO2025173342A1 (ja) * 2024-02-13 2025-08-21 Jsr株式会社 Ｆｃ融合タンパク質を精製するためのクロマトグラフィー用担体、及びそれを用いたＦｃ融合タンパク質の精製方法
WO2025225709A1 (ja) * 2024-04-26 2025-10-30 株式会社ニッスイ クロマトグラフィー用充填剤
WO2025249501A1 (ja) * 2024-05-30 2025-12-04 株式会社ダイセル 分離剤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006225226A (ja) * 2005-02-21 2006-08-31 Asahi Glass Co Ltd 球状シリカ及びその製造方法
JP2007076941A (ja) * 2005-09-13 2007-03-29 Tosoh Corp 多孔質球状シリカ及びその製造方法
JP2007238426A (ja) * 2006-02-13 2007-09-20 Asahi Glass Si-Tech Co Ltd 大細孔径多孔質シリカゲルの細孔物性の調整方法及び得られた大細孔径多孔質シリカゲル
JP2011001336A (ja) * 2009-06-22 2011-01-06 Agc Si-Tech Co Ltd 新規なプロテインａ固定化担体の製造方法
JP2011173779A (ja) * 2010-01-26 2011-09-08 Sakai Chem Ind Co Ltd シリカ粒子とその製造方法、及びそれを含む樹脂組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7613414A (nl) 1976-12-02 1978-06-06 Shell Int Research Behandeling van silica.
US5084559A (en) 1987-03-27 1992-01-28 Repligen Corporation Protein a domain mutants
JPH0699132B2 (ja) 1989-06-16 1994-12-07 ダイソー株式会社 大細孔径シリカゲルの製造法
JPH07198701A (ja) * 1993-11-26 1995-08-01 Ngk Insulators Ltd 低圧高速液体クロマトグラフィー用カラム、低圧高速液体クロマトグラフィー用カラム装置及び同カラム装置の使用方法
JP3454554B2 (ja) * 1993-12-28 2003-10-06 水澤化学工業株式会社 非晶質シリカ粒状体及びその製法
JPH07291754A (ja) * 1994-04-19 1995-11-07 Mizusawa Ind Chem Ltd 多孔質シリカ成型体及びその製法
JP4193626B2 (ja) 2002-07-15 2008-12-10 旭硝子株式会社 無機質球状体の製造方法
WO2004101139A1 (ja) * 2003-05-13 2004-11-25 Asahi Glass Company, Limited 無機質球状体の製造方法
JP2008120633A (ja) * 2006-11-13 2008-05-29 Shiseido Co Ltd 球状多孔質シリカ、その製造方法及びカラム充填剤
SG149759A1 (en) 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
US8357628B2 (en) * 2008-08-29 2013-01-22 Agilent Technologies, Inc. Inorganic/organic hybrid totally porous metal oxide particles, methods for making them and separation devices using them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006225226A (ja) * 2005-02-21 2006-08-31 Asahi Glass Co Ltd 球状シリカ及びその製造方法
JP2007076941A (ja) * 2005-09-13 2007-03-29 Tosoh Corp 多孔質球状シリカ及びその製造方法
JP2007238426A (ja) * 2006-02-13 2007-09-20 Asahi Glass Si-Tech Co Ltd 大細孔径多孔質シリカゲルの細孔物性の調整方法及び得られた大細孔径多孔質シリカゲル
JP2011001336A (ja) * 2009-06-22 2011-01-06 Agc Si-Tech Co Ltd 新規なプロテインａ固定化担体の製造方法
JP2011173779A (ja) * 2010-01-26 2011-09-08 Sakai Chem Ind Co Ltd シリカ粒子とその製造方法、及びそれを含む樹脂組成物

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US9192914B2 (en) 2015-11-24
JP6002142B2 (ja) 2016-10-05
JPWO2013062105A1 (ja) 2015-04-02
IN2014DN03278A (enExample) 2015-05-22
CN103906708B (zh) 2015-09-23
CN103906708A (zh) 2014-07-02
US20140235435A1 (en) 2014-08-21
EP2772466A4 (en) 2015-12-09
EP2772466A1 (en) 2014-09-03
WO2013062105A1 (ja) 2013-05-02

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