IN2014DN03278A - - Google Patents

Download PDF

Info

Publication number
IN2014DN03278A
IN2014DN03278A IN3278DEN2014A IN2014DN03278A IN 2014DN03278 A IN2014DN03278 A IN 2014DN03278A IN 3278DEN2014 A IN3278DEN2014 A IN 3278DEN2014A IN 2014DN03278 A IN2014DN03278 A IN 2014DN03278A
Authority
IN
India
Prior art keywords
particle diameter
mercury porosimetry
carrier
micropore
average
Prior art date
Application number
Inventor
Hiroyoshi Miyahara
Ryou Nakashima
Kenji Higashi
Original Assignee
Agc Si Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agc Si Tech Co Ltd filed Critical Agc Si Tech Co Ltd
Publication of IN2014DN03278A publication Critical patent/IN2014DN03278A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28019—Spherical, ellipsoidal or cylindrical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28076—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being more than 1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3085—Chemical treatments not covered by groups B01J20/3007 - B01J20/3078
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
    • C01B33/187—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates
    • C01B33/193—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Silicon Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided is an affinity carrier having a low pressure loss and a high binding capacity even when the linear flow rate of a solution passing through the carrier is fast. Also provided is a silica spherical body having (a) according to laser light scattering an average particle diameter of 30 to 40 µm (b)according to measurement by a Coulter counter a ratio (D10/D90) of 1.50 or less where D10 is 10% and D90 is 90% beginning from the smallest cumulative volume of the particle diameter distribution and (c) according to mercury porosimetry an average micropore diameter of between 85 to 115 nm and a micropore volume of 1.5 mL/g or greater as determined by mercury porosimetry.
IN3278DEN2014 2011-10-28 2012-10-26 IN2014DN03278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011237204 2011-10-28
PCT/JP2012/077788 WO2013062105A1 (en) 2011-10-28 2012-10-26 Silica spherical body and affinity carrier

Publications (1)

Publication Number Publication Date
IN2014DN03278A true IN2014DN03278A (en) 2015-05-22

Family

ID=48167929

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3278DEN2014 IN2014DN03278A (en) 2011-10-28 2012-10-26

Country Status (7)

Country Link
US (1) US9192914B2 (en)
EP (1) EP2772466A4 (en)
JP (1) JP6002142B2 (en)
KR (1) KR20140086975A (en)
CN (1) CN103906708B (en)
IN (1) IN2014DN03278A (en)
WO (1) WO2013062105A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015005937A2 (en) 2012-09-17 2017-07-04 Grace W R & Co chromatographic media and devices
JP6241252B2 (en) * 2013-12-16 2017-12-06 旭硝子株式会社 Method for producing spherical silica
JP2015113276A (en) * 2013-12-16 2015-06-22 旭硝子株式会社 Spherical silica and method for manufacturing the same
JP6853670B2 (en) * 2014-01-16 2021-04-07 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ Affinity Chromatography Medium and Chromatography Devices
CN107847907A (en) 2014-05-02 2018-03-27 格雷斯公司 Functionalised supports' material and preparation and the method using functionalised supports' material
PL3302784T3 (en) 2015-06-05 2022-01-17 W.R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same
US11835501B2 (en) 2015-07-13 2023-12-05 Sartorius Stedim Chromatography Systems Ltd. Optimizing operating binding capacity for a multiple column chromatography process
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
WO2017117500A1 (en) * 2015-12-30 2017-07-06 Colgate-Palmolive Company Mucin coated silica for bacterial aggregation
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3950126A4 (en) * 2019-03-29 2023-11-01 Sumitomo Chemical Company Limited Inorganic porous carrier and method for producing nucleic acids using same
CN113646083B (en) 2019-03-29 2024-06-07 住友化学株式会社 Inorganic porous carrier and method for producing nucleic acid using same
WO2020202952A1 (en) * 2019-03-29 2020-10-08 住友化学株式会社 Inorganic porous carrier, and production method for nucleic acid using same
US20220106347A1 (en) * 2019-03-29 2022-04-07 Sumitomo Chemical Company, Limited Porous inorganic carrier and method for producing nucleic acid using same
EP4151597A1 (en) * 2020-05-13 2023-03-22 Sumitomo Chemical Company, Limited Inorganic porous substrate, inorganic porous support, and nucleic acid production method
US20220401620A1 (en) * 2021-06-21 2022-12-22 Osteonovus Llc Composition of substantially spherical granule for bone regeneration
WO2023127481A1 (en) * 2021-12-27 2023-07-06 株式会社トクヤマ Spherical surface-treated silica aerogel and production method therefor

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7613414A (en) 1976-12-02 1978-06-06 Shell Int Research TREATMENT OF SILICA.
US5084559A (en) 1987-03-27 1992-01-28 Repligen Corporation Protein a domain mutants
JPH0699132B2 (en) 1989-06-16 1994-12-07 ダイソー株式会社 Large pore size silica gel manufacturing method
JPH07198701A (en) * 1993-11-26 1995-08-01 Ngk Insulators Ltd Column and column device for low-pressure high-precision liquid chromatography and method for using column device
JP3454554B2 (en) * 1993-12-28 2003-10-06 水澤化学工業株式会社 Amorphous silica granules and production method thereof
JPH07291754A (en) * 1994-04-19 1995-11-07 Mizusawa Ind Chem Ltd Porous silica molding and production thereof
JP4193626B2 (en) 2002-07-15 2008-12-10 旭硝子株式会社 Method for producing inorganic spherical body
WO2004101139A1 (en) * 2003-05-13 2004-11-25 Asahi Glass Company, Limited Process for producing inorganic sphere
JP2006225226A (en) * 2005-02-21 2006-08-31 Asahi Glass Co Ltd Spherical silica and its manufacturing method
JP2007076941A (en) * 2005-09-13 2007-03-29 Tosoh Corp Porous spherical silica and its producing method
JP5068978B2 (en) 2006-02-13 2012-11-07 Ａｇｃエスアイテック株式会社 Method for adjusting pore properties of porous silica gel with large pore diameter and obtained porous silica gel with large pore diameter
JP2008120633A (en) * 2006-11-13 2008-05-29 Shiseido Co Ltd Spherical porous silica, its manufacturing process and column packing material
SG149759A1 (en) 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
US8357628B2 (en) * 2008-08-29 2013-01-22 Agilent Technologies, Inc. Inorganic/organic hybrid totally porous metal oxide particles, methods for making them and separation devices using them
JP2011001336A (en) 2009-06-22 2011-01-06 Agc Si-Tech Co Ltd Method for producing new protein a immobilization carrier
JP2011173779A (en) * 2010-01-26 2011-09-08 Sakai Chem Ind Co Ltd Silica particles, process for production of same, and resin composition containing same

Also Published As

Publication number Publication date
CN103906708A (en) 2014-07-02
WO2013062105A1 (en) 2013-05-02
JP6002142B2 (en) 2016-10-05
JPWO2013062105A1 (en) 2015-04-02
KR20140086975A (en) 2014-07-08
US9192914B2 (en) 2015-11-24
EP2772466A4 (en) 2015-12-09
US20140235435A1 (en) 2014-08-21
CN103906708B (en) 2015-09-23
EP2772466A1 (en) 2014-09-03

Similar Documents

Publication Publication Date Title
IN2014DN03278A (en)
MY183615A (en) Inhalable pharmaceutical compositions
BR112016029544A2 (en) porous silica particles, method of manufacture and cosmetic product containing the same
MY187815A (en) Magnetic toner
MX341663B (en) Organic compound nanopowder, production method therefor, and suspension.
RS51632B (en) Pulverulent lime composition, method for the production thereof, and use of the same
MY157041A (en) Polishing composition
MX347462B (en) Aqueous coating composition and anti-glare coating formed thereform.
MY161484A (en) Polishing composition
BR112012028077A2 (en) polyethylene powders and porous articles thereof
MX360032B (en) Granular functionalized silica, process for preparation thereof and use thereof.
PH12014501852B1 (en) Sunscreen composition
UA115183C2 (en) Tobacco material, tobacco product to which tobacco material is added, and method for producing tobacco material
GB201309998D0 (en) Re-calibration of instruments
IN2014DN10076A (en)
MY166560A (en) Ddr zeolite seed crystal, method for producing same, and method for producing ddr zeolite membrane
UA112540C2 (en) A FILM MEDICINAL FORM CONTAINING THE FREE SILDENAFIL BASE AND THE METHOD OF OBTAINING THIS
PH12014500996A1 (en) Precipitated silica sorbents
PH12016500299A1 (en) Selective hydrogen catalyst containing bimodal support and methods of making and using same
MY167230A (en) Water-dispersed pressure-sensitive adhesive composition and method for producing same
PH12015502003A1 (en) Ophthalmic formulations
WO2010004163A3 (en) Hydrogen-generating colloidal suspension
PL1860948T3 (en) Method of deparasitizing and parasiticidal powder
IN2013DE03637A (en)
EA033258B1 (en) Oral care composition