KR20130132931A - Gip 수용체 활성을 나타내는 글루카곤 유사체들 - Google Patents
Gip 수용체 활성을 나타내는 글루카곤 유사체들 Download PDFInfo
- Publication number
- KR20130132931A KR20130132931A KR1020137018994A KR20137018994A KR20130132931A KR 20130132931 A KR20130132931 A KR 20130132931A KR 1020137018994 A KR1020137018994 A KR 1020137018994A KR 20137018994 A KR20137018994 A KR 20137018994A KR 20130132931 A KR20130132931 A KR 20130132931A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- glucagon
- peptide
- seq
- optionally
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426285P | 2010-12-22 | 2010-12-22 | |
US61/426,285 | 2010-12-22 | ||
US201161514609P | 2011-08-03 | 2011-08-03 | |
US61/514,609 | 2011-08-03 | ||
PCT/US2011/066164 WO2012088116A2 (en) | 2010-12-22 | 2011-12-20 | Glucagon analogs exhibiting gip receptor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20130132931A true KR20130132931A (ko) | 2013-12-05 |
Family
ID=45476658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137018994A KR20130132931A (ko) | 2010-12-22 | 2011-12-20 | Gip 수용체 활성을 나타내는 글루카곤 유사체들 |
Country Status (21)
Country | Link |
---|---|
US (4) | US8507428B2 (ru) |
EP (1) | EP2654773B1 (ru) |
JP (1) | JP6086067B2 (ru) |
KR (1) | KR20130132931A (ru) |
CN (1) | CN103458920B (ru) |
AR (1) | AR084459A1 (ru) |
AU (1) | AU2011349331A1 (ru) |
BR (1) | BR112013015389A2 (ru) |
CA (1) | CA2821766A1 (ru) |
CL (1) | CL2013001783A1 (ru) |
CO (1) | CO6761302A2 (ru) |
CR (1) | CR20130295A (ru) |
EA (1) | EA201390941A1 (ru) |
EC (1) | ECSP13012697A (ru) |
ES (1) | ES2713952T3 (ru) |
MA (1) | MA34885B1 (ru) |
MX (1) | MX2013006304A (ru) |
NZ (1) | NZ612297A (ru) |
PE (1) | PE20140186A1 (ru) |
SG (1) | SG191194A1 (ru) |
WO (1) | WO2012088116A2 (ru) |
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EA019203B9 (ru) | 2008-06-17 | 2014-03-31 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Коагонисты глюкагонового рецептора/glp-1-рецептора |
CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
KR20120123443A (ko) * | 2010-01-27 | 2012-11-08 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 대사 장애 및 비만 치료용 글루카곤 길항제-gip 항진제 콘쥬게이트 |
ES2713952T3 (es) * | 2010-12-22 | 2019-05-24 | Univ Indiana Res & Tech Corp | Análogos de glucagón que muestran actividad de receptor de GIP |
JP2014501762A (ja) * | 2010-12-22 | 2014-01-23 | マルケイディア バイオテック, インコーポレイテッド | Gipおよびglp−1受容体活性グルカゴン系ペプチドにより代謝障害および肥満を治療するための方法 |
RS56173B1 (sr) | 2011-06-22 | 2017-11-30 | Univ Indiana Res & Tech Corp | Koagonisti receptora za glukagon/glp-1 receptora |
JP6352806B2 (ja) | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー/エス | 新規のグルカゴン類似体 |
EP2864351B1 (en) | 2012-06-21 | 2016-08-10 | Indiana University Research and Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
JP6525456B2 (ja) | 2012-11-20 | 2019-06-05 | メデリス ダイアビーティーズ,エルエルシー | インスリン抵抗性のための改善されたペプチド製剤 |
JP2016503771A (ja) | 2012-12-21 | 2016-02-08 | サノフイ | エキセンジン−4誘導体 |
US9714277B2 (en) * | 2013-03-14 | 2017-07-25 | Medimmune Limited | Pegylated glucagon and GLP-1 co-agonists for the treatment of obesity |
EP2986314A4 (en) * | 2013-03-15 | 2016-04-13 | Univ Indiana Res & Tech Corp | PROTOCOLS AND A PROLONGED ACTION |
US10450343B2 (en) | 2013-03-21 | 2019-10-22 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
WO2014161835A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof |
JP6594856B2 (ja) | 2013-04-18 | 2019-10-23 | ノヴォ ノルディスク アー/エス | 医療用の安定な遷延性glp−1/グルカゴン受容体コアゴニスト |
EP3010546B1 (en) * | 2013-06-20 | 2017-08-09 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
WO2015035419A1 (en) * | 2013-09-09 | 2015-03-12 | Hoffmann-La Roche Inc. | Dosages of gip/glp-1 co-agonist peptides for human administration |
US10286078B2 (en) | 2013-09-13 | 2019-05-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
WO2015086731A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
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TW201625670A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
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KR20230084337A (ko) | 2014-05-28 | 2023-06-12 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
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CR20130295A (es) | 2013-10-09 |
EP2654773B1 (en) | 2018-10-03 |
EP2654773A2 (en) | 2013-10-30 |
US20160115215A1 (en) | 2016-04-28 |
US9249206B2 (en) | 2016-02-02 |
US20120238493A1 (en) | 2012-09-20 |
EA201390941A1 (ru) | 2013-12-30 |
PE20140186A1 (es) | 2014-02-13 |
CA2821766A1 (en) | 2012-06-28 |
CN103458920B (zh) | 2016-07-06 |
CL2013001783A1 (es) | 2014-01-24 |
CO6761302A2 (es) | 2013-09-30 |
MA34885B1 (fr) | 2014-02-01 |
ES2713952T3 (es) | 2019-05-24 |
ECSP13012697A (es) | 2013-10-31 |
US20130116173A1 (en) | 2013-05-09 |
JP6086067B2 (ja) | 2017-03-01 |
US8507428B2 (en) | 2013-08-13 |
CN103458920A (zh) | 2013-12-18 |
NZ612297A (en) | 2015-10-30 |
US20150259393A1 (en) | 2015-09-17 |
US9587005B2 (en) | 2017-03-07 |
MX2013006304A (es) | 2013-07-02 |
WO2012088116A2 (en) | 2012-06-28 |
WO2012088116A3 (en) | 2012-11-15 |
SG191194A1 (en) | 2013-07-31 |
JP2014507402A (ja) | 2014-03-27 |
AU2011349331A1 (en) | 2013-07-11 |
BR112013015389A2 (pt) | 2016-11-22 |
AR084459A1 (es) | 2013-05-15 |
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