KR20120123534A - 치아의 기계적 내성을 향상시키는 방법 및 조성물 - Google Patents
치아의 기계적 내성을 향상시키는 방법 및 조성물 Download PDFInfo
- Publication number
- KR20120123534A KR20120123534A KR1020127023088A KR20127023088A KR20120123534A KR 20120123534 A KR20120123534 A KR 20120123534A KR 1020127023088 A KR1020127023088 A KR 1020127023088A KR 20127023088 A KR20127023088 A KR 20127023088A KR 20120123534 A KR20120123534 A KR 20120123534A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- phosphate
- hardness
- theobromine
- tooth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 238000000034 method Methods 0.000 title claims abstract description 69
- 208000002925 dental caries Diseases 0.000 claims abstract description 35
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims description 223
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 130
- 229960004559 theobromine Drugs 0.000 claims description 109
- 239000011775 sodium fluoride Substances 0.000 claims description 65
- 235000013024 sodium fluoride Nutrition 0.000 claims description 65
- 239000000606 toothpaste Substances 0.000 claims description 56
- 229940034610 toothpaste Drugs 0.000 claims description 49
- 238000011282 treatment Methods 0.000 claims description 42
- 238000007373 indentation Methods 0.000 claims description 31
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 26
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 239000011575 calcium Substances 0.000 claims description 23
- 239000001506 calcium phosphate Substances 0.000 claims description 21
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 20
- 229910052791 calcium Inorganic materials 0.000 claims description 18
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 18
- 235000011010 calcium phosphates Nutrition 0.000 claims description 18
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 18
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 18
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 17
- 229910019142 PO4 Inorganic materials 0.000 claims description 17
- 229960005069 calcium Drugs 0.000 claims description 17
- 239000010452 phosphate Substances 0.000 claims description 17
- -1 polymorphs Chemical compound 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 15
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 14
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- 150000005846 sugar alcohols Polymers 0.000 claims description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
- 239000002562 thickening agent Substances 0.000 claims description 12
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 12
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 11
- 239000003242 anti bacterial agent Substances 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
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- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 7
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
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- 239000000845 maltitol Substances 0.000 claims description 7
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- 229940035436 maltitol Drugs 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 229920000609 methyl cellulose Polymers 0.000 claims description 7
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- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 6
- 235000010216 calcium carbonate Nutrition 0.000 claims description 6
- 239000004227 calcium gluconate Substances 0.000 claims description 6
- 235000013927 calcium gluconate Nutrition 0.000 claims description 6
- 229960004494 calcium gluconate Drugs 0.000 claims description 6
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 6
- 239000010634 clove oil Substances 0.000 claims description 6
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
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- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 239000007951 isotonicity adjuster Substances 0.000 claims description 6
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- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 6
- 229960003451 lactitol Drugs 0.000 claims description 6
- 229960001855 mannitol Drugs 0.000 claims description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 6
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 6
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 6
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 6
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- 235000019798 tripotassium phosphate Nutrition 0.000 claims description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
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- 229910052698 phosphorus Inorganic materials 0.000 claims description 5
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- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims 4
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US30377410P | 2010-02-12 | 2010-02-12 | |
| US61/303,774 | 2010-02-12 | ||
| PCT/US2011/024734 WO2011100671A2 (en) | 2010-02-12 | 2011-02-14 | Methods and compositions to improve mechanical resistance of teeth |
Publications (1)
| Publication Number | Publication Date |
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| KR20120123534A true KR20120123534A (ko) | 2012-11-08 |
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| KR1020127023088A Withdrawn KR20120123534A (ko) | 2010-02-12 | 2011-02-14 | 치아의 기계적 내성을 향상시키는 방법 및 조성물 |
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| EP (1) | EP2533786B1 (enExample) |
| JP (1) | JP6114036B2 (enExample) |
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| CN (2) | CN102821768A (enExample) |
| AU (1) | AU2011215617B2 (enExample) |
| BR (1) | BR112012019844A2 (enExample) |
| CA (1) | CA2789595C (enExample) |
| ES (1) | ES2617758T3 (enExample) |
| IL (1) | IL221403A0 (enExample) |
| MX (1) | MX2012009313A (enExample) |
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| RU (1) | RU2591084C2 (enExample) |
| SG (2) | SG183277A1 (enExample) |
| WO (1) | WO2011100671A2 (enExample) |
| ZA (1) | ZA201206742B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150111661A (ko) * | 2014-03-26 | 2015-10-06 | 주식회사 엘지생활건강 | 치면 부착용 겔 조성물 및 이를 포함하는 키트 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2007214265B2 (en) | 2006-02-09 | 2012-06-14 | The University Of Melbourne | Fluoride composition and methods for dental mineralization |
| CN102821768A (zh) | 2010-02-12 | 2012-12-12 | 斯欧考普控股公司 | 提高牙齿的机械抗性的方法和组合物 |
| HK1207992A1 (en) * | 2012-06-20 | 2016-02-19 | 斯欧考普控股公司 | Compositions containing theobromine and their use in treating tooth hypersensitivity |
| US9937184B2 (en) * | 2013-03-15 | 2018-04-10 | Theocorp Holding Company, Llc | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
| PL3024428T3 (pl) | 2013-07-23 | 2021-07-05 | The University Of Melbourne | Kompozycje i sposoby mineralizacji zębów |
| FR3011466A1 (fr) * | 2013-10-09 | 2015-04-10 | Roquette Freres | Utilisation d'un polyol dans la remineralisation de l'email |
| RU2716134C2 (ru) | 2013-12-24 | 2020-03-06 | Де Юниверсити Оф Мельбурн | Стабилизированные композиции на основе олова (II) |
| RU2720242C2 (ru) * | 2014-12-24 | 2020-04-28 | Юниверсити Оф Мельбурн | Минерализующие фторсодержащие композиции |
| KR102862249B1 (ko) | 2017-03-14 | 2025-09-19 | 더 유니버시티 오브 멜버른 | 치은염을 위한 치료 |
| EA201991935A1 (ru) | 2017-03-14 | 2020-02-14 | Де Юниверсити Оф Мельбурн | Комплексы для лечения чувствительности |
| CA3133097A1 (en) | 2019-03-13 | 2020-09-17 | The University Of Melbourne | Compositions and methods for promoting mineralization |
| CN110917210B (zh) * | 2019-12-27 | 2022-04-19 | 安徽医科大学 | 一种牙齿矿化漂白双功能糊剂、制备方法及应用 |
| CN112094699B (zh) * | 2020-09-27 | 2023-03-28 | 广西壮族自治区林业科学研究院 | 一种樟树纯露的提取方法 |
| DE102021111354A1 (de) * | 2021-05-03 | 2022-11-03 | Dr. Kurt Wolff Gmbh & Co. Kg | Mundpflegemittel |
| DE102021111387A1 (de) | 2021-05-03 | 2022-11-03 | Dr. Kurt Wolff Gmbh & Co. Kg | Oralgel-Zusammensetzung und ihre Verwendung |
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| DE4007431A1 (de) * | 1990-03-09 | 1991-09-12 | Henkel Kgaa | Den zahnschmelz schuetzende mund- und zahnpflegemittel |
| US5626838A (en) * | 1995-03-13 | 1997-05-06 | The Procter & Gamble Company | Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx |
| US5571502A (en) * | 1995-08-08 | 1996-11-05 | Enamelon Research | Stable single-part compositions and the use thereof for remineralization of lesions in teeth |
| US6183711B1 (en) * | 1995-12-27 | 2001-02-06 | Tetsuo Nakamoto | Apatite-forming-systems: methods and products |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| JP3719874B2 (ja) * | 1998-04-24 | 2005-11-24 | サンスター株式会社 | 口腔用組成物 |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| KR20030032484A (ko) * | 2001-10-18 | 2003-04-26 | 롯데제과주식회사 | 발암 억제효능을 갖는 데오브로민 |
| AU2003241807A1 (en) * | 2002-05-27 | 2003-12-12 | Morinaga And Co., Ltd. | Composition against periodontal bacteria and foods, drinks and mouth washers against periodontal bacteria containing the composition |
| US20050152852A1 (en) * | 2002-05-27 | 2005-07-14 | Morinaga & Co., Ltd. | Use of antibacterial component extracted from cacao mass for inhibiting the growth of periodontal bacteria |
| US6953817B2 (en) * | 2002-08-05 | 2005-10-11 | Colgate-Palmolive Company | Dual component dentinal desensitizing dentifrice |
| US20040034042A1 (en) * | 2002-08-14 | 2004-02-19 | Masao Tsuji | Preservative composition |
| EP1604671A4 (en) * | 2003-02-26 | 2006-03-29 | Kyowa Hakko Kogyo Kk | MUSCLE TREATMENT AND MEANS FOR PREVENTING OR TREATING MUSCLE WEAKNESS |
| DE102004041496A1 (de) | 2004-08-27 | 2006-03-02 | Symrise Gmbh & Co. Kg | Hydroxybenzoesäureamide und deren Verwendung zur Maskierung von bitterem Geschmack |
| JP4820320B2 (ja) * | 2006-03-28 | 2011-11-24 | 花王株式会社 | 口腔用組成物 |
| JP5633998B2 (ja) * | 2006-09-27 | 2014-12-03 | 三栄源エフ・エフ・アイ株式会社 | 歯の再石灰化促進剤およびこれを含む口腔または経口用組成物 |
| JP5354865B2 (ja) * | 2007-03-30 | 2013-11-27 | 太陽化学株式会社 | リン酸カルシウム溶解抑制剤 |
| JP5553396B2 (ja) * | 2007-04-10 | 2014-07-16 | 株式会社サンギ | 再石灰化促進剤及び口腔用組成物 |
| AU2008308951B2 (en) * | 2007-10-01 | 2012-07-26 | Colgate-Palmolive Company | Oral compositions containing botanical extracts |
| JP5196127B2 (ja) * | 2007-12-19 | 2013-05-15 | ライオン株式会社 | 口腔用組成物 |
| JP5656368B2 (ja) | 2009-05-29 | 2015-01-21 | 花王株式会社 | 歯磨剤 |
| CN102821768A (zh) | 2010-02-12 | 2012-12-12 | 斯欧考普控股公司 | 提高牙齿的机械抗性的方法和组合物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150111661A (ko) * | 2014-03-26 | 2015-10-06 | 주식회사 엘지생활건강 | 치면 부착용 겔 조성물 및 이를 포함하는 키트 |
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| US20130129641A1 (en) | 2013-05-23 |
| AU2011215617A1 (en) | 2012-09-13 |
| WO2011100671A3 (en) | 2011-12-22 |
| MX2012009313A (es) | 2012-11-06 |
| IL221403A0 (en) | 2012-10-31 |
| WO2011100671A2 (en) | 2011-08-18 |
| SG183277A1 (en) | 2012-09-27 |
| CN102821768A (zh) | 2012-12-12 |
| JP2013519688A (ja) | 2013-05-30 |
| ES2617758T3 (es) | 2017-06-19 |
| CA2789595C (en) | 2017-11-28 |
| CA2789595A1 (en) | 2011-08-18 |
| NZ601989A (en) | 2014-11-28 |
| RU2591084C2 (ru) | 2016-07-10 |
| JP6114036B2 (ja) | 2017-04-12 |
| EP2533786A4 (en) | 2013-06-12 |
| AU2011215617B2 (en) | 2016-01-28 |
| CN106668064A (zh) | 2017-05-17 |
| SG10201500795WA (en) | 2015-04-29 |
| RU2012133316A (ru) | 2014-03-20 |
| EP2533786B1 (en) | 2016-12-28 |
| BR112012019844A2 (pt) | 2017-12-05 |
| ZA201206742B (en) | 2013-05-29 |
| EP2533786A2 (en) | 2012-12-19 |
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