RU2591084C2 - Способы и композиции для улучшения механической прочности зубов - Google Patents
Способы и композиции для улучшения механической прочности зубов Download PDFInfo
- Publication number
- RU2591084C2 RU2591084C2 RU2012133316/15A RU2012133316A RU2591084C2 RU 2591084 C2 RU2591084 C2 RU 2591084C2 RU 2012133316/15 A RU2012133316/15 A RU 2012133316/15A RU 2012133316 A RU2012133316 A RU 2012133316A RU 2591084 C2 RU2591084 C2 RU 2591084C2
- Authority
- RU
- Russia
- Prior art keywords
- phosphate
- composition
- theobromine
- combinations
- calcium
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 101
- 238000000034 method Methods 0.000 title claims abstract description 62
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims abstract description 232
- 229960004559 theobromine Drugs 0.000 claims abstract description 113
- 208000002925 dental caries Diseases 0.000 claims abstract description 31
- 239000011575 calcium Substances 0.000 claims abstract description 24
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 21
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 17
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 17
- 239000010452 phosphate Substances 0.000 claims abstract description 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 17
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 15
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 15
- 230000001965 increasing effect Effects 0.000 claims abstract description 13
- 241000124008 Mammalia Species 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 229960005069 calcium Drugs 0.000 claims description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- 238000007373 indentation Methods 0.000 claims description 13
- 150000005846 sugar alcohols Polymers 0.000 claims description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
- 239000003242 anti bacterial agent Substances 0.000 claims description 12
- 239000007951 isotonicity adjuster Substances 0.000 claims description 12
- 239000002562 thickening agent Substances 0.000 claims description 12
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 12
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 235000010356 sorbitol Nutrition 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 8
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001110 calcium chloride Substances 0.000 claims description 8
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 8
- 235000011148 calcium chloride Nutrition 0.000 claims description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 8
- 239000000811 xylitol Substances 0.000 claims description 8
- 235000010447 xylitol Nutrition 0.000 claims description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
- 229960002675 xylitol Drugs 0.000 claims description 8
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
- 239000004386 Erythritol Substances 0.000 claims description 7
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 7
- 235000019414 erythritol Nutrition 0.000 claims description 7
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 7
- 229940009714 erythritol Drugs 0.000 claims description 7
- 239000000905 isomalt Substances 0.000 claims description 7
- 235000010439 isomalt Nutrition 0.000 claims description 7
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 7
- 239000000845 maltitol Substances 0.000 claims description 7
- 235000010449 maltitol Nutrition 0.000 claims description 7
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 7
- 229940035436 maltitol Drugs 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 229960001855 mannitol Drugs 0.000 claims description 7
- 229920000609 methyl cellulose Polymers 0.000 claims description 7
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 235000010981 methylcellulose Nutrition 0.000 claims description 7
- 239000001923 methylcellulose Substances 0.000 claims description 7
- 229960003500 triclosan Drugs 0.000 claims description 7
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 6
- 235000010216 calcium carbonate Nutrition 0.000 claims description 6
- 239000004227 calcium gluconate Substances 0.000 claims description 6
- 235000013927 calcium gluconate Nutrition 0.000 claims description 6
- 229960004494 calcium gluconate Drugs 0.000 claims description 6
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 6
- 239000010634 clove oil Substances 0.000 claims description 6
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 6
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 6
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 239000000832 lactitol Substances 0.000 claims description 6
- 235000010448 lactitol Nutrition 0.000 claims description 6
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 6
- 229960003451 lactitol Drugs 0.000 claims description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 6
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 6
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 6
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 6
- 239000001488 sodium phosphate Substances 0.000 claims description 6
- 229960002920 sorbitol Drugs 0.000 claims description 6
- 229910000404 tripotassium phosphate Inorganic materials 0.000 claims description 6
- 235000019798 tripotassium phosphate Nutrition 0.000 claims description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 6
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 3
- 235000019800 disodium phosphate Nutrition 0.000 claims 3
- 230000000395 remineralizing effect Effects 0.000 claims 1
- 210000003298 dental enamel Anatomy 0.000 abstract description 31
- 230000000694 effects Effects 0.000 abstract description 16
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- 238000001953 recrystallisation Methods 0.000 abstract description 3
- 239000011253 protective coating Substances 0.000 abstract description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 106
- 239000011775 sodium fluoride Substances 0.000 description 53
- 235000013024 sodium fluoride Nutrition 0.000 description 53
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- 239000000551 dentifrice Substances 0.000 description 23
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 20
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 20
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| US30377410P | 2010-02-12 | 2010-02-12 | |
| US61/303,774 | 2010-02-12 | ||
| PCT/US2011/024734 WO2011100671A2 (en) | 2010-02-12 | 2011-02-14 | Methods and compositions to improve mechanical resistance of teeth |
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| RU2012133316A RU2012133316A (ru) | 2014-03-20 |
| RU2591084C2 true RU2591084C2 (ru) | 2016-07-10 |
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| RU2012133316/15A RU2591084C2 (ru) | 2010-02-12 | 2011-02-14 | Способы и композиции для улучшения механической прочности зубов |
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| AU (1) | AU2011215617B2 (enExample) |
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| ZA (1) | ZA201206742B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007214265B2 (en) | 2006-02-09 | 2012-06-14 | The University Of Melbourne | Fluoride composition and methods for dental mineralization |
| CN102821768A (zh) | 2010-02-12 | 2012-12-12 | 斯欧考普控股公司 | 提高牙齿的机械抗性的方法和组合物 |
| HK1207992A1 (en) * | 2012-06-20 | 2016-02-19 | 斯欧考普控股公司 | Compositions containing theobromine and their use in treating tooth hypersensitivity |
| US9937184B2 (en) * | 2013-03-15 | 2018-04-10 | Theocorp Holding Company, Llc | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
| PL3024428T3 (pl) | 2013-07-23 | 2021-07-05 | The University Of Melbourne | Kompozycje i sposoby mineralizacji zębów |
| FR3011466A1 (fr) * | 2013-10-09 | 2015-04-10 | Roquette Freres | Utilisation d'un polyol dans la remineralisation de l'email |
| RU2716134C2 (ru) | 2013-12-24 | 2020-03-06 | Де Юниверсити Оф Мельбурн | Стабилизированные композиции на основе олова (II) |
| KR102187824B1 (ko) * | 2014-03-26 | 2020-12-07 | 주식회사 엘지생활건강 | 치면 부착용 겔 조성물 및 이를 포함하는 키트 |
| RU2720242C2 (ru) * | 2014-12-24 | 2020-04-28 | Юниверсити Оф Мельбурн | Минерализующие фторсодержащие композиции |
| KR102862249B1 (ko) | 2017-03-14 | 2025-09-19 | 더 유니버시티 오브 멜버른 | 치은염을 위한 치료 |
| EA201991935A1 (ru) | 2017-03-14 | 2020-02-14 | Де Юниверсити Оф Мельбурн | Комплексы для лечения чувствительности |
| CA3133097A1 (en) | 2019-03-13 | 2020-09-17 | The University Of Melbourne | Compositions and methods for promoting mineralization |
| CN110917210B (zh) * | 2019-12-27 | 2022-04-19 | 安徽医科大学 | 一种牙齿矿化漂白双功能糊剂、制备方法及应用 |
| CN112094699B (zh) * | 2020-09-27 | 2023-03-28 | 广西壮族自治区林业科学研究院 | 一种樟树纯露的提取方法 |
| DE102021111354A1 (de) * | 2021-05-03 | 2022-11-03 | Dr. Kurt Wolff Gmbh & Co. Kg | Mundpflegemittel |
| DE102021111387A1 (de) | 2021-05-03 | 2022-11-03 | Dr. Kurt Wolff Gmbh & Co. Kg | Oralgel-Zusammensetzung und ihre Verwendung |
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| US6183711B1 (en) * | 1995-12-27 | 2001-02-06 | Tetsuo Nakamoto | Apatite-forming-systems: methods and products |
| US20040034042A1 (en) * | 2002-08-14 | 2004-02-19 | Masao Tsuji | Preservative composition |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US20050152852A1 (en) * | 2002-05-27 | 2005-07-14 | Morinaga & Co., Ltd. | Use of antibacterial component extracted from cacao mass for inhibiting the growth of periodontal bacteria |
| RU2311899C2 (ru) * | 2002-12-13 | 2007-12-10 | Дзе Проктер Энд Гамбл Компани | Способ улучшения фторирования и минерализации зубов |
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| DE4007431A1 (de) * | 1990-03-09 | 1991-09-12 | Henkel Kgaa | Den zahnschmelz schuetzende mund- und zahnpflegemittel |
| US5626838A (en) * | 1995-03-13 | 1997-05-06 | The Procter & Gamble Company | Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx |
| US5571502A (en) * | 1995-08-08 | 1996-11-05 | Enamelon Research | Stable single-part compositions and the use thereof for remineralization of lesions in teeth |
| JP3719874B2 (ja) * | 1998-04-24 | 2005-11-24 | サンスター株式会社 | 口腔用組成物 |
| KR20030032484A (ko) * | 2001-10-18 | 2003-04-26 | 롯데제과주식회사 | 발암 억제효능을 갖는 데오브로민 |
| AU2003241807A1 (en) * | 2002-05-27 | 2003-12-12 | Morinaga And Co., Ltd. | Composition against periodontal bacteria and foods, drinks and mouth washers against periodontal bacteria containing the composition |
| US6953817B2 (en) * | 2002-08-05 | 2005-10-11 | Colgate-Palmolive Company | Dual component dentinal desensitizing dentifrice |
| EP1604671A4 (en) * | 2003-02-26 | 2006-03-29 | Kyowa Hakko Kogyo Kk | MUSCLE TREATMENT AND MEANS FOR PREVENTING OR TREATING MUSCLE WEAKNESS |
| DE102004041496A1 (de) | 2004-08-27 | 2006-03-02 | Symrise Gmbh & Co. Kg | Hydroxybenzoesäureamide und deren Verwendung zur Maskierung von bitterem Geschmack |
| JP4820320B2 (ja) * | 2006-03-28 | 2011-11-24 | 花王株式会社 | 口腔用組成物 |
| JP5633998B2 (ja) * | 2006-09-27 | 2014-12-03 | 三栄源エフ・エフ・アイ株式会社 | 歯の再石灰化促進剤およびこれを含む口腔または経口用組成物 |
| JP5354865B2 (ja) * | 2007-03-30 | 2013-11-27 | 太陽化学株式会社 | リン酸カルシウム溶解抑制剤 |
| JP5553396B2 (ja) * | 2007-04-10 | 2014-07-16 | 株式会社サンギ | 再石灰化促進剤及び口腔用組成物 |
| AU2008308951B2 (en) * | 2007-10-01 | 2012-07-26 | Colgate-Palmolive Company | Oral compositions containing botanical extracts |
| JP5196127B2 (ja) * | 2007-12-19 | 2013-05-15 | ライオン株式会社 | 口腔用組成物 |
| JP5656368B2 (ja) | 2009-05-29 | 2015-01-21 | 花王株式会社 | 歯磨剤 |
| CN102821768A (zh) | 2010-02-12 | 2012-12-12 | 斯欧考普控股公司 | 提高牙齿的机械抗性的方法和组合物 |
-
2011
- 2011-02-14 CN CN2011800104594A patent/CN102821768A/zh active Pending
- 2011-02-14 RU RU2012133316/15A patent/RU2591084C2/ru not_active Application Discontinuation
- 2011-02-14 AU AU2011215617A patent/AU2011215617B2/en not_active Ceased
- 2011-02-14 CA CA2789595A patent/CA2789595C/en active Active
- 2011-02-14 BR BR112012019844A patent/BR112012019844A2/pt not_active IP Right Cessation
- 2011-02-14 CN CN201710170152.XA patent/CN106668064A/zh active Pending
- 2011-02-14 WO PCT/US2011/024734 patent/WO2011100671A2/en not_active Ceased
- 2011-02-14 MX MX2012009313A patent/MX2012009313A/es active IP Right Grant
- 2011-02-14 US US13/642,125 patent/US9610235B2/en active Active
- 2011-02-14 EP EP11742948.0A patent/EP2533786B1/en active Active
- 2011-02-14 JP JP2012553073A patent/JP6114036B2/ja active Active
- 2011-02-14 ES ES11742948.0T patent/ES2617758T3/es active Active
- 2011-02-14 KR KR1020127023088A patent/KR20120123534A/ko not_active Withdrawn
- 2011-02-14 SG SG2012059564A patent/SG183277A1/en unknown
- 2011-02-14 SG SG10201500795WA patent/SG10201500795WA/en unknown
- 2011-02-14 NZ NZ601989A patent/NZ601989A/en not_active IP Right Cessation
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2012
- 2012-08-09 IL IL221403A patent/IL221403A0/en unknown
- 2012-09-10 ZA ZA2012/06742A patent/ZA201206742B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183711B1 (en) * | 1995-12-27 | 2001-02-06 | Tetsuo Nakamoto | Apatite-forming-systems: methods and products |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US20050152852A1 (en) * | 2002-05-27 | 2005-07-14 | Morinaga & Co., Ltd. | Use of antibacterial component extracted from cacao mass for inhibiting the growth of periodontal bacteria |
| US20040034042A1 (en) * | 2002-08-14 | 2004-02-19 | Masao Tsuji | Preservative composition |
| RU2311899C2 (ru) * | 2002-12-13 | 2007-12-10 | Дзе Проктер Энд Гамбл Компани | Способ улучшения фторирования и минерализации зубов |
Also Published As
| Publication number | Publication date |
|---|---|
| US9610235B2 (en) | 2017-04-04 |
| US20130129641A1 (en) | 2013-05-23 |
| AU2011215617A1 (en) | 2012-09-13 |
| WO2011100671A3 (en) | 2011-12-22 |
| MX2012009313A (es) | 2012-11-06 |
| IL221403A0 (en) | 2012-10-31 |
| WO2011100671A2 (en) | 2011-08-18 |
| SG183277A1 (en) | 2012-09-27 |
| KR20120123534A (ko) | 2012-11-08 |
| CN102821768A (zh) | 2012-12-12 |
| JP2013519688A (ja) | 2013-05-30 |
| ES2617758T3 (es) | 2017-06-19 |
| CA2789595C (en) | 2017-11-28 |
| CA2789595A1 (en) | 2011-08-18 |
| NZ601989A (en) | 2014-11-28 |
| JP6114036B2 (ja) | 2017-04-12 |
| EP2533786A4 (en) | 2013-06-12 |
| AU2011215617B2 (en) | 2016-01-28 |
| CN106668064A (zh) | 2017-05-17 |
| SG10201500795WA (en) | 2015-04-29 |
| RU2012133316A (ru) | 2014-03-20 |
| EP2533786B1 (en) | 2016-12-28 |
| BR112012019844A2 (pt) | 2017-12-05 |
| ZA201206742B (en) | 2013-05-29 |
| EP2533786A2 (en) | 2012-12-19 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20160112 |