KR20120093002A - Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 - Google Patents

Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 Download PDF

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KR20120093002A
KR20120093002A KR1020110012983A KR20110012983A KR20120093002A KR 20120093002 A KR20120093002 A KR 20120093002A KR 1020110012983 A KR1020110012983 A KR 1020110012983A KR 20110012983 A KR20110012983 A KR 20110012983A KR 20120093002 A KR20120093002 A KR 20120093002A
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South Korea
Prior art keywords
interleukin
cells
amino acid
tail region
acid residues
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Pending
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KR1020110012983A
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English (en)
Korean (ko)
Inventor
이재면
윤주천
박상우
김종선
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(주)에이티젠
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Priority to KR1020110012983A priority Critical patent/KR20120093002A/ko
Priority to AU2012219184A priority patent/AU2012219184A1/en
Priority to EA201391187A priority patent/EA038959B1/ru
Priority to CA2826053A priority patent/CA2826053C/en
Priority to MX2013009380A priority patent/MX361731B/es
Priority to PCT/IB2012/000259 priority patent/WO2012110878A2/en
Priority to ES12747246T priority patent/ES2797549T3/es
Priority to SG2013058375A priority patent/SG192247A1/en
Priority to NZ710432A priority patent/NZ710432B2/en
Priority to US13/985,301 priority patent/US11442069B2/en
Priority to MYPI2013002917A priority patent/MY175351A/en
Priority to KR1020137031527A priority patent/KR101438573B1/ko
Priority to JP2013553044A priority patent/JP6629497B2/ja
Priority to DK12747246.2T priority patent/DK2676139T3/da
Priority to UAA201310947A priority patent/UA120697C2/uk
Priority to RU2013141487A priority patent/RU2635194C2/ru
Priority to EP12747246.2A priority patent/EP2676139B1/en
Priority to BR112013020454-0A priority patent/BR112013020454B1/pt
Priority to CN201280008685.3A priority patent/CN103370622B/zh
Priority to NZ614345A priority patent/NZ614345B2/en
Priority to KR1020137006311A priority patent/KR101341538B1/ko
Priority to TW101104742A priority patent/TWI668445B/zh
Priority to TW106103526A priority patent/TWI681191B/zh
Publication of KR20120093002A publication Critical patent/KR20120093002A/ko
Priority to CL2013002361A priority patent/CL2013002361A1/es
Priority to IL227952A priority patent/IL227952B/en
Priority to JP2017069908A priority patent/JP6798922B2/ja
Priority to AU2017202628A priority patent/AU2017202628B2/en
Priority to JP2019126244A priority patent/JP2019207242A/ja
Priority to JP2021197948A priority patent/JP2022043119A/ja
Priority to US17/691,391 priority patent/US12379384B2/en
Priority to JP2023076634A priority patent/JP7660605B2/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866—Interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020110012983A 2011-02-14 2011-02-14 Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 Pending KR20120093002A (ko)

Priority Applications (31)

Application Number Priority Date Filing Date Title
KR1020110012983A KR20120093002A (ko) 2011-02-14 2011-02-14 Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트
EP12747246.2A EP2676139B1 (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of nk cell activity
RU2013141487A RU2635194C2 (ru) 2011-02-14 2012-02-10 Способ диагностики злокачественной опухоли и набор для диагностики путем измерения активности nk-клеток
CA2826053A CA2826053C (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of nk cell activity
MX2013009380A MX361731B (es) 2011-02-14 2012-02-10 Método para diagnosticar cáncer y kit de diagnóstico usando medición de actividad de células nk.
PCT/IB2012/000259 WO2012110878A2 (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of nk cell activity
ES12747246T ES2797549T3 (es) 2011-02-14 2012-02-10 Procedimiento para diagnosticar cáncer y kit de diagnóstico a través de la medición de actividad de células NK
SG2013058375A SG192247A1 (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of nk cell activity
NZ710432A NZ710432B2 (en) 2011-02-14 2012-02-10 Method and use for measurement of nk cell activity
BR112013020454-0A BR112013020454B1 (pt) 2011-02-14 2012-02-10 Método para medir a atividade de células assassinas naturais nk, proteína de fusão, composição para ativar células nk, kit para medir a atividade de célula nk
MYPI2013002917A MY175351A (en) 2011-02-14 2012-02-10 Method and kit for measurement of nk cell activity
KR1020137031527A KR101438573B1 (ko) 2011-02-14 2012-02-10 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트
JP2013553044A JP6629497B2 (ja) 2011-02-14 2012-02-10 がんを診断する方法およびｎｋ細胞活性の測定を使用した診断キット
DK12747246.2T DK2676139T3 (da) 2011-02-14 2012-02-10 Fremgangsmåde til diagnosticering af cancer og diagnosekit til måling af nk celle-aktivitet
UAA201310947A UA120697C2 (uk) 2011-02-14 2012-02-10 Спосіб виміру активності природних клітин-кілерів (nk) у зразку цільної крові
AU2012219184A AU2012219184A1 (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of NK cell activity
CN201280008685.3A CN103370622B (zh) 2011-02-14 2012-02-10 用于测量nk细胞活性的方法和试剂盒
US13/985,301 US11442069B2 (en) 2011-02-14 2012-02-10 Method of diagnosing cancer and diagnosis kit using measurement of NK cell activity
EA201391187A EA038959B1 (ru) 2011-02-14 2012-02-10 Способ диагностики злокачественной опухоли и набор для диагностики путем измерения активности nk-клеток
NZ614345A NZ614345B2 (en) 2011-02-14 2012-02-10 Method and use for measurement of nk cell activity
KR1020137006311A KR101341538B1 (ko) 2011-02-14 2012-02-10 전혈 시료를 이용한 nk 세포의 활성 측정 방법 및 측정 키트
TW101104742A TWI668445B (zh) 2011-02-14 2012-02-14 測量天然殺手細胞活性之方法和診斷套組
TW106103526A TWI681191B (zh) 2011-02-14 2012-02-14 測量天然殺手細胞活性之方法和診斷套組
CL2013002361A CL2013002361A1 (es) 2011-02-14 2013-08-14 Metodo para medir actividad de células natural killer (nk); kit para medir dicha actividad; proteína de fusión; composicion para activar células nk; polipéptido, oligonucleótido, vector y célula hospedera que comprenden la proteína;
IL227952A IL227952B (en) 2011-02-14 2013-08-14 Method of diagnosing cancer and diagnosis kit using measurement of nk activity
JP2017069908A JP6798922B2 (ja) 2011-02-14 2017-03-31 がんを診断する方法およびｎｋ細胞活性の測定を使用した診断キット
AU2017202628A AU2017202628B2 (en) 2011-02-14 2017-04-20 Method of diagnosing cancer and diagnosis kit using measurement of NK cell activity
JP2019126244A JP2019207242A (ja) 2011-02-14 2019-07-05 がんを診断する方法およびｎｋ細胞活性の測定を使用した診断キット
JP2021197948A JP2022043119A (ja) 2011-02-14 2021-12-06 がんを診断する方法およびｎｋ細胞活性の測定を使用した診断キット
US17/691,391 US12379384B2 (en) 2011-02-14 2022-03-10 Method of diagnosing cancer and diagnosis kit using measurement of NK cell activity
JP2023076634A JP7660605B2 (ja) 2011-02-14 2023-05-08 がんを診断する方法およびｎｋ細胞活性の測定を使用した診断キット

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110012983A KR20120093002A (ko) 2011-02-14 2011-02-14 Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트

Publications (1)

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KR20120093002A true KR20120093002A (ko) 2012-08-22

Family

ID=46672988

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020110012983A Pending KR20120093002A (ko) 2011-02-14 2011-02-14 Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트
KR1020137006311A Active KR101341538B1 (ko) 2011-02-14 2012-02-10 전혈 시료를 이용한 nk 세포의 활성 측정 방법 및 측정 키트
KR1020137031527A Active KR101438573B1 (ko) 2011-02-14 2012-02-10 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020137006311A Active KR101341538B1 (ko) 2011-02-14 2012-02-10 전혈 시료를 이용한 nk 세포의 활성 측정 방법 및 측정 키트
KR1020137031527A Active KR101438573B1 (ko) 2011-02-14 2012-02-10 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트

Country Status (20)

Country Link
US (2) US11442069B2 (cg-RX-API-DMAC7.html)
EP (1) EP2676139B1 (cg-RX-API-DMAC7.html)
JP (5) JP6629497B2 (cg-RX-API-DMAC7.html)
KR (3) KR20120093002A (cg-RX-API-DMAC7.html)
CN (1) CN103370622B (cg-RX-API-DMAC7.html)
AU (2) AU2012219184A1 (cg-RX-API-DMAC7.html)
BR (1) BR112013020454B1 (cg-RX-API-DMAC7.html)
CA (1) CA2826053C (cg-RX-API-DMAC7.html)
CL (1) CL2013002361A1 (cg-RX-API-DMAC7.html)
DK (1) DK2676139T3 (cg-RX-API-DMAC7.html)
EA (1) EA038959B1 (cg-RX-API-DMAC7.html)
ES (1) ES2797549T3 (cg-RX-API-DMAC7.html)
IL (1) IL227952B (cg-RX-API-DMAC7.html)
MX (1) MX361731B (cg-RX-API-DMAC7.html)
MY (1) MY175351A (cg-RX-API-DMAC7.html)
RU (1) RU2635194C2 (cg-RX-API-DMAC7.html)
SG (1) SG192247A1 (cg-RX-API-DMAC7.html)
TW (2) TWI681191B (cg-RX-API-DMAC7.html)
UA (1) UA120697C2 (cg-RX-API-DMAC7.html)
WO (1) WO2012110878A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101438573B1 (ko) * 2011-02-14 2014-09-12 (주)에이티젠 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6549570B2 (ja) 2013-11-05 2019-07-24 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 膀胱癌バイオマーカー
JP6073417B2 (ja) * 2015-06-26 2017-02-01 チャ バイオテック カンパニー リミテッド 自然殺害細胞増殖方法、及び自然殺害細胞増殖用の組成物
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
WO2017204446A2 (ko) * 2016-05-24 2017-11-30 울산대학교 산학협력단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
CN106085958A (zh) * 2016-08-04 2016-11-09 英普乐孚生物技术(上海)有限公司 一种nk细胞的制备方法
CN106222140A (zh) * 2016-08-04 2016-12-14 英普乐孚生物技术(上海)有限公司 一种nk细胞无血清培养基及其配制方法
CN107686828A (zh) * 2016-08-04 2018-02-13 英普乐孚生物技术(上海)有限公司 一种nk细胞无血清培养基
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