KR20120066067A - 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 - Google Patents

5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 Download PDF

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Publication number
KR20120066067A
KR20120066067A KR1020127011980A KR20127011980A KR20120066067A KR 20120066067 A KR20120066067 A KR 20120066067A KR 1020127011980 A KR1020127011980 A KR 1020127011980A KR 20127011980 A KR20127011980 A KR 20127011980A KR 20120066067 A KR20120066067 A KR 20120066067A
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KR
South Korea
Prior art keywords
lower alkyl
formula
phenyl
methyl
synthesis
Prior art date
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Ceased
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KR1020127011980A
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English (en)
Korean (ko)
Inventor
조셉 맥케나
웬-충 시에
Original Assignee
노파르티스 아게
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Publication of KR20120066067A publication Critical patent/KR20120066067A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
KR1020127011980A 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법 Ceased KR20120066067A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68897705P 2005-06-09 2005-06-09
US60/688,977 2005-06-09
US70559005P 2005-08-04 2005-08-04
US60/705,590 2005-08-04

Related Parent Applications (1)

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KR1020077028638A Division KR101216249B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020137025659A Division KR101514593B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법

Publications (1)

Publication Number Publication Date
KR20120066067A true KR20120066067A (ko) 2012-06-21

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020127011980A Ceased KR20120066067A (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법
KR1020077028638A Active KR101216249B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법
KR1020137025659A Active KR101514593B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020077028638A Active KR101216249B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법
KR1020137025659A Active KR101514593B1 (ko) 2005-06-09 2006-06-07 5-(메틸-1ｈ-이미다졸-1-일)-3-(트리플루오로메틸)-벤젠아민의 합성 방법

Country Status (31)

Country Link
US (2) US8124763B2 (enExample)
EP (1) EP1924574B1 (enExample)
JP (1) JP5118024B2 (enExample)
KR (3) KR20120066067A (enExample)
AR (1) AR053890A1 (enExample)
AT (1) ATE487709T1 (enExample)
AU (1) AU2006258051B2 (enExample)
BR (1) BRPI0611663A2 (enExample)
CA (1) CA2610105C (enExample)
CY (1) CY1111428T1 (enExample)
DE (1) DE602006018156D1 (enExample)
DK (1) DK1924574T3 (enExample)
EC (1) ECSP077982A (enExample)
EG (1) EG25039A (enExample)
GT (1) GT200600217A (enExample)
IL (1) IL187421A (enExample)
JO (1) JO2636B1 (enExample)
MA (1) MA29599B1 (enExample)
MX (1) MX2007015423A (enExample)
MY (1) MY147436A (enExample)
NO (1) NO340743B1 (enExample)
NZ (1) NZ563740A (enExample)
PE (1) PE20070015A1 (enExample)
PL (1) PL1924574T3 (enExample)
PT (1) PT1924574E (enExample)
RU (1) RU2444520C2 (enExample)
SA (1) SA06270147B1 (enExample)
SI (1) SI1924574T1 (enExample)
TN (1) TNSN07463A1 (enExample)
TW (1) TWI430999B (enExample)
WO (1) WO2006135641A2 (enExample)

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WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
EP2530081A3 (en) 2008-11-05 2013-04-10 Teva Pharmaceutical Industries, Ltd. Nilotinib HCI crystalline forms
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
MX2013010977A (es) 2011-03-31 2013-10-30 Procter & Gamble Sistema, modelos y metodos para identificar y evaluar agentes dermoactivos eficaces para tratar la caspa/dermatitis seborreica.
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
GB2514285B (en) 2012-02-13 2018-07-18 Grindeks Jsc Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
EP2859486A2 (en) 2012-06-06 2015-04-15 The Procter & Gamble Company Systems and methods for identifying cosmetic agents for hair/scalp care compositions
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
AU2019285066B2 (en) 2018-06-15 2024-06-13 Handa Pharmaceuticals, Inc. Kinase inhibitor salts and compositions thereof
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法

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US20120116081A1 (en) 2012-05-10
JP2008545786A (ja) 2008-12-18
CY1111428T1 (el) 2015-08-05
JP5118024B2 (ja) 2013-01-16
US8946416B2 (en) 2015-02-03
SI1924574T1 (sl) 2011-02-28
CA2610105A1 (en) 2006-12-21
GT200600217A (es) 2007-03-28
NZ563740A (en) 2011-03-31
IL187421A (en) 2011-11-30
EP1924574B1 (en) 2010-11-10
WO2006135641A3 (en) 2007-03-29
MX2007015423A (es) 2008-02-21
NO20080157L (no) 2008-01-09
ATE487709T1 (de) 2010-11-15
SA06270147B1 (ar) 2009-12-22
MA29599B1 (fr) 2008-07-01
NO340743B1 (no) 2017-06-12
US20080188656A1 (en) 2008-08-07
TNSN07463A1 (en) 2009-03-17
KR20130118394A (ko) 2013-10-29
CA2610105C (en) 2014-03-25
MY147436A (en) 2012-12-14
IL187421A0 (en) 2008-02-09
JO2636B1 (en) 2012-06-17
EP1924574A2 (en) 2008-05-28
RU2007148231A (ru) 2009-07-20
PL1924574T3 (pl) 2011-04-29
KR20080022093A (ko) 2008-03-10
KR101216249B1 (ko) 2012-12-28
US8124763B2 (en) 2012-02-28
ECSP077982A (es) 2008-01-23
EG25039A (en) 2011-07-06
DK1924574T3 (da) 2011-02-14
TWI430999B (zh) 2014-03-21
HK1117524A1 (en) 2009-01-16
PT1924574E (pt) 2011-02-08
AU2006258051A1 (en) 2006-12-21
BRPI0611663A2 (pt) 2010-09-28
AR053890A1 (es) 2007-05-23
KR101514593B1 (ko) 2015-04-22
DE602006018156D1 (de) 2010-12-23
WO2006135641A2 (en) 2006-12-21
TW200726756A (en) 2007-07-16
RU2444520C2 (ru) 2012-03-10
AU2006258051B2 (en) 2010-09-09
PE20070015A1 (es) 2007-02-06

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