KR20090087095A - 조직의 세포외공간에서 증가된 데옥시리보핵산 함량과 관련된 인간 질병을 치료하는 방법 및 이 방법을 수행하기 위한 약학 제제 - Google Patents
조직의 세포외공간에서 증가된 데옥시리보핵산 함량과 관련된 인간 질병을 치료하는 방법 및 이 방법을 수행하기 위한 약학 제제 Download PDFInfo
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- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
- C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
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| PCT/RU2006/000642 WO2008066403A1 (fr) | 2006-11-28 | 2006-11-28 | Procédé de traitement de maladies humaines accompagnées d'une teneur plus élevée d'adn dans des espaces intercellulaires et préparation médicamenteuse destinée à sa mise en oeuvre |
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| KR20090087095A true KR20090087095A (ko) | 2009-08-14 |
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| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| US8710012B2 (en) | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| EP1880733A4 (en) | 2005-04-25 | 2009-08-12 | Genkin Dmitry Dmitrievich | METHOD FOR EXTENDING THE LIFE OF A HUMAN AND ANIMALS |
| JP5372769B2 (ja) | 2006-11-28 | 2013-12-18 | シーエルエス セラピューティック リミティド | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
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| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| BR112017014433A2 (pt) | 2015-01-04 | 2018-05-15 | Protalix Ltd. | proteína dnase i modificada, processo para preparar proteína dnase i modificada e composição farmacêutica |
| ES2799515T3 (es) | 2015-05-22 | 2020-12-18 | Dmitry Dmitrievich Genkin | ADN extracelular como una diana terapéutica en la neurodegeneración |
| US10844360B2 (en) * | 2015-10-07 | 2020-11-24 | Novozymes A/S | Polypeptides |
| WO2018197547A1 (en) | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i |
| AU2019209770B2 (en) | 2018-01-16 | 2025-07-31 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity |
| WO2020006389A1 (en) * | 2018-06-29 | 2020-01-02 | Viktor Veniaminovich Tets | Compositions for modulating gut microbiota |
| US20200046809A1 (en) * | 2018-08-07 | 2020-02-13 | Bradley G. Thompson | Methods for regulating endogenous production of dnase1 |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| EP3898934A4 (en) * | 2018-12-17 | 2023-01-18 | Dennis C. Mynarcik | COMPOSITIONS AND METHODS FOR REMOVING TARTAR |
| EP4225903A1 (en) | 2020-10-07 | 2023-08-16 | Protalix Ltd. | Long-acting dnase |
| CN117999086A (zh) * | 2021-05-24 | 2024-05-07 | 普利纳斯技术公司 | 使用dna酶的治疗方案 |
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| US8431123B2 (en) * | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| RU2269356C2 (ru) * | 2003-07-14 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ лечения онкологических заболеваний |
| US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8388951B2 (en) * | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| RU2269358C2 (ru) | 2003-07-14 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ лечения генерализованных инфекций, вызываемых бактериями, или заболеваний, вызываемых грибами и простейшими, или атеросклероза, или сахарного диабета, или заболеваний, связанных с реакцией гиперчувствительности замедленного типа, или заболеваний, обусловленных мутациями генов соматических клеток |
| WO2005004904A1 (en) | 2003-07-14 | 2005-01-20 | Dmitry Dmitrievich Genkin | Method for treating diseases associated with modifications of qualitative and/ quantitative composition of blood extracellular dna (variants) |
| RU2239404C1 (ru) | 2003-09-17 | 2004-11-10 | Бессонов Дмитрий Михайлович | Способ профилактики старения организма человека |
| RU2267329C2 (ru) | 2004-03-12 | 2006-01-10 | Дмитрий Дмитриевич Генкин | Способ лечения заболеваний, сопровождающихся изменениями качественного и/или количественного состава внеклеточной днк крови (варианты) |
| RU2269357C2 (ru) | 2004-03-12 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ замедления наступления болезненных состояний, связанных с увеличением возраста человека |
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| WO2007010533A2 (en) * | 2005-07-18 | 2007-01-25 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
| RU2308968C2 (ru) | 2005-07-19 | 2007-10-27 | Дмитрий Дмитриевич Генкин | Способ лечения заболеваний человека, сопровождающихся повышенным содержанием дезоксирибонуклеиновой кислоты во внеклеточных пространствах тканей, и лекарственный препарат для его реализации |
| CN101563134A (zh) * | 2006-10-18 | 2009-10-21 | 派利尼斯有限公司 | 用于诊断和治疗男性低生育力的方法和药物组合物 |
| JP5372769B2 (ja) | 2006-11-28 | 2013-12-18 | シーエルエス セラピューティック リミティド | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
| GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
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Also Published As
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| ATE513557T1 (de) | 2011-07-15 |
| JP2010511039A (ja) | 2010-04-08 |
| IL199005A (en) | 2012-04-30 |
| US20100061971A1 (en) | 2010-03-11 |
| JP5372769B2 (ja) | 2013-12-18 |
| US8871200B2 (en) | 2014-10-28 |
| ES2369547T3 (es) | 2011-12-01 |
| EP2095825A1 (en) | 2009-09-02 |
| EP2095825B1 (en) | 2011-06-22 |
| ES2369547T8 (es) | 2012-01-05 |
| WO2008066403A1 (fr) | 2008-06-05 |
| PL2095825T3 (pl) | 2011-12-30 |
| EP2095825B8 (en) | 2012-03-28 |
| IL199005A0 (en) | 2010-02-17 |
| EP2095825A4 (en) | 2009-12-30 |
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