KR20060129549A - 라우소니아 인트라셀룰라리스의 배양, 항―라우소니아인트라셀룰라리스 백신 및 진단 시약 - Google Patents

라우소니아 인트라셀룰라리스의 배양, 항―라우소니아인트라셀룰라리스 백신 및 진단 시약 Download PDF

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KR20060129549A
KR20060129549A KR1020067024337A KR20067024337A KR20060129549A KR 20060129549 A KR20060129549 A KR 20060129549A KR 1020067024337 A KR1020067024337 A KR 1020067024337A KR 20067024337 A KR20067024337 A KR 20067024337A KR 20060129549 A KR20060129549 A KR 20060129549A
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bacteria
intracellular
cells
culture
attenuated
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KR1020067024337A
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Korean (ko)
Inventor
제프리 피 크니텔
미카엘 비이 루프
Original Assignee
베링거 인겔하임/노블 래보라토리즈, 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27041284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20060129549(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/465,337 external-priority patent/US5714375A/en
Application filed by 베링거 인겔하임/노블 래보라토리즈, 인코포레이티드 filed Critical 베링거 인겔하임/노블 래보라토리즈, 인코포레이티드
Publication of KR20060129549A publication Critical patent/KR20060129549A/ko
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
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    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/105Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/1203Gram-negative bacteria
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    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56922Campylobacter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/825Bacterial vaccine for porcine species, e.g. swine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
KR1020067024337A 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항―라우소니아인트라셀룰라리스 백신 및 진단 시약 Ceased KR20060129549A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/465,337 1995-06-05
US08/465,337 US5714375A (en) 1995-06-05 1995-06-05 Ileal symbiont intracellularis propagation in suspended host cells
US08/658,194 1996-06-04
US08/658,194 US5885823A (en) 1995-06-05 1996-06-04 Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020057003259A Division KR100758614B1 (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항-라우소니아 인트라셀룰라리스 백신 및 진단시약

Publications (1)

Publication Number Publication Date
KR20060129549A true KR20060129549A (ko) 2006-12-15

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ID=27041284

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020067024337A Ceased KR20060129549A (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항―라우소니아인트라셀룰라리스 백신 및 진단 시약
KR1019970708990A Expired - Lifetime KR100513481B1 (ko) 1995-06-05 1996-06-05 라우소니아인트라셀루라리스의배양,항-라우소니아인트라셀룰라리스백신및진단시약
KR1020057003259A Expired - Lifetime KR100758614B1 (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항-라우소니아 인트라셀룰라리스 백신 및 진단시약
KR1020057005243A Expired - Lifetime KR100544857B1 (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항-라우소니아인트라셀룰라리스 백신 및 진단시약

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1019970708990A Expired - Lifetime KR100513481B1 (ko) 1995-06-05 1996-06-05 라우소니아인트라셀루라리스의배양,항-라우소니아인트라셀룰라리스백신및진단시약
KR1020057003259A Expired - Lifetime KR100758614B1 (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항-라우소니아 인트라셀룰라리스 백신 및 진단시약
KR1020057005243A Expired - Lifetime KR100544857B1 (ko) 1995-06-05 1996-06-05 라우소니아 인트라셀룰라리스의 배양, 항-라우소니아인트라셀룰라리스 백신 및 진단시약

Country Status (23)

Country Link
US (1) US5885823A (https=)
EP (5) EP1645567B2 (https=)
JP (4) JP3765834B2 (https=)
KR (4) KR20060129549A (https=)
AT (3) ATE289069T1 (https=)
AU (1) AU717045B2 (https=)
BG (1) BG64292B1 (https=)
BR (2) BRPI9612938B8 (https=)
CA (1) CA2222643C (https=)
CZ (1) CZ295933B6 (https=)
DE (5) DE122007000102I1 (https=)
DK (3) DK1403643T3 (https=)
ES (3) ES2294620T5 (https=)
FR (1) FR07C0071I2 (https=)
HU (1) HU230199B1 (https=)
LU (1) LU91405I2 (https=)
NL (1) NL300331I2 (https=)
NZ (1) NZ319994A (https=)
PL (6) PL189287B1 (https=)
PT (3) PT843818E (https=)
RO (1) RO118885B1 (https=)
RU (2) RU2265849C2 (https=)
WO (1) WO1996039629A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE329031T1 (de) * 1995-11-30 2006-06-15 Agriculture Victoria Serv Pty Therapeutische zusammensetzungen zur behandlung von lawsonia intracellularis infektionen
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
CA2372105A1 (en) * 1999-05-13 2000-11-23 Pfizer Products Inc. Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses
JP2003516113A (ja) * 1999-05-13 2003-05-13 ファイザー プロダクツ インコーポレーティッド ローソニア由来の遺伝子及び関連FlgEポリペプチド、ぺプチド及びタンパク質並びにそれらの使用
US7052697B1 (en) * 1999-05-13 2006-05-30 Agriculture Victoria Services Pty Ltd Lawsonia derived gene and related OmpH polypeptides, peptides and proteins and their uses
US7029683B1 (en) 1999-05-13 2006-04-18 Pfizer Products, Inc. Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses
JP2003501013A (ja) * 1999-05-13 2003-01-14 ファイザー プロダクツ インコーポレーティッド ローソニア由来の遺伝子及び関連SodCポリペプチド、ぺプチド及びタンパク質並びにそれらの使用
MXPA01011570A (es) * 1999-05-13 2003-08-20 Australian Pork Ltd Gen derivado de lawsonia y polipeptidos, peptidos y proteinas relacionadas con peptido h de membrana externa.
US6605696B1 (en) * 1999-10-22 2003-08-12 Pfizer, Inc. Lawsonia intracellularis proteins, and related methods and materials
CA2423588A1 (en) * 2000-09-29 2002-04-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Improved vaccines for proliferative ileitis and methods of making and using the same
AUPR138100A0 (en) 2000-11-10 2000-12-07 Agriculture Victoria Services Pty Ltd Novel therapeutic compositions for treating infection by lawsonia spp
JP2004512851A (ja) * 2000-11-10 2004-04-30 アグリカルチュア ビクトリア サービシーズプロプライエトリー リミティッド ラウソニア種による感染を処置する新規な治療用組成物
ES2360225T3 (es) * 2000-12-20 2011-06-02 Intervet International Bv Vacuna contra lawsonia intracellularis.
US20030087421A1 (en) * 2001-07-11 2003-05-08 Gebhart Connie J Lawsonia intracellularis
CA2501238A1 (en) * 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
KR101131845B1 (ko) * 2003-07-25 2012-03-30 베링거잉겔하임베트메디카인코퍼레이티드 유럽 기원의 로소니아 인트라셀룰라리스, 및 이의 백신,진단제 및 사용 방법
CA2536989A1 (en) * 2003-09-12 2005-03-24 Akzo Nobel N.V. Lawsonia intracellularis subunit vaccine
KR20060112674A (ko) * 2003-12-09 2006-11-01 인터벳 인터내셔널 비.브이. 로소니아 인트라셀룰라리스 26 kd 서브유닛 백신
CA2554472A1 (en) * 2004-01-22 2005-08-04 Intervet International B.V. Lawsonia intracellularis subunit vaccines
MY146476A (en) 2004-06-24 2012-08-15 Boehringer Ingelheim Vetmed Method of diagnosing lawsonia intracellularis
EP1609870A1 (en) * 2004-06-24 2005-12-28 Boehringer Ingelheim Vetmedica Gmbh Method of diagnosing lawsonia intracellularis
US20060021536A1 (en) * 2004-07-30 2006-02-02 Limin Song Method for creating an absorbent article exhibiting a harmonic color scheme
KR100621882B1 (ko) * 2004-09-30 2006-09-19 건국대학교 산학협력단 돼지 증식성 회장염 감염돈에서 로소니아인트라셀룰라리스 균을 분리하는 방법
AU2005308583A1 (en) * 2004-11-24 2006-06-01 Pharmacia & Upjohn Company Llc Methods for cultivating Lawsonia intracellularis
US20070212373A1 (en) * 2004-12-08 2007-09-13 Akzo Nobel N.V. Lawsonia Intracellularis 26 Kd Subunit Vaccine
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
EP1968630B1 (en) 2005-12-29 2018-01-24 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
MX338626B (es) 2005-12-29 2016-04-26 Boehringer Ingelheim Vetmed Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos.
US8470336B2 (en) * 2006-05-25 2013-06-25 Boehringer Ingelheim Vetmedica, Inc. Vaccination of young animals against Lawsonia intracellularis infections
US20080241190A1 (en) * 2006-11-13 2008-10-02 Boehringer Ingelheim Vetmedica, Inc. Vaccination of horses against lawsonia intracellularis
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
JP5200223B2 (ja) * 2006-12-15 2013-06-05 ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド Pcv2抗原によるブタの処置
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
WO2009037262A2 (en) 2007-09-17 2009-03-26 Boehringer Ingelheim Vetmedica, Inc. Method of preventing early lawsonia intracellularis infections
MX2010003879A (es) * 2007-10-12 2010-04-30 Pfizer Metodos de cultivo de lawsonia intracellularis.
WO2009088950A2 (en) * 2007-12-31 2009-07-16 Boehringer Ingelheim Vetmedica, Inc. Pcv2 orf2 virus like particle with foreign amino acid insertion
KR20100113582A (ko) * 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
US20110033495A1 (en) * 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌(Lawsonia intracellularis)用疫苗
TWI449533B (zh) 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗
US8557254B2 (en) 2008-07-22 2013-10-15 Intervet Inc. Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies
US8142760B2 (en) * 2008-09-05 2012-03-27 Nathan Len Winkelman Vaccination for Lawsonia intracellularis
WO2011006880A1 (en) * 2009-07-14 2011-01-20 Intervet International B.V. Lawsonia intracellularis propagation
AR078253A1 (es) * 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
US8530223B2 (en) * 2009-11-09 2013-09-10 Intervet International B.V. Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells
PT2938747T (pt) 2012-12-28 2019-08-01 Boehringer Ingelheim Vetmedica Gmbh Método de preparação de uma vacina de micoplasma
EP3049106A1 (en) 2013-09-25 2016-08-03 Zoetis Services LLC Pcv2b divergent vaccine composition and methods of use
US9505808B2 (en) 2013-10-02 2016-11-29 Boehringer Ingelheim Vetmedica, Inc. PCV2 ORF2 protein variant and virus like particles composed thereof
US10751405B2 (en) 2015-02-04 2020-08-25 Intervet Inc. Vaccine for use against subclinical Lawsonia infection in a pig
ES2798282T3 (es) 2015-02-04 2020-12-10 Intervet Int Bv Una vacuna para usar contra la infección asintomática por Lawsonia en un cerdo
KR20180062468A (ko) * 2016-11-18 2018-06-11 녹십자수의약품(주) 신규한 로소니아 인트라셀룰라리스 균주 및 이의 용도
BR112020017520A2 (pt) 2018-02-28 2020-12-22 Boehringer Ingelheim Vetmedica Gmbh Método para redução de escatol e/ou indol em animais
JP7657287B2 (ja) 2020-07-24 2025-04-04 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 組合せブタワクチン
MX2024005116A (es) 2021-11-01 2024-05-16 Boehringer Ingelheim Vetmedica Gmbh Composiciones de gel inmunogenas.
WO2024068637A1 (en) * 2022-09-27 2024-04-04 Intervet International B.V. A method of culturing lawsonia intracellularis bacteria
WO2024260953A1 (en) * 2023-06-23 2024-12-26 Intervet International B.V. A method of culturing lawsonia intracellularis bacteria
CN119185351B (zh) * 2024-09-25 2025-09-16 武汉轻工大学 Li0004蛋白靶点在制备抑制劳森菌感染细胞增殖的药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132597A (en) * 1976-06-09 1979-01-02 Ab Medipharm Method for cultivation of bacteria
US4237218A (en) * 1979-02-09 1980-12-02 Bio-Rad Laboratories, Inc. Micro-carrier cell culture
JPS5991879A (ja) * 1982-11-16 1984-05-26 Hideaki Yamada シユ−ドモナス属細菌の培養法
DK594084A (da) * 1984-12-12 1986-06-13 Novo Industri As Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
JPH0644865B2 (ja) * 1985-10-29 1994-06-15 三菱瓦斯化学株式会社 カンピロバクタ−属細菌の培養方法
US5338670A (en) * 1986-07-28 1994-08-16 The United States Of America As Represented By The Department Of Health And Human Services Production of bordetella pertussis toxin with a low concentration of iron
IT1227657B (it) * 1988-12-01 1991-04-23 Mini Ricerca Scient Tecnolog Antibiotici ab-021 e processo per la loro produzione
JPH0822221B2 (ja) * 1988-12-28 1996-03-06 日東化学工業株式会社 シュードモナス属細菌の培養法
JPH02308754A (ja) * 1989-05-24 1990-12-21 Yakult Honsha Co Ltd 乳発酵食品の製造法
US5296221A (en) * 1990-01-31 1994-03-22 Sani-Ei Sucrochemical Co., Ltd. Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations
CA2094515C (en) * 1990-11-01 1998-09-01 Theodore T. Kramer Bacterial attenuation method and vaccine
SU1768637A1 (en) * 1990-12-04 1992-10-15 Inst Virusologii Im D I Ivanov Strain of human immunodeficient virus 1-type for preparation of diagnostic preparation
EP0669971B1 (en) * 1991-11-15 2003-03-19 Pfizer Inc. Method of producing gram-negative bacterial vaccines
DE4208785A1 (de) * 1992-03-19 1993-09-23 Degussa Verfahren zum auffinden von insertionselementen (is-elemente) oder transposonen
US5610059A (en) * 1992-11-09 1997-03-11 University Of Arizona Etiological agent for porcine enteritis

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