KR20020059398A - 양성 친화성 프로드럭 - Google Patents
양성 친화성 프로드럭 Download PDFInfo
- Publication number
- KR20020059398A KR20020059398A KR1020027003276A KR20027003276A KR20020059398A KR 20020059398 A KR20020059398 A KR 20020059398A KR 1020027003276 A KR1020027003276 A KR 1020027003276A KR 20027003276 A KR20027003276 A KR 20027003276A KR 20020059398 A KR20020059398 A KR 20020059398A
- Authority
- KR
- South Korea
- Prior art keywords
- prodrug
- etoposide
- therapeutic compound
- formula
- oligomer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15364999P | 1999-09-13 | 1999-09-13 | |
US60/153,649 | 1999-09-13 | ||
US09/474,915 | 1999-12-31 | ||
US09/474,915 US6713454B1 (en) | 1999-09-13 | 1999-12-31 | Prodrugs of etoposide and etoposide analogs |
PCT/US2000/024520 WO2001019406A2 (en) | 1999-09-13 | 2000-09-07 | Amphiphilic prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20020059398A true KR20020059398A (ko) | 2002-07-12 |
Family
ID=26850733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027003276A KR20020059398A (ko) | 1999-09-13 | 2000-09-07 | 양성 친화성 프로드럭 |
Country Status (17)
Families Citing this family (58)
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US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
WO2001024831A2 (en) * | 1999-10-04 | 2001-04-12 | Shearwater Corporation | Polymer stabilized neuropeptides |
US6703417B2 (en) * | 2000-04-15 | 2004-03-09 | Byung-Wook Jo | Aqueous-prodrug compound comprising moiety of paclitaxel or derivatives thereof, method of preparing same and pharmaceutical composition comprising same |
US7087641B2 (en) * | 2002-03-28 | 2006-08-08 | Council Of Scientific & Industrial Research | 4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
KR20050074493A (ko) * | 2002-10-21 | 2005-07-18 | 라모트 앳 텔-아비브 유니버시티 리미티드 | 칼륨 채널 및/또는 피질 뉴우런 작용 조절제로서 유용한n-페닐안트라닐산 및/또는 2-벤즈이미다졸론의 유도체 |
CA2504287A1 (en) * | 2002-11-26 | 2004-06-10 | Nobex Corporation | Natriuretic compounds, conjugates, and uses thereof |
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JP5173199B2 (ja) * | 2006-01-16 | 2013-03-27 | 株式会社アイ・ティー・オー | 創傷治癒用高分子組成物 |
WO2007111211A1 (ja) | 2006-03-28 | 2007-10-04 | Nippon Kayaku Kabushiki Kaisha | タキサン類の高分子結合体 |
CA2652656A1 (en) * | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
JP5548364B2 (ja) * | 2006-10-03 | 2014-07-16 | 日本化薬株式会社 | レゾルシノール誘導体の高分子結合体 |
JP5503872B2 (ja) | 2006-11-06 | 2014-05-28 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
EP2090607B1 (en) | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
US8920788B2 (en) * | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
MX355683B (es) * | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
CN102159203A (zh) * | 2008-07-23 | 2011-08-17 | 麻省理工学院 | 组蛋白脱乙酰酶1(hdac1)的活化防范dna损伤和增加神经元存活 |
AU2009304560A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of GLP-1 agonists and uses thereof |
CN102245636A (zh) | 2008-10-15 | 2011-11-16 | 安吉奥开米公司 | 用于药物递送的依托泊苷和多柔比星结合物 |
AU2009322043A1 (en) * | 2008-12-05 | 2011-07-07 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
CA2747220A1 (en) | 2008-12-17 | 2010-06-24 | Richard Beliveau | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
ES2729261T3 (es) | 2009-04-20 | 2019-10-31 | Angiochem Inc | Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2 |
JP5544357B2 (ja) | 2009-05-15 | 2014-07-09 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
CA2766537A1 (en) | 2009-07-02 | 2011-01-06 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
CN102834002A (zh) | 2009-10-30 | 2012-12-19 | 麻省理工学院 | Ci-994和地那林用于治疗记忆/认知和焦虑病症的用途 |
EP2525831B1 (en) * | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
WO2011141891A1 (en) | 2010-05-12 | 2011-11-17 | Debio Recherche Pharmaceutique S.A. | Use of cycloundecadepsipeptide compounds |
WO2012048204A2 (en) * | 2010-10-08 | 2012-04-12 | Virginia Commonwealth University | Prodrugs utilizing a transporter directed uptake mechanism |
JP5856069B2 (ja) | 2010-11-17 | 2016-02-09 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
EP2701699B1 (en) | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
RS58438B1 (sr) | 2011-07-22 | 2019-04-30 | Massachusetts Inst Technology | Aktivatori klase i histonskih deacetilaza (hdacs) i njihova primena |
US9346923B2 (en) | 2011-09-11 | 2016-05-24 | Nippon Kayaku Kabushiki Kaisha | Method for manufacturing block copolymer |
US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
EP2852439A1 (en) | 2012-05-23 | 2015-04-01 | Stemergie Biotechnology SA | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
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WO2016205631A1 (en) | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders |
US20190085029A1 (en) | 2017-09-18 | 2019-03-21 | Massachusetts Institute Of Technology | Cyclin-dependent kinase 5 (cdk5) inhibitory peptides |
CN112266409B (zh) * | 2020-10-28 | 2022-05-13 | 南开大学 | 依托泊苷自组装纳米纤维多肽、制备方法及应用 |
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-
1999
- 1999-12-31 US US09/474,915 patent/US6713454B1/en not_active Expired - Fee Related
-
2000
- 2000-09-07 HU HU0204110A patent/HUP0204110A3/hu unknown
- 2000-09-07 RU RU2002109595/14A patent/RU2002109595A/ru not_active Application Discontinuation
- 2000-09-07 CN CN00815508A patent/CN1390143A/zh active Pending
- 2000-09-07 JP JP2001523037A patent/JP2003509385A/ja active Pending
- 2000-09-07 WO PCT/US2000/024520 patent/WO2001019406A2/en not_active Application Discontinuation
- 2000-09-07 CA CA002384645A patent/CA2384645A1/en not_active Abandoned
- 2000-09-07 KR KR1020027003276A patent/KR20020059398A/ko not_active Application Discontinuation
- 2000-09-07 IL IL14855800A patent/IL148558A0/xx unknown
- 2000-09-07 AU AU75756/00A patent/AU7575600A/en not_active Abandoned
- 2000-09-07 EP EP00964949A patent/EP1212099A2/en not_active Withdrawn
- 2000-09-07 NZ NZ517681A patent/NZ517681A/en unknown
- 2000-09-07 PL PL00354261A patent/PL354261A1/xx not_active Application Discontinuation
- 2000-09-07 CZ CZ2002928A patent/CZ2002928A3/cs unknown
- 2000-09-07 MX MXPA02002712A patent/MXPA02002712A/es unknown
- 2000-09-07 BR BR0013948-3A patent/BR0013948A/pt not_active IP Right Cessation
-
2002
- 2002-03-12 NO NO20021213A patent/NO20021213L/no not_active Application Discontinuation
-
2004
- 2004-03-24 US US10/808,044 patent/US7119074B2/en not_active Expired - Fee Related
- 2004-03-29 US US10/811,760 patent/US20040253206A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6713454B1 (en) | 2004-03-30 |
CN1390143A (zh) | 2003-01-08 |
WO2001019406A3 (en) | 2002-01-17 |
CA2384645A1 (en) | 2001-03-22 |
BR0013948A (pt) | 2002-05-14 |
RU2002109595A (ru) | 2003-11-27 |
HUP0204110A3 (en) | 2003-08-28 |
JP2003509385A (ja) | 2003-03-11 |
WO2001019406A2 (en) | 2001-03-22 |
HUP0204110A2 (hu) | 2003-04-28 |
IL148558A0 (en) | 2002-09-12 |
EP1212099A2 (en) | 2002-06-12 |
CZ2002928A3 (cs) | 2002-09-11 |
NO20021213L (no) | 2002-05-13 |
MXPA02002712A (es) | 2003-10-14 |
PL354261A1 (en) | 2003-12-29 |
US20040180840A1 (en) | 2004-09-16 |
NO20021213D0 (no) | 2002-03-12 |
US7119074B2 (en) | 2006-10-10 |
AU7575600A (en) | 2001-04-17 |
US20040253206A1 (en) | 2004-12-16 |
NZ517681A (en) | 2004-01-30 |
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