HUP0204110A3 - Amphiphilic prodrugs, process for preparation and use of pharmaceutical compositions containing them - Google Patents
Amphiphilic prodrugs, process for preparation and use of pharmaceutical compositions containing themInfo
- Publication number
- HUP0204110A3 HUP0204110A3 HU0204110A HUP0204110A HUP0204110A3 HU P0204110 A3 HUP0204110 A3 HU P0204110A3 HU 0204110 A HU0204110 A HU 0204110A HU P0204110 A HUP0204110 A HU P0204110A HU P0204110 A3 HUP0204110 A3 HU P0204110A3
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- amphiphilic prodrugs
- amphiphilic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15364999P | 1999-09-13 | 1999-09-13 | |
US09/474,915 US6713454B1 (en) | 1999-09-13 | 1999-12-31 | Prodrugs of etoposide and etoposide analogs |
PCT/US2000/024520 WO2001019406A2 (en) | 1999-09-13 | 2000-09-07 | Amphiphilic prodrugs |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0204110A2 HUP0204110A2 (hu) | 2003-04-28 |
HUP0204110A3 true HUP0204110A3 (en) | 2003-08-28 |
Family
ID=26850733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204110A HUP0204110A3 (en) | 1999-09-13 | 2000-09-07 | Amphiphilic prodrugs, process for preparation and use of pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
US (3) | US6713454B1 (hu) |
EP (1) | EP1212099A2 (hu) |
JP (1) | JP2003509385A (hu) |
KR (1) | KR20020059398A (hu) |
CN (1) | CN1390143A (hu) |
AU (1) | AU7575600A (hu) |
BR (1) | BR0013948A (hu) |
CA (1) | CA2384645A1 (hu) |
CZ (1) | CZ2002928A3 (hu) |
HU (1) | HUP0204110A3 (hu) |
IL (1) | IL148558A0 (hu) |
MX (1) | MXPA02002712A (hu) |
NO (1) | NO20021213L (hu) |
NZ (1) | NZ517681A (hu) |
PL (1) | PL354261A1 (hu) |
RU (1) | RU2002109595A (hu) |
WO (1) | WO2001019406A2 (hu) |
Families Citing this family (58)
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US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
US6541508B2 (en) * | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
WO2001024831A2 (en) | 1999-10-04 | 2001-04-12 | Shearwater Corporation | Polymer stabilized neuropeptides |
AU2001252711A1 (en) * | 2000-04-15 | 2001-10-30 | Byung-Wook Jo | Aqueous-prodrug compound comprising moiety of paclitxel or derivatives thereof, method of preparing same and pharmaceutical composition comprising same |
AU2002249559A1 (en) * | 2002-03-28 | 2003-10-13 | Council Of Scientific And Industrial Research | 4-beta-1''-`(2''-(substituted benzoyl)anilino! podophyllotoxin analogues useful as anticancer agents |
AU2003272068A1 (en) * | 2002-10-21 | 2004-05-04 | Ramot At Tel Aviv University Ltd. | Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
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CN102895666B (zh) * | 2003-12-16 | 2015-08-19 | 尼克塔治疗公司 | 化学改性的小分子 |
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JP5173199B2 (ja) * | 2006-01-16 | 2013-03-27 | 株式会社アイ・ティー・オー | 創傷治癒用高分子組成物 |
WO2007111211A1 (ja) | 2006-03-28 | 2007-10-04 | Nippon Kayaku Kabushiki Kaisha | タキサン類の高分子結合体 |
RU2447095C2 (ru) * | 2006-05-18 | 2012-04-10 | Ниппон Каяку Кабусики Кайся | Высокомолекулярный конъюгат подофиллотоксинов |
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JP5503872B2 (ja) | 2006-11-06 | 2014-05-28 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
WO2009037707A2 (en) | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
CN101808651B (zh) * | 2007-09-28 | 2013-03-27 | 日本化药株式会社 | 类固醇类的高分子结合物 |
CN101977631A (zh) * | 2008-03-18 | 2011-02-16 | 日本化药株式会社 | 生理活性物质的高分子量偶联物 |
MX355683B (es) * | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
AU2009274571A1 (en) * | 2008-07-23 | 2010-01-28 | Massachusetts Institute Of Technology | Activation of histone deacetylase 1 (HDAC1) protects against DNA damage and increases neuronal survival |
MX2011004019A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de etoposido y doxorubicina para entrega de farmacos. |
EP2346906A4 (en) | 2008-10-15 | 2013-04-24 | Angiochem Inc | CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE |
BRPI0922689A2 (pt) * | 2008-12-05 | 2018-11-06 | Angiochem Inc. | conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos |
CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
EP2431403B1 (en) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
EP2448965A4 (en) | 2009-07-02 | 2015-02-11 | Angiochem Inc | MULTIMEPEPTID CONJUGATES AND ITS USES |
WO2011053876A1 (en) | 2009-10-30 | 2011-05-05 | Massachusetts Institute Of Technology | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
WO2011089214A1 (en) * | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
WO2011141891A1 (en) | 2010-05-12 | 2011-11-17 | Debio Recherche Pharmaceutique S.A. | Use of cycloundecadepsipeptide compounds |
WO2012048204A2 (en) * | 2010-10-08 | 2012-04-12 | Virginia Commonwealth University | Prodrugs utilizing a transporter directed uptake mechanism |
WO2012067138A1 (ja) | 2010-11-17 | 2012-05-24 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
WO2012149540A1 (en) | 2011-04-28 | 2012-11-01 | The Broad Institute Inc | Inhibitors of histone deacetylase |
WO2013016193A2 (en) | 2011-07-22 | 2013-01-31 | Massachusetts Istitute Of Technology | Activators of class i histone deacetlyases (hdacs) and uses thereof |
RU2623426C2 (ru) | 2011-09-11 | 2017-06-26 | Ниппон Каяку Кабусики Кайся | Способ получения блок-сополимера |
US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
EP2852439A1 (en) | 2012-05-23 | 2015-04-01 | Stemergie Biotechnology SA | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
WO2014100438A1 (en) | 2012-12-20 | 2014-06-26 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
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US20170007618A1 (en) | 2015-06-17 | 2017-01-12 | Massachusetts Institute Of Technology | Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders |
WO2019055236A1 (en) | 2017-09-18 | 2019-03-21 | Massachusetts Institute Of Technology | PEPTIDES CYCLIN DEPENDENT KINASE 5 INHIBITORS (CDK5) |
CN112266409B (zh) * | 2020-10-28 | 2022-05-13 | 南开大学 | 依托泊苷自组装纳米纤维多肽、制备方法及应用 |
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US6380405B1 (en) * | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
-
1999
- 1999-12-31 US US09/474,915 patent/US6713454B1/en not_active Expired - Fee Related
-
2000
- 2000-09-07 RU RU2002109595/14A patent/RU2002109595A/ru not_active Application Discontinuation
- 2000-09-07 CA CA002384645A patent/CA2384645A1/en not_active Abandoned
- 2000-09-07 KR KR1020027003276A patent/KR20020059398A/ko not_active Application Discontinuation
- 2000-09-07 CN CN00815508A patent/CN1390143A/zh active Pending
- 2000-09-07 MX MXPA02002712A patent/MXPA02002712A/es unknown
- 2000-09-07 JP JP2001523037A patent/JP2003509385A/ja active Pending
- 2000-09-07 CZ CZ2002928A patent/CZ2002928A3/cs unknown
- 2000-09-07 BR BR0013948-3A patent/BR0013948A/pt not_active IP Right Cessation
- 2000-09-07 IL IL14855800A patent/IL148558A0/xx unknown
- 2000-09-07 PL PL00354261A patent/PL354261A1/xx not_active Application Discontinuation
- 2000-09-07 NZ NZ517681A patent/NZ517681A/en unknown
- 2000-09-07 EP EP00964949A patent/EP1212099A2/en not_active Withdrawn
- 2000-09-07 HU HU0204110A patent/HUP0204110A3/hu unknown
- 2000-09-07 WO PCT/US2000/024520 patent/WO2001019406A2/en not_active Application Discontinuation
- 2000-09-07 AU AU75756/00A patent/AU7575600A/en not_active Abandoned
-
2002
- 2002-03-12 NO NO20021213A patent/NO20021213L/no not_active Application Discontinuation
-
2004
- 2004-03-24 US US10/808,044 patent/US7119074B2/en not_active Expired - Fee Related
- 2004-03-29 US US10/811,760 patent/US20040253206A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU7575600A (en) | 2001-04-17 |
EP1212099A2 (en) | 2002-06-12 |
US20040180840A1 (en) | 2004-09-16 |
CN1390143A (zh) | 2003-01-08 |
MXPA02002712A (es) | 2003-10-14 |
IL148558A0 (en) | 2002-09-12 |
NZ517681A (en) | 2004-01-30 |
CA2384645A1 (en) | 2001-03-22 |
RU2002109595A (ru) | 2003-11-27 |
JP2003509385A (ja) | 2003-03-11 |
US20040253206A1 (en) | 2004-12-16 |
HUP0204110A2 (hu) | 2003-04-28 |
BR0013948A (pt) | 2002-05-14 |
KR20020059398A (ko) | 2002-07-12 |
NO20021213D0 (no) | 2002-03-12 |
WO2001019406A2 (en) | 2001-03-22 |
US7119074B2 (en) | 2006-10-10 |
US6713454B1 (en) | 2004-03-30 |
NO20021213L (no) | 2002-05-13 |
WO2001019406A3 (en) | 2002-01-17 |
PL354261A1 (en) | 2003-12-29 |
CZ2002928A3 (cs) | 2002-09-11 |
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