BR0013948A - Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero - Google Patents

Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero

Info

Publication number
BR0013948A
BR0013948A BR0013948-3A BR0013948A BR0013948A BR 0013948 A BR0013948 A BR 0013948A BR 0013948 A BR0013948 A BR 0013948A BR 0013948 A BR0013948 A BR 0013948A
Authority
BR
Brazil
Prior art keywords
treatment
pharmaceutical composition
mammalian patient
prodrug
drug delivery
Prior art date
Application number
BR0013948-3A
Other languages
English (en)
Inventor
Nnochiri N Ekwuribe
Tatyana A Dyakonov
Christopher H Price
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of BR0013948A publication Critical patent/BR0013948A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

"PRODROGA, COMPOSIçãO FARMACêUTICA, E, MéTODO DE TRATAMENTO DE UM PACIENTE MAMìFERO". A presente invenção provê prodrogas anfifílicas, que compreendem um composto terapêutico conjugado a um oligómero/ polímero de PEG e a métodos para o uso das referidas prodrogas para permitir o fornecimento de droga oral e/ou o fornecimento de drogas através da barreira da corrente sanguinea ao interior do sistema nervoso central.
BR0013948-3A 1999-09-13 2000-09-07 Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero BR0013948A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15364999P 1999-09-13 1999-09-13
US09/474,915 US6713454B1 (en) 1999-09-13 1999-12-31 Prodrugs of etoposide and etoposide analogs
PCT/US2000/024520 WO2001019406A2 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs

Publications (1)

Publication Number Publication Date
BR0013948A true BR0013948A (pt) 2002-05-14

Family

ID=26850733

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013948-3A BR0013948A (pt) 1999-09-13 2000-09-07 Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero

Country Status (17)

Country Link
US (3) US6713454B1 (pt)
EP (1) EP1212099A2 (pt)
JP (1) JP2003509385A (pt)
KR (1) KR20020059398A (pt)
CN (1) CN1390143A (pt)
AU (1) AU7575600A (pt)
BR (1) BR0013948A (pt)
CA (1) CA2384645A1 (pt)
CZ (1) CZ2002928A3 (pt)
HU (1) HUP0204110A3 (pt)
IL (1) IL148558A0 (pt)
MX (1) MXPA02002712A (pt)
NO (1) NO20021213L (pt)
NZ (1) NZ517681A (pt)
PL (1) PL354261A1 (pt)
RU (1) RU2002109595A (pt)
WO (1) WO2001019406A2 (pt)

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Also Published As

Publication number Publication date
WO2001019406A2 (en) 2001-03-22
NO20021213L (no) 2002-05-13
NO20021213D0 (no) 2002-03-12
CZ2002928A3 (cs) 2002-09-11
HUP0204110A2 (hu) 2003-04-28
HUP0204110A3 (en) 2003-08-28
US7119074B2 (en) 2006-10-10
EP1212099A2 (en) 2002-06-12
IL148558A0 (en) 2002-09-12
AU7575600A (en) 2001-04-17
CA2384645A1 (en) 2001-03-22
JP2003509385A (ja) 2003-03-11
US20040180840A1 (en) 2004-09-16
KR20020059398A (ko) 2002-07-12
CN1390143A (zh) 2003-01-08
WO2001019406A3 (en) 2002-01-17
RU2002109595A (ru) 2003-11-27
US20040253206A1 (en) 2004-12-16
PL354261A1 (en) 2003-12-29
NZ517681A (en) 2004-01-30
US6713454B1 (en) 2004-03-30
MXPA02002712A (es) 2003-10-14

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