KR20010071572A - 발프로산 유사체를 편두통 및 기분 장애의 치료 및 예방에사용하는 용도 - Google Patents
발프로산 유사체를 편두통 및 기분 장애의 치료 및 예방에사용하는 용도 Download PDFInfo
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- KR20010071572A KR20010071572A KR1020007014630A KR20007014630A KR20010071572A KR 20010071572 A KR20010071572 A KR 20010071572A KR 1020007014630 A KR1020007014630 A KR 1020007014630A KR 20007014630 A KR20007014630 A KR 20007014630A KR 20010071572 A KR20010071572 A KR 20010071572A
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- Prior art keywords
- acid
- propyl
- migraine
- hexic
- valproic acid
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- 230000000737 periodic effect Effects 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- VJKUPQSHOVKBCO-AHMKVGDJSA-N picrotoxin Chemical compound O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(=C)C)[C@@H]1C(=O)O2.O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(C)(O)C)[C@@H]1C(=O)O2 VJKUPQSHOVKBCO-AHMKVGDJSA-N 0.000 description 1
- 230000005371 pilomotor reflex Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010825 rotarod performance test Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000018316 severe headache Diseases 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9028198P | 1998-06-22 | 1998-06-22 | |
US60/090,281 | 1998-06-22 | ||
PCT/US1999/014081 WO1999066920A1 (fr) | 1998-06-22 | 1999-06-22 | Utilisation d'un analogue d'acide valproique dans le traitement et la prevention de migraine et de maladies affectives |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20010071572A true KR20010071572A (ko) | 2001-07-28 |
Family
ID=22222101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020007014630A KR20010071572A (ko) | 1998-06-22 | 1999-06-22 | 발프로산 유사체를 편두통 및 기분 장애의 치료 및 예방에사용하는 용도 |
Country Status (19)
Country | Link |
---|---|
US (2) | US6268396B1 (fr) |
EP (1) | EP1089725A1 (fr) |
JP (1) | JP2002518442A (fr) |
KR (1) | KR20010071572A (fr) |
CN (1) | CN1310622A (fr) |
AU (2) | AU752192B2 (fr) |
BG (1) | BG63744B1 (fr) |
BR (1) | BR9911421A (fr) |
CA (1) | CA2335641A1 (fr) |
CZ (1) | CZ20004833A3 (fr) |
HU (1) | HUP0102456A3 (fr) |
IL (1) | IL140415A0 (fr) |
MX (1) | MXPA00012808A (fr) |
NO (1) | NO20006506L (fr) |
PL (1) | PL345364A1 (fr) |
SK (1) | SK19992000A3 (fr) |
TR (2) | TR200003800T2 (fr) |
WO (1) | WO1999066920A1 (fr) |
ZA (1) | ZA200007652B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6104802A (en) | 1997-02-10 | 2000-08-15 | Genesys Telecommunications Laboratories, Inc. | In-band signaling for routing |
ES2228521T3 (es) | 1999-05-04 | 2005-04-16 | Keith R. Edwards | Valproato intravenoso para el tratamiento agudo de la jaqueca. |
CZ2004266A3 (cs) | 2000-07-21 | 2005-02-16 | Teva Pharmaceutical Industries, Ltd. | Použití derivátů amidů kyseliny valproové a kyseliny 2-valproenové pro léčbu mánie při bipolární poruše |
WO2002013766A2 (fr) * | 2000-08-17 | 2002-02-21 | Teva Pharmaceutical Industries, Ltd. | Utilisation de derives d'amides d'acide valproique et d'amides d'acide 2-valproenique pour le traitement ou la prevention de la douleur et/ou des cephalees |
US20020103110A1 (en) * | 2001-01-26 | 2002-08-01 | Spitzer A. Robert | System and method for rectal administration of medication for treatment of migraines |
US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
WO2004037843A2 (fr) * | 2002-10-25 | 2004-05-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Composes steroides comprenant des groupes mimetiques de la superoxyde dismutase et des groupes donneurs d'oxyde nitrique, et leur utilisation dans la preparation de medicaments |
WO2004050084A2 (fr) * | 2002-11-29 | 2004-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Inhibiteurs d'enzyme de conversion de l'angiotensine possedant une activite antioxydante et de donneur d'oxyde nitrique (no) |
AU2003289782A1 (en) * | 2002-12-16 | 2004-07-09 | The University Of British Columbia | Valproic acid analogues and pharmaceutical compositions thereof |
EP1543831A1 (fr) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Composition de pregabaline |
US20060025477A1 (en) * | 2004-07-22 | 2006-02-02 | Artman Linda D | Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases |
WO2007028030A2 (fr) * | 2005-09-02 | 2007-03-08 | Picobella, Llc | Arn regulateurs oncogenes pour le diagnostic et la therapie |
US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
CA2872976A1 (fr) * | 2012-05-08 | 2013-11-14 | Cellixbio Private Limited | Compositions et methodes de traitement de troubles neurologiques |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2442M (fr) | 1962-10-17 | 1964-04-06 | Henry Eugene | L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central. |
US3701729A (en) | 1970-06-01 | 1972-10-31 | Tenneco Chem | Oil-soluble mixed copper soap products |
US3847956A (en) | 1973-04-06 | 1974-11-12 | Us Agriculture | 2-hydroperoxycarboxylic acids and their preparation |
US3932285A (en) | 1973-10-03 | 1976-01-13 | Tenneco Chemicals, Inc. | Chromium salt compositions and a process for their production |
US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
US4129599A (en) | 1975-04-28 | 1978-12-12 | The Board Of Trustees Of Leland Stanford Jr. University | A-Norsteroids |
JPS5680116A (en) | 1979-12-05 | 1981-07-01 | Sanyo Electric Co Ltd | Manufacture of substrate for magnetic bubble |
JPH0233704B2 (ja) | 1982-10-07 | 1990-07-30 | Takeda Chemical Industries Ltd | Chikanbinirukarubonsanjudotai |
FR2599737B1 (fr) | 1986-06-10 | 1989-05-19 | Sanofi Sa | Procede pour la fixation de groupes alkyles, alkenyles, cycloalkyles ou aralkyles sur une chaine carbonee portant un groupement fonctionnel |
JPH01135740A (ja) | 1987-11-24 | 1989-05-29 | Nippon Mining Co Ltd | 光学活性を有する2―アルキル―1―アルカン酸の製造方法 |
US5021398A (en) | 1989-10-26 | 1991-06-04 | Amp Incorporated | Method of forming patterned oxide superconducting films |
US5102913A (en) * | 1991-07-01 | 1992-04-07 | Halikas James A | Treatment for cocaine use employing valproic acid |
DE4231085A1 (de) * | 1992-09-12 | 1994-03-17 | Desitin Arzneimittel Gmbh | VPA-analoge Antiepileptika |
JPH08501314A (ja) | 1992-09-16 | 1996-02-13 | ジェネンテク,インコーポレイテッド | Hgfによる肝臓障害に対する保護 |
JPH08503732A (ja) | 1992-11-30 | 1996-04-23 | ザ、プロクター、エンド、ギャンブル、カンパニー | 特選の石鹸を含有する高起泡性洗剤組成物 |
JP3304459B2 (ja) | 1992-12-18 | 2002-07-22 | 松下電器産業株式会社 | 電解コンデンサ駆動用電解液およびそれを用いた電解コンデンサ |
DK0632008T3 (da) | 1993-06-01 | 1998-09-23 | Ono Pharmaceutical Co | Pentansyrederivater |
US5503830A (en) | 1993-09-10 | 1996-04-02 | Petrovax, L.L.C. | Compounds having immunostimulating activity and methods of use thereof |
WO1995033044A1 (fr) | 1994-05-27 | 1995-12-07 | The Procter & Gamble Company | Compositions detergentes de blanchissage liquides comprenant des savons selectionnes specialement |
US5681854A (en) | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
IT1283489B1 (it) | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
-
1999
- 1999-06-22 KR KR1020007014630A patent/KR20010071572A/ko not_active Application Discontinuation
- 1999-06-22 EP EP99930555A patent/EP1089725A1/fr not_active Withdrawn
- 1999-06-22 CA CA002335641A patent/CA2335641A1/fr not_active Abandoned
- 1999-06-22 US US09/337,986 patent/US6268396B1/en not_active Expired - Fee Related
- 1999-06-22 HU HU0102456A patent/HUP0102456A3/hu unknown
- 1999-06-22 WO PCT/US1999/014081 patent/WO1999066920A1/fr not_active Application Discontinuation
- 1999-06-22 PL PL99345364A patent/PL345364A1/xx not_active Application Discontinuation
- 1999-06-22 BR BR9911421-6A patent/BR9911421A/pt not_active IP Right Cessation
- 1999-06-22 SK SK1999-2000A patent/SK19992000A3/sk unknown
- 1999-06-22 TR TR2000/03800T patent/TR200003800T2/xx unknown
- 1999-06-22 JP JP2000555606A patent/JP2002518442A/ja active Pending
- 1999-06-22 CN CN99808955A patent/CN1310622A/zh active Pending
- 1999-06-22 CZ CZ20004833A patent/CZ20004833A3/cs unknown
- 1999-06-22 IL IL14041599A patent/IL140415A0/xx unknown
- 1999-06-22 MX MXPA00012808A patent/MXPA00012808A/es unknown
- 1999-06-22 AU AU47071/99A patent/AU752192B2/en not_active Ceased
- 1999-06-27 TR TR2001/03249T patent/TR200103249T2/xx unknown
- 1999-06-28 AU AU52071/99A patent/AU5207199A/en not_active Abandoned
-
2000
- 2000-12-19 ZA ZA200007652A patent/ZA200007652B/en unknown
- 2000-12-20 NO NO20006506A patent/NO20006506L/no not_active Application Discontinuation
-
2001
- 2001-01-17 BG BG105163A patent/BG63744B1/bg unknown
- 2001-04-23 US US09/840,376 patent/US6458840B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUP0102456A3 (en) | 2003-07-28 |
IL140415A0 (en) | 2002-02-10 |
TR200103249T2 (tr) | 2002-05-21 |
US6458840B2 (en) | 2002-10-01 |
BR9911421A (pt) | 2001-03-27 |
US20010031789A1 (en) | 2001-10-18 |
AU752192B2 (en) | 2002-09-12 |
BG63744B1 (bg) | 2002-11-29 |
TR200003800T2 (tr) | 2001-06-21 |
MXPA00012808A (es) | 2002-04-24 |
NO20006506D0 (no) | 2000-12-20 |
SK19992000A3 (sk) | 2001-08-06 |
EP1089725A1 (fr) | 2001-04-11 |
ZA200007652B (en) | 2002-03-19 |
NO20006506L (no) | 2001-02-21 |
HUP0102456A2 (hu) | 2001-10-28 |
US6268396B1 (en) | 2001-07-31 |
WO1999066920A1 (fr) | 1999-12-29 |
BG105163A (en) | 2002-03-29 |
AU5207199A (en) | 2000-01-24 |
PL345364A1 (en) | 2001-12-17 |
AU4707199A (en) | 2000-01-10 |
JP2002518442A (ja) | 2002-06-25 |
CZ20004833A3 (cs) | 2002-01-16 |
CN1310622A (zh) | 2001-08-29 |
CA2335641A1 (fr) | 1999-12-29 |
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