ZA200007652B - The use of valproic acid analog for the treatment and prevention of migraine and affective illness. - Google Patents
The use of valproic acid analog for the treatment and prevention of migraine and affective illness. Download PDFInfo
- Publication number
- ZA200007652B ZA200007652B ZA200007652A ZA200007652A ZA200007652B ZA 200007652 B ZA200007652 B ZA 200007652B ZA 200007652 A ZA200007652 A ZA 200007652A ZA 200007652 A ZA200007652 A ZA 200007652A ZA 200007652 B ZA200007652 B ZA 200007652B
- Authority
- ZA
- South Africa
- Prior art keywords
- propyl
- hexynoic acid
- treatment
- substance
- composition
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title claims description 42
- 206010027599 migraine Diseases 0.000 title claims description 37
- 230000002265 prevention Effects 0.000 title claims description 23
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical class CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title description 17
- 238000000034 method Methods 0.000 claims description 49
- AAFSOWLNAOPEQF-UHFFFAOYSA-N 2-propylhex-4-ynoic acid Chemical compound CCCC(C(O)=O)CC#CC AAFSOWLNAOPEQF-UHFFFAOYSA-N 0.000 claims description 47
- 150000001875 compounds Chemical class 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 28
- 239000000126 substance Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 13
- 206010026749 Mania Diseases 0.000 claims description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000001154 acute effect Effects 0.000 claims description 4
- AAFSOWLNAOPEQF-MRVPVSSYSA-N (2r)-2-propylhex-4-ynoic acid Chemical compound CCC[C@@H](C(O)=O)CC#CC AAFSOWLNAOPEQF-MRVPVSSYSA-N 0.000 claims 6
- AAFSOWLNAOPEQF-QMMMGPOBSA-N (2s)-2-propylhex-4-ynoic acid Chemical compound CCC[C@H](C(O)=O)CC#CC AAFSOWLNAOPEQF-QMMMGPOBSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 description 51
- 239000003814 drug Substances 0.000 description 35
- 229940079593 drug Drugs 0.000 description 34
- 230000000694 effects Effects 0.000 description 25
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical class [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 22
- 241000700159 Rattus Species 0.000 description 20
- 230000001535 kindling effect Effects 0.000 description 18
- 210000004727 amygdala Anatomy 0.000 description 17
- 229960000604 valproic acid Drugs 0.000 description 16
- 230000002829 reductive effect Effects 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 11
- 206010003591 Ataxia Diseases 0.000 description 10
- 230000002411 adverse Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 239000003981 vehicle Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 230000000638 stimulation Effects 0.000 description 9
- 230000036760 body temperature Effects 0.000 description 8
- 206010015037 epilepsy Diseases 0.000 description 8
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 239000001961 anticonvulsive agent Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 6
- 229940102566 valproate Drugs 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 238000010825 rotarod performance test Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 206010009346 Clonus Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000003556 anti-epileptic effect Effects 0.000 description 4
- 229960003965 antiepileptics Drugs 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000036515 potency Effects 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000003390 teratogenic effect Effects 0.000 description 4
- 208000033001 Complex partial seizures Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 208000000060 Migraine with aura Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000001407 Vascular Headaches Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 230000002460 anti-migrenic effect Effects 0.000 description 3
- 230000003542 behavioural effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 230000002197 limbic effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 206010052787 migraine without aura Diseases 0.000 description 3
- 230000007971 neurological deficit Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 231100000378 teratogenic Toxicity 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- VCCNKWWXYVWTLT-CYZBKYQRSA-N 7-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 VCCNKWWXYVWTLT-CYZBKYQRSA-N 0.000 description 2
- 241000220479 Acacia Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000001773 anti-convulsant effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229960000623 carbamazepine Drugs 0.000 description 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 2
- 229960003529 diazepam Drugs 0.000 description 2
- 230000010339 dilation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229960001903 ergotamine tartrate Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 210000003194 forelimb Anatomy 0.000 description 2
- 230000025561 forward locomotion Effects 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 208000018883 loss of balance Diseases 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000036640 muscle relaxation Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 230000001314 paroxysmal effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- VWPXMGURRCAAAR-UHFFFAOYSA-N 2-propylhex-3-ynoic acid Chemical compound CCCC(C(O)=O)C#CCC VWPXMGURRCAAAR-UHFFFAOYSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 101100479039 Caenorhabditis elegans aars-1 gene Proteins 0.000 description 1
- 241000725101 Clea Species 0.000 description 1
- 206010053398 Clonic convulsion Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241001658031 Eris Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010073306 Exposure to radiation Diseases 0.000 description 1
- 206010016777 Flight of ideas Diseases 0.000 description 1
- 102000005915 GABA Receptors Human genes 0.000 description 1
- 108010005551 GABA Receptors Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010018671 Grandiosity Diseases 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 206010020400 Hostility Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010027603 Migraine headaches Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010061334 Partial seizures Diseases 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 206010054956 Phonophobia Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 206010035039 Piloerection Diseases 0.000 description 1
- 206010036649 Pressure of speech Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 206010043275 Teratogenicity Diseases 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000573 anti-seizure effect Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000005978 brain dysfunction Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940075960 desitin Drugs 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229960004943 ergotamine Drugs 0.000 description 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 230000004399 eye closure Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 230000035863 hyperlocomotion Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 235000011160 magnesium carbonates Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000010034 metabolic health Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 229960005152 pentetrazol Drugs 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 230000005371 pilomotor reflex Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- LSEKLPKUWRDLKY-UHFFFAOYSA-N protoleucomelone Chemical compound C1=CC(OC(=O)C)=CC=C1C1=C(OC(C)=O)C(OC(C)=O)=C(C=2C(=CC(OC(C)=O)=C(OC(C)=O)C=2)O2)C2=C1OC(C)=O LSEKLPKUWRDLKY-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 235000008001 rakum palm Nutrition 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000028527 righting reflex Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000000891 standard diet Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 231100000211 teratogenicity Toxicity 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000003135 vibrissae Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9028198P | 1998-06-22 | 1998-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007652B true ZA200007652B (en) | 2002-03-19 |
Family
ID=22222101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007652A ZA200007652B (en) | 1998-06-22 | 2000-12-19 | The use of valproic acid analog for the treatment and prevention of migraine and affective illness. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6268396B1 (fr) |
| EP (1) | EP1089725A1 (fr) |
| JP (1) | JP2002518442A (fr) |
| KR (1) | KR20010071572A (fr) |
| CN (1) | CN1310622A (fr) |
| AU (2) | AU752192B2 (fr) |
| BG (1) | BG63744B1 (fr) |
| BR (1) | BR9911421A (fr) |
| CA (1) | CA2335641A1 (fr) |
| CZ (1) | CZ20004833A3 (fr) |
| HU (1) | HUP0102456A3 (fr) |
| IL (1) | IL140415A0 (fr) |
| MX (1) | MXPA00012808A (fr) |
| NO (1) | NO20006506L (fr) |
| PL (1) | PL345364A1 (fr) |
| SK (1) | SK19992000A3 (fr) |
| TR (2) | TR200003800T2 (fr) |
| WO (1) | WO1999066920A1 (fr) |
| ZA (1) | ZA200007652B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6104802A (en) | 1997-02-10 | 2000-08-15 | Genesys Telecommunications Laboratories, Inc. | In-band signaling for routing |
| EP1181012B1 (fr) | 1999-05-04 | 2004-09-15 | Keith R. Edwards | Valproate administre par voie intraveineuse dans les soins actifs des migraines |
| CZ2004266A3 (cs) | 2000-07-21 | 2005-02-16 | Teva Pharmaceutical Industries, Ltd. | Použití derivátů amidů kyseliny valproové a kyseliny 2-valproenové pro léčbu mánie při bipolární poruše |
| AU8830801A (en) * | 2000-08-17 | 2002-02-25 | Teva Pharma | Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders |
| US20020103110A1 (en) * | 2001-01-26 | 2002-08-01 | Spitzer A. Robert | System and method for rectal administration of medication for treatment of migraines |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| WO2004050084A2 (fr) * | 2002-11-29 | 2004-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Inhibiteurs d'enzyme de conversion de l'angiotensine possedant une activite antioxydante et de donneur d'oxyde nitrique (no) |
| WO2004054957A2 (fr) * | 2002-12-16 | 2004-07-01 | The University Of British Columbia | Analogues de l'acide valproique et compositions pharmaceutiques les contenant |
| EP1543831A1 (fr) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Composition de pregabaline |
| WO2006012603A2 (fr) * | 2004-07-22 | 2006-02-02 | Nps Pharmaceuticals, Inc. | Analogues de l'isovaleramide, composition pharmaceutique contenant ces analogues et methode permettant de traiter des maladies ou des affections du systeme nerveux central |
| EP1928807A4 (fr) * | 2005-09-02 | 2011-05-04 | Picobella Llc | Arn regulateurs oncogenes pour le diagnostic et la therapie |
| US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
| US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
| AU2013257710B2 (en) * | 2012-05-08 | 2016-10-20 | Cellixbio Private Limited | Compositions and methods for the treatment of neurological disorders |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2442M (fr) | 1962-10-17 | 1964-04-06 | Henry Eugene | L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central. |
| US3701729A (en) | 1970-06-01 | 1972-10-31 | Tenneco Chem | Oil-soluble mixed copper soap products |
| US3847956A (en) | 1973-04-06 | 1974-11-12 | Us Agriculture | 2-hydroperoxycarboxylic acids and their preparation |
| US3932285A (en) | 1973-10-03 | 1976-01-13 | Tenneco Chemicals, Inc. | Chromium salt compositions and a process for their production |
| US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
| US4129599A (en) | 1975-04-28 | 1978-12-12 | The Board Of Trustees Of Leland Stanford Jr. University | A-Norsteroids |
| JPS5680116A (en) | 1979-12-05 | 1981-07-01 | Sanyo Electric Co Ltd | Manufacture of substrate for magnetic bubble |
| JPH0233704B2 (ja) | 1982-10-07 | 1990-07-30 | Takeda Chemical Industries Ltd | Chikanbinirukarubonsanjudotai |
| FR2599737B1 (fr) | 1986-06-10 | 1989-05-19 | Sanofi Sa | Procede pour la fixation de groupes alkyles, alkenyles, cycloalkyles ou aralkyles sur une chaine carbonee portant un groupement fonctionnel |
| JPH01135740A (ja) | 1987-11-24 | 1989-05-29 | Nippon Mining Co Ltd | 光学活性を有する２―アルキル―１―アルカン酸の製造方法 |
| US5021398A (en) | 1989-10-26 | 1991-06-04 | Amp Incorporated | Method of forming patterned oxide superconducting films |
| US5102913A (en) * | 1991-07-01 | 1992-04-07 | Halikas James A | Treatment for cocaine use employing valproic acid |
| DE4231085A1 (de) | 1992-09-12 | 1994-03-17 | Desitin Arzneimittel Gmbh | VPA-analoge Antiepileptika |
| JPH08501314A (ja) | 1992-09-16 | 1996-02-13 | ジェネンテク，インコーポレイテッド | Ｈｇｆによる肝臓障害に対する保護 |
| WO1994012608A1 (fr) | 1992-11-30 | 1994-06-09 | The Procter & Gamble Company | Compositions detergentes au pouvoir moussant eleve contenant des savons specialement selectionnes |
| JP3304459B2 (ja) | 1992-12-18 | 2002-07-22 | 松下電器産業株式会社 | 電解コンデンサ駆動用電解液およびそれを用いた電解コンデンサ |
| TW248552B (fr) | 1993-06-01 | 1995-06-01 | Onoda Yakuhin Kogyo Kk | |
| US5503830A (en) | 1993-09-10 | 1996-04-02 | Petrovax, L.L.C. | Compounds having immunostimulating activity and methods of use thereof |
| WO1995033044A1 (fr) | 1994-05-27 | 1995-12-07 | The Procter & Gamble Company | Compositions detergentes de blanchissage liquides comprenant des savons selectionnes specialement |
| US5681854A (en) | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
| IT1283489B1 (it) | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
-
1999
- 1999-06-22 TR TR2000/03800T patent/TR200003800T2/xx unknown
- 1999-06-22 HU HU0102456A patent/HUP0102456A3/hu unknown
- 1999-06-22 CA CA002335641A patent/CA2335641A1/fr not_active Abandoned
- 1999-06-22 SK SK1999-2000A patent/SK19992000A3/sk unknown
- 1999-06-22 PL PL99345364A patent/PL345364A1/xx not_active Application Discontinuation
- 1999-06-22 CZ CZ20004833A patent/CZ20004833A3/cs unknown
- 1999-06-22 CN CN99808955A patent/CN1310622A/zh active Pending
- 1999-06-22 IL IL14041599A patent/IL140415A0/xx unknown
- 1999-06-22 AU AU47071/99A patent/AU752192B2/en not_active Ceased
- 1999-06-22 US US09/337,986 patent/US6268396B1/en not_active Expired - Fee Related
- 1999-06-22 MX MXPA00012808A patent/MXPA00012808A/es unknown
- 1999-06-22 BR BR9911421-6A patent/BR9911421A/pt not_active IP Right Cessation
- 1999-06-22 KR KR1020007014630A patent/KR20010071572A/ko not_active Application Discontinuation
- 1999-06-22 JP JP2000555606A patent/JP2002518442A/ja active Pending
- 1999-06-22 WO PCT/US1999/014081 patent/WO1999066920A1/fr not_active Application Discontinuation
- 1999-06-22 EP EP99930555A patent/EP1089725A1/fr not_active Withdrawn
- 1999-06-27 TR TR2001/03249T patent/TR200103249T2/xx unknown
- 1999-06-28 AU AU52071/99A patent/AU5207199A/en not_active Abandoned
-
2000
- 2000-12-19 ZA ZA200007652A patent/ZA200007652B/en unknown
- 2000-12-20 NO NO20006506A patent/NO20006506L/no not_active Application Discontinuation
-
2001
- 2001-01-17 BG BG105163A patent/BG63744B1/bg unknown
- 2001-04-23 US US09/840,376 patent/US6458840B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL345364A1 (en) | 2001-12-17 |
| WO1999066920A1 (fr) | 1999-12-29 |
| CA2335641A1 (fr) | 1999-12-29 |
| HUP0102456A3 (en) | 2003-07-28 |
| IL140415A0 (en) | 2002-02-10 |
| CN1310622A (zh) | 2001-08-29 |
| HUP0102456A2 (hu) | 2001-10-28 |
| MXPA00012808A (es) | 2002-04-24 |
| BG63744B1 (bg) | 2002-11-29 |
| US20010031789A1 (en) | 2001-10-18 |
| BG105163A (en) | 2002-03-29 |
| US6268396B1 (en) | 2001-07-31 |
| AU5207199A (en) | 2000-01-24 |
| JP2002518442A (ja) | 2002-06-25 |
| SK19992000A3 (sk) | 2001-08-06 |
| AU752192B2 (en) | 2002-09-12 |
| KR20010071572A (ko) | 2001-07-28 |
| NO20006506L (no) | 2001-02-21 |
| BR9911421A (pt) | 2001-03-27 |
| EP1089725A1 (fr) | 2001-04-11 |
| CZ20004833A3 (cs) | 2002-01-16 |
| TR200003800T2 (tr) | 2001-06-21 |
| AU4707199A (en) | 2000-01-10 |
| NO20006506D0 (no) | 2000-12-20 |
| US6458840B2 (en) | 2002-10-01 |
| TR200103249T2 (tr) | 2002-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200007652B (en) | The use of valproic acid analog for the treatment and prevention of migraine and affective illness. | |
| EP2035029B1 (fr) | Composés peptidiques destinés au traitement de l'état de mal épileptique réfractaire | |
| KR100758609B1 (ko) | 트라마돌 화합물 및 항경련 약물을 포함하는 조성물 | |
| TWI397417B (zh) | 具有協同抗驚厥功效之醫藥組成物 | |
| US9682069B2 (en) | Methods of treating Dravet syndrome | |
| US20060166976A1 (en) | Compositions and methods for treating or preventing convulsions or seizures | |
| JP2003515564A (ja) | Ｃｎｓ疾患の治療のためのピロリジンアセトアミド誘導体単体又は組み合わせ物 | |
| WO1997015300A2 (fr) | Utilisation de 4-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene pour la prophylaxie et le traitement des sequelles d'une insuffisance de vascularisation cerebrale aigüe et chronique et de maladies neurodegeneratives | |
| KR20070009746A (ko) | 통증의 치료에 사용하기 위한 알파-2-델타 리간드와ｐｄｅｖ 억제제의 상승작용 조합물 | |
| JP2017505786A (ja) | 神経障害の処置のためのバクロフェン、アカンプロセート、及び中鎖トリグリセライドの併用 | |
| JPH09501664A (ja) | 神経変性疾病におけるフルピルチンの一次及び二次神経保護作用 | |
| JP2004533415A (ja) | 双極性障害の予防もしくは治療における使用のためのカルバメート化合物 | |
| MX2007004491A (es) | Compuestos de carbamato para utilizar en el tratamiento de padecimientos neurodegenerativos. | |
| KR100922703B1 (ko) | [[2-(아미노-3,4-디옥소-1-사이클로부텐-1-일)아미노]알킬]-산 유도체를 포함하는 통증 치료용 약제학적 조성물 | |
| PL199587B1 (pl) | Związek 1-cykliczny aminoalkilocykloheksanowy, sposób jego wytwarzania, kompozycja farmaceutyczna i zastosowanie związku 1-cyklicznego aminoalkilocykloheksanowego | |
| MXPA05010763A (es) | Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo. | |
| US20200181067A1 (en) | Fluorinated amide derivatives and their uses as therapeutic agents | |
| CA2640402C (fr) | Ligands alpha-2-delta pour sommeil non reparateur | |
| CN114008013A (zh) | 伴有睡眠障碍的cns病症的治疗 | |
| CN117479931A (zh) | 用于治疗孤独症谱系障碍(asd)的方法 | |
| JP2022510363A (ja) | （ｒ）－２－（２－オキソピロリジン－１－イル）ブタンアミドと（ｓ）－２－（２－オキソピロリジン－１－イル）ブタンアミドを非ラセミ比で含む相乗的組成物 | |
| CN114096314A (zh) | 痴呆症的治疗和预防药 | |
| EA041317B1 (ru) | Синергетические композиции, содержащие (r)-димирацетам (1) и (s)-димирацетам (2) в нерацемическом соотношении | |
| MXPA02005071A (es) | Composiciones y metodos para el tratamiento o prevencion de convulsiones o ataques |