KR102928687B1 - 톨-유사 수용체 조절제 화합물의 제조 방법 - Google Patents
톨-유사 수용체 조절제 화합물의 제조 방법Info
- Publication number
- KR102928687B1 KR102928687B1 KR1020247017239A KR20247017239A KR102928687B1 KR 102928687 B1 KR102928687 B1 KR 102928687B1 KR 1020247017239 A KR1020247017239 A KR 1020247017239A KR 20247017239 A KR20247017239 A KR 20247017239A KR 102928687 B1 KR102928687 B1 KR 102928687B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- salt
- solvent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962868662P | 2019-06-28 | 2019-06-28 | |
| US62/868,662 | 2019-06-28 | ||
| KR1020227002741A KR102670017B1 (ko) | 2019-06-28 | 2020-06-25 | 톨-유사 수용체 조절제 화합물의 제조 방법 |
| PCT/US2020/039501 WO2020264081A1 (en) | 2019-06-28 | 2020-06-25 | Processes for preparing toll-like receptor modulator compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227002741A Division KR102670017B1 (ko) | 2019-06-28 | 2020-06-25 | 톨-유사 수용체 조절제 화합물의 제조 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20240090883A KR20240090883A (ko) | 2024-06-21 |
| KR102928687B1 true KR102928687B1 (ko) | 2026-02-20 |
Family
ID=71608089
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247017239A Active KR102928687B1 (ko) | 2019-06-28 | 2020-06-25 | 톨-유사 수용체 조절제 화합물의 제조 방법 |
| KR1020227002741A Active KR102670017B1 (ko) | 2019-06-28 | 2020-06-25 | 톨-유사 수용체 조절제 화합물의 제조 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227002741A Active KR102670017B1 (ko) | 2019-06-28 | 2020-06-25 | 톨-유사 수용체 조절제 화합물의 제조 방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11286257B2 (https=) |
| EP (1) | EP3990455A1 (https=) |
| JP (2) | JP7246526B2 (https=) |
| KR (2) | KR102928687B1 (https=) |
| CN (2) | CN114269744B (https=) |
| AU (2) | AU2020304069C1 (https=) |
| CA (2) | CA3248411A1 (https=) |
| TW (1) | TWI879779B (https=) |
| WO (1) | WO2020264081A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US9670205B2 (en) | 2015-03-04 | 2017-06-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN114031615B (zh) * | 2021-11-19 | 2023-09-19 | 中国科学院上海有机化学研究所 | 羟基取代的吡啶噁唑啉配体及其在烯烃的氢卤化反应中的应用 |
| WO2023213445A1 (de) * | 2022-05-04 | 2023-11-09 | Heraeus Deutschland GmbH & Co. KG | Verfahren zur herstellung von 4-[5-[bis(2-chlorethyl)amino]-1-methyl-1h-benzo[d]imidazol-2-yl]butansäurealkylestern und formylierten derivaten |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016141092A1 (en) | 2015-03-04 | 2016-09-09 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
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| US12590089B2 (en) | 2026-03-31 |
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| JP7246526B2 (ja) | 2023-03-27 |
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| WO2020264081A1 (en) | 2020-12-30 |
| KR102670017B1 (ko) | 2024-05-29 |
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| AU2020304069B2 (en) | 2023-12-21 |
| CN114269744A (zh) | 2022-04-01 |
| CN119371422A (zh) | 2025-01-28 |
| US11286257B2 (en) | 2022-03-29 |
| KR20240090883A (ko) | 2024-06-21 |
| JP7626788B2 (ja) | 2025-02-04 |
| AU2020304069A1 (en) | 2022-02-17 |
| US20210017170A1 (en) | 2021-01-21 |
| US20220274985A1 (en) | 2022-09-01 |
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