AU2020304069C1 - Processes for preparing Toll-like receptor modulator compounds - Google Patents

Processes for preparing Toll-like receptor modulator compounds Download PDF

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Publication number
AU2020304069C1
AU2020304069C1 AU2020304069A AU2020304069A AU2020304069C1 AU 2020304069 C1 AU2020304069 C1 AU 2020304069C1 AU 2020304069 A AU2020304069 A AU 2020304069A AU 2020304069 A AU2020304069 A AU 2020304069A AU 2020304069 C1 AU2020304069 C1 AU 2020304069C1
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formula
compound
salt
solvent
reaction mixture
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AU2020304069B2 (en
AU2020304069A1 (en
Inventor
Evangelos Aktoudianakis
Andrea Ambrosi
Sylvie M. ASSELIN
Florence J. BACHRACH
Pavel R. Badalov
Gregory F. CHIN
Stephen P. LATHROP
Willard Lew
Richard L. Mackman
Jeffrey E. Merit
Samuel E. Metobo
Michael R. Mish
Beau P. Pritchett
Hyung-Jung Pyun
Christopher S. REGENS
Tiago VIEIRA
Xianghong Wang
Adam B. WEINSTEIN
Todd A. WENDERSKI
Zehua ZHENG
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Gilead Sciences Inc
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Gilead Sciences Inc
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Publication of AU2020304069B2 publication Critical patent/AU2020304069B2/en
Priority to AU2024201832A priority Critical patent/AU2024201832A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2020304069A 2019-06-28 2020-06-25 Processes for preparing Toll-like receptor modulator compounds Active AU2020304069C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024201832A AU2024201832A1 (en) 2019-06-28 2024-03-20 Processes for preparing Toll-like receptor modulator compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962868662P 2019-06-28 2019-06-28
US62/868,662 2019-06-28
PCT/US2020/039501 WO2020264081A1 (en) 2019-06-28 2020-06-25 Processes for preparing toll-like receptor modulator compounds

Related Child Applications (1)

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AU2024201832A Division AU2024201832A1 (en) 2019-06-28 2024-03-20 Processes for preparing Toll-like receptor modulator compounds

Publications (3)

Publication Number Publication Date
AU2020304069A1 AU2020304069A1 (en) 2022-02-17
AU2020304069B2 AU2020304069B2 (en) 2023-12-21
AU2020304069C1 true AU2020304069C1 (en) 2025-02-13

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AU2020304069A Active AU2020304069C1 (en) 2019-06-28 2020-06-25 Processes for preparing Toll-like receptor modulator compounds
AU2024201832A Pending AU2024201832A1 (en) 2019-06-28 2024-03-20 Processes for preparing Toll-like receptor modulator compounds

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Country Status (9)

Country Link
US (2) US11286257B2 (https=)
EP (1) EP3990455A1 (https=)
JP (2) JP7246526B2 (https=)
KR (2) KR102928687B1 (https=)
CN (2) CN114269744B (https=)
AU (2) AU2020304069C1 (https=)
CA (2) CA3248411A1 (https=)
TW (1) TWI879779B (https=)
WO (1) WO2020264081A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US9670205B2 (en) 2015-03-04 2017-06-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
AU2017318601B2 (en) 2016-09-02 2020-09-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN114031615B (zh) * 2021-11-19 2023-09-19 中国科学院上海有机化学研究所 羟基取代的吡啶噁唑啉配体及其在烯烃的氢卤化反应中的应用
WO2023213445A1 (de) * 2022-05-04 2023-11-09 Heraeus Deutschland GmbH & Co. KG Verfahren zur herstellung von 4-[5-[bis(2-chlorethyl)amino]-1-methyl-1h-benzo[d]imidazol-2-yl]butansäurealkylestern und formylierten derivaten

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016141092A1 (en) * 2015-03-04 2016-09-09 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds

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