KR102784294B1 - 타우 인식 항체 - Google Patents

타우 인식 항체 Download PDF

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KR102784294B1
KR102784294B1 KR1020197035549A KR20197035549A KR102784294B1 KR 102784294 B1 KR102784294 B1 KR 102784294B1 KR 1020197035549 A KR1020197035549 A KR 1020197035549A KR 20197035549 A KR20197035549 A KR 20197035549A KR 102784294 B1 KR102784294 B1 KR 102784294B1
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antibody
antibodies
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KR20200030029A (ko
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로빈 바버
스베틀라나 알렉산더
마크 이. 렌즈
슈닝 가이
필립 제임스 돌란
탈로칸 에스. 니자르
필립 페인
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프로테나 바이오사이언시즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Developing Agents For Electrophotography (AREA)
KR1020197035549A 2017-05-02 2018-05-02 타우 인식 항체 Active KR102784294B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762500427P 2017-05-02 2017-05-02
US62/500,427 2017-05-02
US201762580408P 2017-11-01 2017-11-01
US62/580,408 2017-11-01
PCT/US2018/030739 WO2018204546A2 (en) 2017-05-02 2018-05-02 Antibodies recognizing tau

Publications (2)

Publication Number Publication Date
KR20200030029A KR20200030029A (ko) 2020-03-19
KR102784294B1 true KR102784294B1 (ko) 2025-03-19

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ID=64016242

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197035549A Active KR102784294B1 (ko) 2017-05-02 2018-05-02 타우 인식 항체

Country Status (17)

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US (2) US11958896B2 (enExample)
EP (1) EP3619233A4 (enExample)
JP (2) JP7442790B2 (enExample)
KR (1) KR102784294B1 (enExample)
CN (1) CN110881274B (enExample)
AU (1) AU2018263935B2 (enExample)
BR (1) BR112019022906A2 (enExample)
CA (1) CA3061516A1 (enExample)
CO (1) CO2019013265A2 (enExample)
CU (1) CU24636B1 (enExample)
IL (1) IL270375B2 (enExample)
MX (1) MX2019013045A (enExample)
MY (1) MY206891A (enExample)
PE (1) PE20200695A1 (enExample)
SG (1) SG11201910066QA (enExample)
WO (1) WO2018204546A2 (enExample)
ZA (1) ZA201907819B (enExample)

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US10906964B2 (en) 2016-05-02 2021-02-02 Prothena Biosciences Limited Antibodies recognizing tau
SG11201808434WA (en) 2016-05-02 2018-10-30 Prothena Biosciences Ltd Antibodies recognizing tau
MA47499A (fr) 2017-02-17 2019-12-25 Denali Therapeutics Inc Anticorps anti-tau et leurs procédés d'utilisation
CN110881274B (zh) * 2017-05-02 2024-11-15 普罗塞纳生物科学有限公司 识别tau的抗体
US11660315B2 (en) 2017-09-28 2023-05-30 Immpact-Bio Ltd. Universal platform for preparing an inhibitory chimeric antigen receptor (iCAR)
WO2019077500A1 (en) * 2017-10-16 2019-04-25 Eisai R&D Management Co., Ltd. ANTI-WATER ANTIBODIES AND USES THEREOF
CA3131531A1 (en) * 2019-03-03 2020-09-10 Prothena Biosciences Limited Antibodies recognizing tau
PE20212266A1 (es) * 2019-03-26 2021-11-30 Janssen Pharmaceutica Nv ANTICUERPOS CONTRA AMILOIDE-ß CON PIROGLUTAMATO Y USOS DE ESTOS
AU2021276401A1 (en) 2020-05-19 2022-12-15 Othair Prothena Limited Multi-epitope vaccine for the treatment of Alzheimer's disease
EP4192497A4 (en) 2020-08-07 2024-08-21 Othair Prothena Limited MULTI-EPITOPIC VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
WO2022051727A2 (en) * 2020-09-04 2022-03-10 Immpact-Bio Ltd. BICISTRONIC INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR)/ACTIVATING CHIMERIC ANTIGEN RECEPTOR (aCAR) CONSTRUCTS FOR USE IN CANCER THERAPIES
TW202246320A (zh) * 2021-02-14 2022-12-01 愛爾蘭商普羅帝納生物科學公司 使用識別ｔａｕ之抗體之方法
CN116047081B (zh) * 2023-01-10 2024-02-13 北京新源长青生物科技有限公司 检测Aβ40、Aβ42的试剂盒与方法

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