JP7442790B2 - タウ認識抗体 - Google Patents

タウ認識抗体 Download PDF

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Publication number
JP7442790B2
JP7442790B2 JP2019557462A JP2019557462A JP7442790B2 JP 7442790 B2 JP7442790 B2 JP 7442790B2 JP 2019557462 A JP2019557462 A JP 2019557462A JP 2019557462 A JP2019557462 A JP 2019557462A JP 7442790 B2 JP7442790 B2 JP 7442790B2
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seq
antibodies
antibody
chain variable
amino acid
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Japanese (ja)
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JP2020520231A5 (enExample
JP2020520231A (ja
Inventor
フィリップ ペイン，
ロビン バーバー，
スヴェトラナ アレクサンダー，
マーク イー． レンツ，
シュニング ガイ，
フィリップ ジェームズ ドラン，
タルロチャン， エス． ニジャール，
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Prothena Biosciences Ltd
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Neotope Biosciences Ltd
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Priority to JP2023093577A priority Critical patent/JP7587304B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
JP2019557462A 2017-05-02 2018-05-02 タウ認識抗体 Active JP7442790B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023093577A JP7587304B2 (ja) 2017-05-02 2023-06-07 タウ認識抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762500427P 2017-05-02 2017-05-02
US62/500,427 2017-05-02
US201762580408P 2017-11-01 2017-11-01
US62/580,408 2017-11-01
PCT/US2018/030739 WO2018204546A2 (en) 2017-05-02 2018-05-02 Antibodies recognizing tau

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023093577A Division JP7587304B2 (ja) 2017-05-02 2023-06-07 タウ認識抗体

Publications (3)

Publication Number Publication Date
JP2020520231A JP2020520231A (ja) 2020-07-09
JP2020520231A5 JP2020520231A5 (enExample) 2021-06-17
JP7442790B2 true JP7442790B2 (ja) 2024-03-05

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Family Applications (2)

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JP2019557462A Active JP7442790B2 (ja) 2017-05-02 2018-05-02 タウ認識抗体
JP2023093577A Active JP7587304B2 (ja) 2017-05-02 2023-06-07 タウ認識抗体

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Country Status (17)

Country Link
US (2) US11958896B2 (enExample)
EP (1) EP3619233A4 (enExample)
JP (2) JP7442790B2 (enExample)
KR (1) KR102784294B1 (enExample)
CN (1) CN110881274B (enExample)
AU (1) AU2018263935B2 (enExample)
BR (1) BR112019022906A2 (enExample)
CA (1) CA3061516A1 (enExample)
CO (1) CO2019013265A2 (enExample)
CU (1) CU24636B1 (enExample)
IL (1) IL270375B2 (enExample)
MX (1) MX2019013045A (enExample)
MY (1) MY206891A (enExample)
PE (1) PE20200695A1 (enExample)
SG (1) SG11201910066QA (enExample)
WO (1) WO2018204546A2 (enExample)
ZA (1) ZA201907819B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023113836A (ja) * 2017-05-02 2023-08-16 プロセナ バイオサイエンシーズ リミテッド タウ認識抗体

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US10906964B2 (en) 2016-05-02 2021-02-02 Prothena Biosciences Limited Antibodies recognizing tau
MX2018013384A (es) 2016-05-02 2019-02-28 Prothena Biosciences Ltd Anticuerpos que reconocen tau.
CA3053379A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
PL3688155T3 (pl) 2017-09-28 2023-09-11 Immpact-Bio Ltd. Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar)
JP6851549B2 (ja) 2017-10-16 2021-03-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗タウ抗体及びその使用
TWI859197B (zh) 2019-03-03 2024-10-21 愛爾蘭商普羅帝納生物科學公司 識別ｔａｕ之抗體
SG11202110504XA (en) * 2019-03-26 2021-10-28 Janssen Pharmaceutica Nv ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF
AU2021276401A1 (en) 2020-05-19 2022-12-15 Othair Prothena Limited Multi-epitope vaccine for the treatment of Alzheimer's disease
CN116472055A (zh) 2020-08-07 2023-07-21 欧萨尔普罗席纳有限公司 治疗阿尔兹海默氏病的多表位疫苗
IL300346A (en) * 2020-08-07 2023-04-01 Prothena Biosciences Ltd TAU vaccine for the treatment of Alzheimer's disease
EP4208176A4 (en) * 2020-09-04 2025-06-25 Gavish-Galilee Bio Applications Ltd. Constructs of the bicistronic inhibiting chimeric antigen receptor (ICAR)/activating chimeric antigen receptor (ACAR) for use in cancer therapies
AU2022219986A1 (en) * 2021-02-14 2023-08-31 Prothena Biosciences Limited Methods of using antibodies recognizing tau
CN116047081B (zh) * 2023-01-10 2024-02-13 北京新源长青生物科技有限公司 检测Aβ40、Aβ42的试剂盒与方法

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