KR102592242B1 - 유사가소성 마이크로겔 매트릭스용 조성물 및 키트 - Google Patents

유사가소성 마이크로겔 매트릭스용 조성물 및 키트 Download PDF

Info

Publication number
KR102592242B1
KR102592242B1 KR1020177032839A KR20177032839A KR102592242B1 KR 102592242 B1 KR102592242 B1 KR 102592242B1 KR 1020177032839 A KR1020177032839 A KR 1020177032839A KR 20177032839 A KR20177032839 A KR 20177032839A KR 102592242 B1 KR102592242 B1 KR 102592242B1
Authority
KR
South Korea
Prior art keywords
proteins
tissue
poly
agents
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020177032839A
Other languages
English (en)
Korean (ko)
Other versions
KR20170140274A (ko
Inventor
조셉 찰스 살라몬
앤 빌 살라몬
케서린 엘리자베스 레일리
라우라 진 석스
정은나
케리 쌰오유-첸 렁
케리 ?X오유-첸 렁
Original Assignee
로찰 테크놀로지스, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로찰 테크놀로지스, 엘엘씨 filed Critical 로찰 테크놀로지스, 엘엘씨
Publication of KR20170140274A publication Critical patent/KR20170140274A/ko
Application granted granted Critical
Publication of KR102592242B1 publication Critical patent/KR102592242B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers & Plastics (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020177032839A 2015-04-17 2016-04-12 유사가소성 마이크로겔 매트릭스용 조성물 및 키트 Active KR102592242B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/689,625 2015-04-17
US14/689,625 US20160303281A1 (en) 2015-04-17 2015-04-17 Composition and kits for pseudoplastic microgel matrices
PCT/US2016/027131 WO2016168196A1 (en) 2015-04-17 2016-04-12 Composition and kits for pseudoplastic microgel matrices

Publications (2)

Publication Number Publication Date
KR20170140274A KR20170140274A (ko) 2017-12-20
KR102592242B1 true KR102592242B1 (ko) 2023-10-25

Family

ID=57126813

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177032839A Active KR102592242B1 (ko) 2015-04-17 2016-04-12 유사가소성 마이크로겔 매트릭스용 조성물 및 키트

Country Status (13)

Country Link
US (2) US20160303281A1 (https=)
EP (1) EP3283057B1 (https=)
JP (1) JP6930733B2 (https=)
KR (1) KR102592242B1 (https=)
CN (1) CN107708675B (https=)
AU (1) AU2016250012B2 (https=)
BR (1) BR112017022045B1 (https=)
CA (1) CA2982352C (https=)
DK (1) DK3283057T3 (https=)
ES (1) ES2895947T3 (https=)
MX (1) MX386446B (https=)
PT (1) PT3283057T (https=)
WO (1) WO2016168196A1 (https=)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102264607B1 (ko) 2014-07-17 2021-06-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자
US12458731B2 (en) 2015-08-17 2025-11-04 The Johns Hopkins University Mesenchymal cell-binding composite material for tissue restoration
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
CN110446508A (zh) 2016-12-29 2019-11-12 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
IT201700087978A1 (it) 2017-07-31 2019-01-31 Univ Degli Studi Genova Scaffold di idrogel tridimensionale per colture cellulari e metodo per la sua produzione
KR102172222B1 (ko) * 2017-12-29 2020-10-30 서울대학교산학협력단 단백질 약물 전달용 광가교 마이크로젤 및 그의 제조 방법
US20200353127A1 (en) * 2018-01-10 2020-11-12 G2Gbio, Inc. Collagen peptide-containing polycaprolactone microsphere filler and preparation method therefor
US20190240335A1 (en) * 2018-02-07 2019-08-08 Promedon S.A. Biocompatible Hydrogel Compositions
CN110193094A (zh) * 2018-02-24 2019-09-03 上海优先生物医学工程有限公司 一种软组织填充修复材料及其制备方法和用途
KR102090576B1 (ko) * 2018-02-26 2020-03-18 주식회사 엔도비전 상처치료용 다층 드레싱재
US10335421B1 (en) 2018-02-26 2019-07-02 Aisha Chaudhry Topical wound care formulation
CN108653196A (zh) * 2018-04-11 2018-10-16 燕山大学 一种脂质体复合双响应载药水凝胶的制备方法
CN110402918A (zh) * 2018-04-27 2019-11-05 庄明华 一种保存骨组织材料的方法
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
CA3099732A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
CN108715833B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种负载血小板裂解液的微球制备方法
GB201810925D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and methods of treatment
CN109224123B (zh) * 2018-10-11 2021-04-09 成都迪康中科生物医学材料有限公司 具有抑制肿瘤作用的纳米羟基磷灰石复合材料及制备方法
CN109298180A (zh) * 2018-11-19 2019-02-01 中南大学 一种检测鼠伤寒沙门氏菌的方法
GB201820021D0 (en) * 2018-12-07 2019-01-23 Univ Birmingham Ocular hydrogel compositions
GB201820018D0 (en) * 2018-12-07 2019-01-23 Univ Birmingham Therapeutic hydrogel compositions
CN109481739B (zh) * 2018-12-12 2021-07-30 四川大学华西医院 一种骨关节润滑剂及其制备方法
US11832879B2 (en) * 2019-03-08 2023-12-05 Neuwave Medical, Inc. Systems and methods for energy delivery
US11065188B2 (en) 2019-05-29 2021-07-20 Av Laboratories Llc Applications and formulations of optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents
WO2020241791A1 (en) * 2019-05-31 2020-12-03 Sumitomo Chemical Company, Limited Liquid suspension concentrate formulation comprising mefentrifluconazole
CN110721344B (zh) * 2019-11-21 2020-12-11 北京帝康医药投资管理有限公司 一种用于促进心肌修复的可注射生物凝胶及其制备方法
CN110898250B (zh) * 2019-11-28 2020-11-13 浙江大学 一种用于皮肤移植的自降解水凝胶粘合剂材料及其制备方法
SG10202101181TA (en) * 2020-02-07 2021-09-29 Univ Nanyang Tech Biofunctional hydrogel for wound healing
WO2021174008A1 (en) * 2020-02-28 2021-09-02 University Of Florida Research Foundation Compositions, methods, kits, and systems relating to charge-neutral microgels for 3d cell culture and printing
EP4121131A1 (en) * 2020-03-20 2023-01-25 Bard Peripheral Vascular, Inc. Reactive hydrogel forming formulations and related methods
CN111840654B (zh) * 2020-08-04 2021-05-25 李双宏 一种改性透明质酸复合美容整形材料的制备方法
CN112370567B (zh) * 2020-11-19 2023-05-16 南方医科大学南方医院 一种具有抗菌消炎功能的水凝胶活性敷料
CN112708594B (zh) * 2021-01-26 2022-02-25 中科博生生物工程有限公司 脐带间充质干细胞复苏培养基及其制备方法和应用
CN113332499B (zh) * 2021-03-17 2022-06-28 上海玮沐医疗科技有限公司 一种自控温光热效应微球及其制备方法
EP4331566A4 (en) * 2021-03-22 2025-03-26 Sunbio Inc. Mouth rinse composition including polyethylene glycol derivative as active ingredient for alleviating xerostomia
CN113341146B (zh) * 2021-04-29 2023-06-13 重庆医科大学 用于检测乙肝病毒的比色传感器及其制备与应用
CN113368216A (zh) * 2021-05-28 2021-09-10 薛安全 一种干眼症治疗制剂及其制备方法
IT202100017396A1 (it) * 2021-07-01 2023-01-01 Azienda Unita Sanitaria Locale Della Romagna Metodica di conservazione a temperatura ambiente di tessuti e organi destinati all’uso clinico
EP4373535A4 (en) 2021-07-21 2025-05-14 Organogenesis Inc. Porcine collagen compositions and methods of use thereof
CN115814157B (zh) * 2021-09-16 2024-06-07 齐鲁工业大学 一种用于骨整合材料的抗菌性涂层及其制备方法
CN115501394B (zh) * 2021-11-18 2023-08-04 南京工业大学 一种颗粒凝胶复合支架及其制备方法和应用
US20250041488A1 (en) * 2021-12-09 2025-02-06 Likarda, LLC Hydrogel microparticle-based soft tissue fillers
JP2024544237A (ja) * 2021-12-20 2024-11-28 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド マイクロゲル、マイクロゲルの作製方法、及びマイクロゲルの使用方法
CN114276989A (zh) * 2021-12-31 2022-04-05 四川大学华西医院 递送脂肪干细胞的微凝胶及其制备方法
CN114711326B (zh) * 2021-12-31 2023-09-22 上海食未生物科技有限公司 一种基于悬浮3d打印的食品打印材料、其制备方法和在人造肉中的应用
CN114307963A (zh) * 2022-01-12 2022-04-12 杭州星宇炭素环保科技有限公司 一种基于废旧棉织品的改性活性炭纤维及应用
CN114404672B (zh) * 2022-01-19 2023-03-03 四川大学 一种联合多酚和抗菌肽的纤维膜及其制备方法和应用
CN115282339B (zh) * 2022-07-28 2023-02-28 四川大学 一种交联透明质酸/羟基磷灰石可注射材料、制备方法及应用
US20260042889A1 (en) * 2022-08-05 2026-02-12 University Of Washington Systems and methods for selective shape transformation of 3d-printed materials
CN115317665B (zh) * 2022-08-12 2023-08-18 济南格莱威医疗科技有限公司 一种聚酯粒子复合温敏即型凝胶皮下植入剂
KR102819248B1 (ko) * 2022-11-01 2025-06-11 순천향대학교 산학협력단 상처 치유능을 갖는 아가로스 기반 tocn-ecm 이중층 유착방지 하이드로겔
CN115748249B (zh) * 2022-11-23 2024-06-25 浙江诸暨聚源生物技术有限公司 重组胶原蛋白水凝胶纤维及其制备方法
CN115845121B (zh) * 2022-12-07 2024-08-02 华南理工大学 止血、抗菌、促愈合的微凝胶组装体粉末及其制备方法
CN115607740B (zh) * 2022-12-21 2023-04-21 北京德益达美医疗科技有限公司 一种生长因子复合肌腱及其制备方法
CN116270417B (zh) * 2023-01-10 2026-04-07 常州大学 核壳结构的载药纳米粒微针贴片及其制备方法和应用
WO2024159015A1 (en) * 2023-01-25 2024-08-02 North Carolina State University Compositions and methods relating to inhalable therapeutic compositions
WO2024217548A1 (en) * 2023-04-20 2024-10-24 The Chinese University Of Hong Kong Method for fabrication and modulation of extracellular matrix biomaterials
WO2024254082A1 (en) * 2023-06-05 2024-12-12 Rowan University Compositions and methods for cell culture applications
CN117018269A (zh) * 2023-08-15 2023-11-10 苏州大学 一种仿贻贝多功能丝素蛋白基粘合剂及其制备方法与应用
WO2025128639A1 (en) * 2023-12-12 2025-06-19 The Children's Medical Center Corporation Hydrogels comprising protein-stabilized nanoparticles for extended release
WO2025149946A1 (en) * 2024-01-10 2025-07-17 Biorchestra Co., Ltd. Micellar nanoparticles and uses thereof
WO2025170943A1 (en) * 2024-02-08 2025-08-14 Integral Biosystems Llc Methods and compositions to administer therapeutics to soft tissue surfaces
US20250319021A1 (en) * 2024-02-21 2025-10-16 Vitalte Lifesciences Inc. Composition of hydrogel loaded with hormone
WO2025212041A1 (en) * 2024-04-01 2025-10-09 National University Of Singapore Collapsible cell-encapsulating scaffolds to enhance magnetically-induced secretome stabilisation and potency
WO2026050478A1 (en) * 2024-08-28 2026-03-05 Rochal Technologies Llc Methods of treating cartilage with pseudoplastic hydrolyzed collagen-containing compositions
CN119708555B (zh) * 2025-02-28 2025-05-13 成都丁因生物科技有限公司 一种双重修饰的交联透明质酸凝胶制备方法及应用
CN120554666B (zh) * 2025-07-31 2025-11-25 清华大学 自组装微凝胶、微凝胶支架及其制备方法和制备装置
CN121059825B (zh) * 2025-11-10 2026-02-17 同济大学 一种表面修饰的抗血管生成的纳米组装体及其制备方法
CN121248971B (zh) * 2025-12-05 2026-02-24 广东海洋大学 一种海洋多糖基水凝胶及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001483A1 (en) 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
US20030045690A1 (en) 2001-08-30 2003-03-06 Gerard Marx Fibrin nanoparticles and uses thereof
US20140170224A1 (en) * 2012-12-14 2014-06-19 Agency For Science, Technology And Research Gelatin-based microgels

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128305C (https=) 1963-09-11
US4172066A (en) 1974-06-21 1979-10-23 The Dow Chemical Company Cross-linked, water-swellable polymer microgels
JPH0739508B2 (ja) * 1986-11-11 1995-05-01 株式会社林原生物化学研究所 プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
EP0637450A3 (en) * 1993-08-04 1995-04-05 Collagen Corp Method and composition for resuscitation of hereditary tissue.
ES2172573T3 (es) 1993-12-01 2002-10-01 Bioartificial Gel Technologies Inc Hidrogel basado en albumina.
AU682266B2 (en) 1994-04-04 1997-09-25 Collagen Corporation Cell-gels
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6150505A (en) 1997-09-19 2000-11-21 Hadasit Medical Research Services & Development Ltd. Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US7582311B1 (en) 1999-10-15 2009-09-01 Genentech, Inc. Injection vehicle for polymer-based formulations
US7651703B2 (en) * 1999-10-15 2010-01-26 Genentech, Inc. Injection vehicle for polymer-based formulations
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
AU2003228808A1 (en) 2002-05-02 2003-11-17 Regents Of The University Of Minnesota Fibrin-based biomatrix
WO2004066704A2 (en) 2003-01-17 2004-08-12 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
EP2060280A3 (en) 2003-04-30 2009-05-27 Drexel University Thermogelling polymer blends for biomaterial applications
EP2289567A3 (en) * 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
EP1750769B1 (en) 2004-05-20 2013-01-23 Mentor Worldwide LLC Methods for making injectable polymer hydrogels
EP1891941A1 (en) * 2006-08-11 2008-02-27 OctoPlus Technologies B.V. Aqueous gels comprising microspheres
JP5385257B2 (ja) 2007-03-26 2014-01-08 バクスター・インターナショナル・インコーポレイテッド 軟部組織増強のための注入可能な空隙の充填剤
US9624259B2 (en) * 2007-04-16 2017-04-18 Regentis Biomaterials Ltd. Compositions and methods for scaffold formation
US20080268056A1 (en) 2007-04-26 2008-10-30 Abhijeet Joshi Injectable copolymer hydrogel useful for repairing vertebral compression fractures
US20110077737A1 (en) 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
WO2009042514A1 (en) 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
WO2009079555A2 (en) 2007-12-17 2009-06-25 Anna Love Soft tissue filler
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
JP5574083B2 (ja) 2008-08-01 2014-08-20 アンタイス エス．エイ． 高い残留性及び容量を与える高い能力を有する注入可能なヒドロゲル
US8557288B2 (en) 2008-08-15 2013-10-15 Washington University Hydrogel microparticle formation in aqueous solvent for biomedical applications
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
IL195764A0 (en) 2008-12-07 2009-11-18 Technion Res & Dev Foundation Compositions and methods for drug delivery
WO2011005381A2 (en) * 2009-06-01 2011-01-13 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
EP2512516B1 (en) 2009-12-18 2016-02-17 The Governing Council Of The University Of Toronto Injectable polymer composition for use as a cell delivery vehicle
WO2012002986A2 (en) 2009-12-21 2012-01-05 The Regents Of The University Of California Decellularized and delipidized extracellular matrix and methods of use
US20150037422A1 (en) * 2012-02-22 2015-02-05 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
DK2953659T3 (da) 2013-02-08 2019-11-25 Acell Inc Fremgangsmåder til at fremstille bioaktive geler fra extracellulært matrixmateriale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001483A1 (en) 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
US20030045690A1 (en) 2001-08-30 2003-03-06 Gerard Marx Fibrin nanoparticles and uses thereof
US20140170224A1 (en) * 2012-12-14 2014-06-19 Agency For Science, Technology And Research Gelatin-based microgels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Murat Guvendiren et al., "Shear-thinning hydrogels for biomedical applications." Soft Matter (2012), Vol.8, pp. 260-272*

Also Published As

Publication number Publication date
MX386446B (es) 2025-03-18
CN107708675A (zh) 2018-02-16
JP6930733B2 (ja) 2021-09-01
CN107708675B (zh) 2022-07-22
DK3283057T3 (da) 2021-11-01
HK1245663A1 (zh) 2018-08-31
WO2016168196A1 (en) 2016-10-20
EP3283057B1 (en) 2021-07-28
PT3283057T (pt) 2021-11-04
CA2982352A1 (en) 2016-10-20
CA2982352C (en) 2025-05-06
US20160303281A1 (en) 2016-10-20
KR20170140274A (ko) 2017-12-20
US11590259B2 (en) 2023-02-28
BR112017022045B1 (pt) 2023-11-28
US20210308323A1 (en) 2021-10-07
AU2016250012B2 (en) 2020-12-03
BR112017022045A2 (pt) 2018-07-03
EP3283057A1 (en) 2018-02-21
NZ736266A (en) 2024-05-31
JP2018511622A (ja) 2018-04-26
ES2895947T3 (es) 2022-02-23
AU2016250012A1 (en) 2017-11-02
MX2017013002A (es) 2018-02-01
EP3283057A4 (en) 2018-12-12

Similar Documents

Publication Publication Date Title
US11590259B2 (en) Composition and kits for pseudoplastic microgel matrices
Safari et al. Exosome-loaded hydrogels: a new cell-free therapeutic approach for skin regeneration
JP2018511622A5 (https=)
Singh et al. Natural polymer-based hydrogels as scaffolds for tissue engineering
Parani et al. Engineered nanomaterials for infection control and healing acute and chronic wounds
JP6997470B2 (ja) ガロール基で修飾されたヒアルロン酸誘導体を基材とするヒドロゲルおよびその用途
US10449257B2 (en) Self-assembled composite ultrasmall peptide-polymer hydrogels
KR101101321B1 (ko) 상처 치유를 위한 하이드로 겔 형태의 세포전달용 비히클 및 그 제조방법
JP6937696B2 (ja) 組織工学型の組織代替系
Datta et al. Oleoyl-chitosan-based nanofiber mats impregnated with amniotic membrane derived stem cells for accelerated full-thickness excisional wound healing
Houacine et al. Potential of natural biomaterials in nano-scale drug delivery
Keshavarz et al. Using biomaterials to improve mesenchymal stem cell therapies for chronic, nonhealing wounds
JP2024506853A (ja) ハイブリッドネットワークヒドロゲルの作製および使用のための組成物および方法
ES2906715T3 (es) Dispositivos de biomaterial para la regeneración de tejidos guiada
JP2025538204A (ja) 組成物およびそれを使用する脂肪移植
Markandeywar et al. A Complete sojorum on thermosensitive hydrogels for wound healing: Recent developments and ongoing research
Vora et al. Injectable depot-forming hydrogels for long-acting drug delivery
Baran Functionalized carboxymethyl Chitosan derivatives in wound healing
US20260061100A1 (en) Methods of treating cartilage with pseudoplastic hydrolyzed collagen-containing compositions
HK1245663B (en) Composition and kits for pseudoplastic microgel matrices
Xu et al. Injectable Hydrogels as a Stem Cell Delivery Platform for Wound Healing
AlAnsari et al. Injectable Smart Hydrogels for Wound Management
CN120531857A (zh) 自组装肽组合物及其应用
Farihatun et al. Biocompatible Hydrogel for Various Tissue Engineering.
Laomeephol Phospholipid-and gold-induced gelation of Thai silk fibroin and its applications for cell and drug delivery

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20171113

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210317

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20221221

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20230718

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20231017

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20231018

End annual number: 3

Start annual number: 1

PG1601 Publication of registration