MX386446B - Composición y kits para matrices pseudoplásticas de microgel. - Google Patents

Composición y kits para matrices pseudoplásticas de microgel.

Info

Publication number
MX386446B
MX386446B MX2017013002A MX2017013002A MX386446B MX 386446 B MX386446 B MX 386446B MX 2017013002 A MX2017013002 A MX 2017013002A MX 2017013002 A MX2017013002 A MX 2017013002A MX 386446 B MX386446 B MX 386446B
Authority
MX
Mexico
Prior art keywords
microgel particles
pseudoplastic
microgel
kits
matrices
Prior art date
Application number
MX2017013002A
Other languages
English (en)
Other versions
MX2017013002A (es
Inventor
Ann Beal Salamone
Eunna Chung
Joseph Charles Salamone
Katelyn Elizabeth Reilly
Kelly Xiaoyu- Chen Leung
Laura Jean Suggs
Original Assignee
Rochal Ind Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rochal Ind Llc filed Critical Rochal Ind Llc
Publication of MX2017013002A publication Critical patent/MX2017013002A/es
Publication of MX386446B publication Critical patent/MX386446B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers & Plastics (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

La invención se refiere en general a partículas de microgel PEGiladas, reticuladas, insolubles en agua, pero hinchables en agua y deformables de proteínas y macro moléculas a base de proteínas que son pseudoplásticas (adelgazamiento por cizallamiento) y fluyen en medios acuosos bajo cizallamiento y que se pueden inyectar o hacer fluir, en donde las partículas de microgel pueden reformarse como una agrupación de partículas de microgel cuando se remueven fuerzas de cizallamiento. Las partículas de microgel funcionan como una matriz para soportar crecimiento, viabilidad, y proliferación celular.
MX2017013002A 2015-04-17 2016-04-12 Composición y kits para matrices pseudoplásticas de microgel. MX386446B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/689,625 US20160303281A1 (en) 2015-04-17 2015-04-17 Composition and kits for pseudoplastic microgel matrices
PCT/US2016/027131 WO2016168196A1 (en) 2015-04-17 2016-04-12 Composition and kits for pseudoplastic microgel matrices

Publications (2)

Publication Number Publication Date
MX2017013002A MX2017013002A (es) 2018-02-01
MX386446B true MX386446B (es) 2025-03-18

Family

ID=57126813

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013002A MX386446B (es) 2015-04-17 2016-04-12 Composición y kits para matrices pseudoplásticas de microgel.

Country Status (13)

Country Link
US (2) US20160303281A1 (es)
EP (1) EP3283057B1 (es)
JP (1) JP6930733B2 (es)
KR (1) KR102592242B1 (es)
CN (1) CN107708675B (es)
AU (1) AU2016250012B2 (es)
BR (1) BR112017022045B1 (es)
CA (1) CA2982352C (es)
DK (1) DK3283057T3 (es)
ES (1) ES2895947T3 (es)
MX (1) MX386446B (es)
PT (1) PT3283057T (es)
WO (1) WO2016168196A1 (es)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102264607B1 (ko) 2014-07-17 2021-06-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자
EP3337426B1 (en) 2015-08-17 2025-04-30 The Johns Hopkins University Mesenchymal cell-binding composite material for tissue restoration
US11931480B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gels and methods of use
CN117582559A (zh) 2016-12-29 2024-02-23 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
IT201700087978A1 (it) 2017-07-31 2019-01-31 Univ Degli Studi Genova Scaffold di idrogel tridimensionale per colture cellulari e metodo per la sua produzione
KR102172222B1 (ko) * 2017-12-29 2020-10-30 서울대학교산학협력단 단백질 약물 전달용 광가교 마이크로젤 및 그의 제조 방법
KR102034872B1 (ko) * 2018-01-10 2019-10-21 주식회사 지투지바이오 콜라겐 펩타이드가 함유된 폴리카프로락톤 미립구 필러 및 그 제조방법
US20190240335A1 (en) * 2018-02-07 2019-08-08 Promedon S.A. Biocompatible Hydrogel Compositions
CN110193094A (zh) * 2018-02-24 2019-09-03 上海优先生物医学工程有限公司 一种软组织填充修复材料及其制备方法和用途
KR102090576B1 (ko) * 2018-02-26 2020-03-18 주식회사 엔도비전 상처치료용 다층 드레싱재
US10335421B1 (en) 2018-02-26 2019-07-02 Aisha Chaudhry Topical wound care formulation
CN108653196A (zh) * 2018-04-11 2018-10-16 燕山大学 一种脂质体复合双响应载药水凝胶的制备方法
CN110402918A (zh) * 2018-04-27 2019-11-05 庄明华 一种保存骨组织材料的方法
KR20210034544A (ko) 2018-05-09 2021-03-30 더 존스 홉킨스 유니버시티 향상된 연조직 대체 및 재생을 위한 나노섬유-하이드로겔 복합재료
JP2021522938A (ja) 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ 細胞及び組織の送達のためのナノファイバー−ハイドロゲル複合体
CN108715833B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种负载血小板裂解液的微球制备方法
GB201810925D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and methods of treatment
CN109224123B (zh) * 2018-10-11 2021-04-09 成都迪康中科生物医学材料有限公司 具有抑制肿瘤作用的纳米羟基磷灰石复合材料及制备方法
CN109298180A (zh) * 2018-11-19 2019-02-01 中南大学 一种检测鼠伤寒沙门氏菌的方法
GB201820021D0 (en) * 2018-12-07 2019-01-23 Univ Birmingham Ocular hydrogel compositions
GB201820018D0 (en) * 2018-12-07 2019-01-23 Univ Birmingham Therapeutic hydrogel compositions
CN109481739B (zh) * 2018-12-12 2021-07-30 四川大学华西医院 一种骨关节润滑剂及其制备方法
US11832879B2 (en) * 2019-03-08 2023-12-05 Neuwave Medical, Inc. Systems and methods for energy delivery
US11065188B2 (en) 2019-05-29 2021-07-20 Av Laboratories Llc Applications and formulations of optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents
CA3142291A1 (en) * 2019-05-31 2020-12-03 Sumitomo Chemical Company, Limited Liquid suspension concentrate formulation comprising mefentrifluconazole
CN110721344B (zh) * 2019-11-21 2020-12-11 北京帝康医药投资管理有限公司 一种用于促进心肌修复的可注射生物凝胶及其制备方法
CN110898250B (zh) * 2019-11-28 2020-11-13 浙江大学 一种用于皮肤移植的自降解水凝胶粘合剂材料及其制备方法
SG10202101181TA (en) * 2020-02-07 2021-09-29 Univ Nanyang Tech Biofunctional hydrogel for wound healing
WO2021174008A1 (en) * 2020-02-28 2021-09-02 University Of Florida Research Foundation Compositions, methods, kits, and systems relating to charge-neutral microgels for 3d cell culture and printing
EP4121131A1 (en) * 2020-03-20 2023-01-25 Bard Peripheral Vascular, Inc. Reactive hydrogel forming formulations and related methods
CN111840654B (zh) * 2020-08-04 2021-05-25 李双宏 一种改性透明质酸复合美容整形材料的制备方法
CN112370567B (zh) * 2020-11-19 2023-05-16 南方医科大学南方医院 一种具有抗菌消炎功能的水凝胶活性敷料
CN112708594B (zh) * 2021-01-26 2022-02-25 中科博生生物工程有限公司 脐带间充质干细胞复苏培养基及其制备方法和应用
CN113332499B (zh) * 2021-03-17 2022-06-28 上海玮沐医疗科技有限公司 一种自控温光热效应微球及其制备方法
JP7454880B2 (ja) * 2021-03-22 2024-03-25 ソンバイオ・インコーポレイテッド ポリエチレングリコール誘導体を有効成分として含む口腔乾燥症緩和用口腔リンス組成物
CN113341146B (zh) * 2021-04-29 2023-06-13 重庆医科大学 用于检测乙肝病毒的比色传感器及其制备与应用
CN113368216A (zh) * 2021-05-28 2021-09-10 薛安全 一种干眼症治疗制剂及其制备方法
IT202100017396A1 (it) * 2021-07-01 2023-01-01 Azienda Unita Sanitaria Locale Della Romagna Metodica di conservazione a temperatura ambiente di tessuti e organi destinati all’uso clinico
WO2023004359A2 (en) * 2021-07-21 2023-01-26 Organogenesis Inc. Porcine collagen compositions and methods of use thereof
CN115814157B (zh) * 2021-09-16 2024-06-07 齐鲁工业大学 一种用于骨整合材料的抗菌性涂层及其制备方法
CN114099776B (zh) * 2021-11-18 2022-09-30 南京工业大学 一种用于组织工程皮肤的颗粒凝胶复合支架及其制备方法
MX2024007071A (es) * 2021-12-09 2024-08-26 Likarda Llc Rellenos de tejido suave a base de micropartículas de hidrogel.
EP4452351A1 (en) * 2021-12-20 2024-10-30 University of Florida Research Foundation, Inc. Microgels, methods of making microgels and methods of using microgels
CN114711326B (zh) * 2021-12-31 2023-09-22 上海食未生物科技有限公司 一种基于悬浮3d打印的食品打印材料、其制备方法和在人造肉中的应用
CN114276989A (zh) * 2021-12-31 2022-04-05 四川大学华西医院 递送脂肪干细胞的微凝胶及其制备方法
CN114307963A (zh) * 2022-01-12 2022-04-12 杭州星宇炭素环保科技有限公司 一种基于废旧棉织品的改性活性炭纤维及应用
CN114404672B (zh) * 2022-01-19 2023-03-03 四川大学 一种联合多酚和抗菌肽的纤维膜及其制备方法和应用
CN115282339B (zh) * 2022-07-28 2023-02-28 四川大学 一种交联透明质酸/羟基磷灰石可注射材料、制备方法及应用
WO2024030661A1 (en) * 2022-08-05 2024-02-08 University Of Washington Systems and methods for selective shape transformation of 3d-printed materials
CN115317665B (zh) * 2022-08-12 2023-08-18 济南格莱威医疗科技有限公司 一种聚酯粒子复合温敏即型凝胶皮下植入剂
KR102819248B1 (ko) * 2022-11-01 2025-06-11 순천향대학교 산학협력단 상처 치유능을 갖는 아가로스 기반 tocn-ecm 이중층 유착방지 하이드로겔
CN115748249B (zh) * 2022-11-23 2024-06-25 浙江诸暨聚源生物技术有限公司 重组胶原蛋白水凝胶纤维及其制备方法
CN115845121B (zh) * 2022-12-07 2024-08-02 华南理工大学 止血、抗菌、促愈合的微凝胶组装体粉末及其制备方法
CN115607740B (zh) * 2022-12-21 2023-04-21 北京德益达美医疗科技有限公司 一种生长因子复合肌腱及其制备方法
WO2024159015A1 (en) * 2023-01-25 2024-08-02 North Carolina State University Compositions and methods relating to inhalable therapeutic compositions
CN121127278A (zh) * 2023-04-20 2025-12-12 香港中文大学 细胞外基质生物材料的制备和调制方法
WO2024254082A1 (en) * 2023-06-05 2024-12-12 Rowan University Compositions and methods for cell culture applications
CN117018269A (zh) * 2023-08-15 2023-11-10 苏州大学 一种仿贻贝多功能丝素蛋白基粘合剂及其制备方法与应用
WO2025128639A1 (en) * 2023-12-12 2025-06-19 The Children's Medical Center Corporation Hydrogels comprising protein-stabilized nanoparticles for extended release
WO2025149946A1 (en) * 2024-01-10 2025-07-17 Biorchestra Co., Ltd. Micellar nanoparticles and uses thereof
WO2025170943A1 (en) * 2024-02-08 2025-08-14 Integral Biosystems Llc Methods and compositions to administer therapeutics to soft tissue surfaces
US20250319020A1 (en) * 2024-02-21 2025-10-16 Vitalte Lifesciences Inc. Dual chamber syringe for administering a hormone encapsulated by a hydrogel
CN119708555B (zh) * 2025-02-28 2025-05-13 成都丁因生物科技有限公司 一种双重修饰的交联透明质酸凝胶制备方法及应用
CN120554666B (zh) * 2025-07-31 2025-11-25 清华大学 自组装微凝胶、微凝胶支架及其制备方法和制备装置

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128305C (es) 1963-09-11
US4172066A (en) 1974-06-21 1979-10-23 The Dow Chemical Company Cross-linked, water-swellable polymer microgels
JPH0739508B2 (ja) * 1986-11-11 1995-05-01 株式会社林原生物化学研究所 プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
WO1994001483A1 (en) * 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
EP0637450A3 (en) * 1993-08-04 1995-04-05 Collagen Corp Method and composition for resuscitation of hereditary tissue.
EP0705298B1 (en) 1993-12-01 2002-03-27 Bioartificial Gel Technologies Inc. Albumin based hydrogel
AU682266B2 (en) 1994-04-04 1997-09-25 Collagen Corporation Cell-gels
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6150505A (en) 1997-09-19 2000-11-21 Hadasit Medical Research Services & Development Ltd. Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US7651703B2 (en) 1999-10-15 2010-01-26 Genentech, Inc. Injection vehicle for polymer-based formulations
US7582311B1 (en) 1999-10-15 2009-09-01 Genentech, Inc. Injection vehicle for polymer-based formulations
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6552172B2 (en) 2001-08-30 2003-04-22 Habto Biotech, Inc. Fibrin nanoparticles and uses thereof
WO2003093433A2 (en) 2002-05-02 2003-11-13 Regents Of The University Of Minnesota Fibrin-based biomatrix
CA2513483C (en) 2003-01-17 2011-11-29 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
NZ543288A (en) 2003-04-30 2009-06-26 Univ Drexel Thermogelling polymer blends for biomaterial applications
EP2289567A3 (en) * 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
WO2005112888A2 (en) 2004-05-20 2005-12-01 Mentor Corporation Methods for making injectable polymer hydrogels
EP1891941A1 (en) * 2006-08-11 2008-02-27 OctoPlus Technologies B.V. Aqueous gels comprising microspheres
MX2009010387A (es) 2007-03-26 2009-10-19 Baxter Int Relleno de vacio inyectable para el aumento de tejido blando.
DK2150282T3 (en) * 2007-04-16 2018-07-23 Regentis Biomaterials Ltd COMPOSITIONS AND PROCEDURES FOR THE formation of a skeleton
US20080268056A1 (en) 2007-04-26 2008-10-30 Abhijeet Joshi Injectable copolymer hydrogel useful for repairing vertebral compression fractures
US20110077737A1 (en) 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
WO2009042514A1 (en) 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
WO2009079555A2 (en) 2007-12-17 2009-06-25 Anna Love Soft tissue filler
WO2009100422A2 (en) * 2008-02-08 2009-08-13 Zimmer, Inc. Drug delivery system comprising microparticles and gelation system
JP5574083B2 (ja) 2008-08-01 2014-08-20 アンタイス エス．エイ． 高い残留性及び容量を与える高い能力を有する注入可能なヒドロゲル
US8557288B2 (en) 2008-08-15 2013-10-15 Washington University Hydrogel microparticle formation in aqueous solvent for biomedical applications
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
IL195764A0 (en) 2008-12-07 2009-11-18 Technion Res & Dev Foundation Compositions and methods for drug delivery
WO2011005381A2 (en) * 2009-06-01 2011-01-13 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
WO2011072399A1 (en) 2009-12-18 2011-06-23 The Governing Council Of The University Of Toronto Injectable polymer composition for use as a cell delivery vehicle
WO2012002986A2 (en) 2009-12-21 2012-01-05 The Regents Of The University Of California Decellularized and delipidized extracellular matrix and methods of use
US20150037422A1 (en) 2012-02-22 2015-02-05 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
US20140170224A1 (en) * 2012-12-14 2014-06-19 Agency For Science, Technology And Research Gelatin-based microgels
KR20180074818A (ko) 2013-02-08 2018-07-03 아셀, 인크. 세포외 기질 재료로부터의 생리활성 겔의 제조 방법

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