KR102564201B1 - 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 - Google Patents

급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 Download PDF

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KR102564201B1
KR102564201B1 KR1020197021537A KR20197021537A KR102564201B1 KR 102564201 B1 KR102564201 B1 KR 102564201B1 KR 1020197021537 A KR1020197021537 A KR 1020197021537A KR 20197021537 A KR20197021537 A KR 20197021537A KR 102564201 B1 KR102564201 B1 KR 102564201B1
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앤드류 피. 크루
키이스 알. 혼버거
징 왕
한칭 동
이민 치안
크레이그 엠. 크루즈
사울 제이미-피게로아
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아비나스 오퍼레이션스, 인코포레이티드
예일 유니버시티
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020197021537A 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 Active KR102564201B1 (ko)

Priority Applications (1)

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KR1020237026280A KR102839545B1 (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438803P 2016-12-23 2016-12-23
US62/438,803 2016-12-23
US201762582698P 2017-11-07 2017-11-07
US62/582,698 2017-11-07
PCT/US2017/068322 WO2018119448A1 (en) 2016-12-23 2017-12-22 Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides

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KR1020237026280A Division KR102839545B1 (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

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KR20190102019A KR20190102019A (ko) 2019-09-02
KR102564201B1 true KR102564201B1 (ko) 2023-08-07

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KR1020257024694A Pending KR20250117470A (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
KR1020237026280A Active KR102839545B1 (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

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KR1020237026280A Active KR102839545B1 (ko) 2016-12-23 2017-12-22 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법

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US (1) US10723717B2 (https=)
EP (1) EP3558994A4 (https=)
JP (3) JP7679173B2 (https=)
KR (3) KR102564201B1 (https=)
CN (2) CN117510491A (https=)
AU (2) AU2017382436C1 (https=)
BR (1) BR112019012878A2 (https=)
CA (1) CA3047784A1 (https=)
CO (1) CO2019007894A2 (https=)
IL (4) IL325835A (https=)
MX (2) MX2019007649A (https=)
WO (1) WO2018119448A1 (https=)

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EP2767532B1 (en) 2012-12-21 2016-07-13 National Institutes for Quantum and Radiological Science and Technology Novel compound for imaging tau protein accumulated in the brain
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
JP6817962B2 (ja) 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法
US12312316B2 (en) 2015-01-20 2025-05-27 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
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