KR102557062B1 - 항-her2 항체-약물 접합체 - Google Patents

항-her2 항체-약물 접합체 Download PDF

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Publication number
KR102557062B1
KR102557062B1 KR1020237008409A KR20237008409A KR102557062B1 KR 102557062 B1 KR102557062 B1 KR 102557062B1 KR 1020237008409 A KR1020237008409 A KR 1020237008409A KR 20237008409 A KR20237008409 A KR 20237008409A KR 102557062 B1 KR102557062 B1 KR 102557062B1
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South Korea
Prior art keywords
antibody
compound
drug
her2
ggfg
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KR1020237008409A
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English (en)
Korean (ko)
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KR20230042126A (ko
Inventor
히로유키 나이토
유스케 오기타니
다케시 마스다
다카시 나카다
마사오 요시다
신지 아시다
고지 모리타
히데키 미야자키
유지 가스야
이치로 하야카와
유키 아베
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다이이찌 산쿄 가부시키가이샤
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Priority to KR1020237024073A priority Critical patent/KR102606930B1/ko
Publication of KR20230042126A publication Critical patent/KR20230042126A/ko
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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