KR102467347B1 - 피라졸로피리미딘 유도체 - Google Patents

피라졸로피리미딘 유도체 Download PDF

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Publication number
KR102467347B1
KR102467347B1 KR1020187032684A KR20187032684A KR102467347B1 KR 102467347 B1 KR102467347 B1 KR 102467347B1 KR 1020187032684 A KR1020187032684 A KR 1020187032684A KR 20187032684 A KR20187032684 A KR 20187032684A KR 102467347 B1 KR102467347 B1 KR 102467347B1
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alkyl
hydrogen
group
methyl
halogenoalkyl
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Korean (ko)
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KR20180134966A (ko
Inventor
아델라인 쾰러
클라우디아 벨츠
키르스텐 뵈르겐
다니엘 쿨케
토마스 일그
요하네스 쾨베르링
발터 휩시
한스-게오르크 슈바르츠
울리히 괴르겐스
울리히 에빙하우스-킨트셔
마이케 힌크
디르크 넨스타일
클라우스 라밍
마르틴 아담체브스키
클라우디아 뵘
닐스 그리베노브
웨이 주앙
Original Assignee
바이엘 애니멀 헬스 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
KR1020187032684A 2016-04-15 2017-04-10 피라졸로피리미딘 유도체 Active KR102467347B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
EP16165572.5 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
KR20180134966A KR20180134966A (ko) 2018-12-19
KR102467347B1 true KR102467347B1 (ko) 2022-11-14

Family

ID=55755480

Family Applications (1)

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KR1020187032684A Active KR102467347B1 (ko) 2016-04-15 2017-04-10 피라졸로피리미딘 유도체

Country Status (22)

Country Link
US (3) US10604525B2 (https=)
EP (1) EP3442974B8 (https=)
JP (1) JP7051703B2 (https=)
KR (1) KR102467347B1 (https=)
CN (1) CN109071545B (https=)
AR (1) AR108130A1 (https=)
AU (1) AU2017251155B2 (https=)
CA (1) CA3020793C (https=)
CL (1) CL2018002920A1 (https=)
CO (1) CO2018010966A2 (https=)
DO (1) DOP2018000226A (https=)
ES (1) ES2953467T3 (https=)
IL (1) IL261885A (https=)
MX (1) MX389697B (https=)
PH (1) PH12018550173A1 (https=)
PL (1) PL3442974T3 (https=)
RU (1) RU2769448C2 (https=)
SG (1) SG11201808214TA (https=)
TW (1) TWI742067B (https=)
UY (1) UY37201A (https=)
WO (1) WO2017178416A1 (https=)
ZA (1) ZA201807656B (https=)

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BR112021024726A2 (pt) * 2019-06-07 2022-01-18 Elanco Tiergesundheit Ag Novos derivados bicíclicos
TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
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CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
WO2022106469A2 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
US20240043446A1 (en) 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
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Also Published As

Publication number Publication date
CL2018002920A1 (es) 2019-02-01
ES2953467T3 (es) 2023-11-13
WO2017178416A1 (en) 2017-10-19
EP3442974B8 (en) 2023-07-12
US20200239482A1 (en) 2020-07-30
CN109071545A (zh) 2018-12-21
MX2018012544A (es) 2019-01-31
US20190071447A1 (en) 2019-03-07
TW201803874A (zh) 2018-02-01
MX389697B (es) 2025-03-20
US20200299299A1 (en) 2020-09-24
CA3020793A1 (en) 2017-10-19
AR108130A1 (es) 2018-07-18
US11001590B2 (en) 2021-05-11
JP7051703B2 (ja) 2022-04-11
UY37201A (es) 2017-11-30
EP3442974C0 (en) 2023-06-07
US10934301B2 (en) 2021-03-02
DOP2018000226A (es) 2018-11-15
RU2018140092A3 (https=) 2020-06-25
NZ747056A (en) 2025-05-30
CA3020793C (en) 2024-05-21
AU2017251155B2 (en) 2021-08-05
RU2018140092A (ru) 2020-05-15
CO2018010966A2 (es) 2018-10-22
CN109071545B (zh) 2021-08-03
KR20180134966A (ko) 2018-12-19
EP3442974B1 (en) 2023-06-07
TWI742067B (zh) 2021-10-11
IL261885A (en) 2018-10-31
PL3442974T3 (pl) 2023-12-04
PH12018550173A1 (en) 2019-07-15
EP3442974A1 (en) 2019-02-20
US10604525B2 (en) 2020-03-31
JP2019513776A (ja) 2019-05-30
SG11201808214TA (en) 2018-10-30
RU2769448C2 (ru) 2022-03-31
AU2017251155A1 (en) 2018-10-11
ZA201807656B (en) 2024-06-26

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