KR102305423B1 - 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 - Google Patents

아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 Download PDF

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KR102305423B1
KR102305423B1 KR1020207007384A KR20207007384A KR102305423B1 KR 102305423 B1 KR102305423 B1 KR 102305423B1 KR 1020207007384 A KR1020207007384 A KR 1020207007384A KR 20207007384 A KR20207007384 A KR 20207007384A KR 102305423 B1 KR102305423 B1 KR 102305423B1
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group
disease
saturated
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KR20200029639A (ko
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알렉산더 헤그먼스
브루스 더블유. 펜스크
댄 제이. 트리패니어
마크 디. 아벨
신 스기야마
대런 알. 유레
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콘트라빌 파마슈티컬스, 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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KR1020207007384A 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 Active KR102305423B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
US61/423,576 2010-12-15
KR1020187037529A KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

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KR1020187037529A Division KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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KR20200029639A KR20200029639A (ko) 2020-03-18
KR102305423B1 true KR102305423B1 (ko) 2021-09-27

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KR1020207007384A Active KR102305423B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
KR1020187037529A Ceased KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
KR1020137016342A Active KR102011339B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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KR1020187037529A Ceased KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
KR1020137016342A Active KR102011339B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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US (2) US9200038B2 (enExample)
EP (2) EP2651965B1 (enExample)
JP (3) JP6144627B2 (enExample)
KR (3) KR102305423B1 (enExample)
CN (2) CN103443119B (enExample)
AU (1) AU2011342284C1 (enExample)
BR (1) BR112013014890B1 (enExample)
CA (1) CA2821009C (enExample)
DK (1) DK2651965T3 (enExample)
ES (1) ES2705750T3 (enExample)
HR (1) HRP20190096T1 (enExample)
HU (1) HUE042490T2 (enExample)
IL (1) IL226792A (enExample)
LT (1) LT2651965T (enExample)
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PT (1) PT2651965T (enExample)
RU (1) RU2630690C9 (enExample)
SG (2) SG191069A1 (enExample)
SI (1) SI2651965T1 (enExample)
TR (1) TR201900128T4 (enExample)
WO (1) WO2012079172A1 (enExample)

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WO2013181339A2 (en) * 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
US20160002299A1 (en) * 2013-03-01 2016-01-07 Ucl Business Plc Non-immunosuppressive cyclosporin derivatives as antiviral agents
HK1223843A1 (zh) * 2013-08-26 2017-08-11 Enanta Pharmaceuticals, Inc. 用於預防或治療丙型肝炎的環孢菌素類似物
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
AU2017267560B2 (en) 2016-05-17 2022-03-24 S&T Global Inc. Novel cyclosporin derivatives and uses thereof
CA3045944A1 (en) 2016-12-07 2018-06-14 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018106928A1 (en) 2016-12-08 2018-06-14 Contravir Pharmaceuticals, Inc. Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3
US11523772B2 (en) 2016-12-14 2022-12-13 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US20180296588A1 (en) 2017-04-14 2018-10-18 Contravir Pharmaceuticals, Inc. Combination therapy for treating viral infections
WO2018193114A1 (en) 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CN121554542A (zh) 2018-08-22 2026-02-24 贝凯恩生物医疗技术有限公司 环孢菌素组合物及使用方法
US12594275B2 (en) 2019-02-07 2026-04-07 The Regents Of The University Of California Immunophilin binding agents and uses thereof
TW202143994A (zh) 2020-02-19 2021-12-01 美商希皮恩製藥公司 環孢素類似物於治療纖維化之用途
CN115484961A (zh) * 2020-02-25 2022-12-16 海必恩制药公司 环孢菌素类似物用于治疗癌症的用途
CA3172535A1 (en) 2020-03-26 2021-09-30 Ching-Pong Mak Cyclophilin inhibitors and uses thereof
WO2021190603A1 (en) * 2020-03-26 2021-09-30 Farsight Medical Technology (Shanghai) Co., Ltd. Cyclophilin inhibitors and uses thereof
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CN113173974B (zh) 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
IT202300001116A1 (it) * 2023-01-25 2024-07-25 Indena Spa Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
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