KR102208283B1 - 인지증 치료제 또는 예방제 - Google Patents

인지증 치료제 또는 예방제 Download PDF

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KR102208283B1
KR102208283B1 KR1020207007010A KR20207007010A KR102208283B1 KR 102208283 B1 KR102208283 B1 KR 102208283B1 KR 1020207007010 A KR1020207007010 A KR 1020207007010A KR 20207007010 A KR20207007010 A KR 20207007010A KR 102208283 B1 KR102208283 B1 KR 102208283B1
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antibody
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thr
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KR20200029619A (ko
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히로시 모리
다카미 도미야마
요이치 마츠모토
히로시 에구치
유이치 구노리
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고리쓰다이가쿠호진 오사카 시리쓰다이가쿠
데이진 화-마 가부시키가이샤
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Publication of KR20200029619A publication Critical patent/KR20200029619A/ko
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Assigned to 코우리츠 다이가꾸 호우진 오사카 reassignment 코우리츠 다이가꾸 호우진 오사카 권리지분의 전부이전등록 Assignors: 고리쓰다이가쿠호진 오사카 시리쓰다이가쿠
Assigned to 데이진 가부시키가이샤 reassignment 데이진 가부시키가이샤 권리지분의 전부이전등록 Assignors: 데이진 화-마 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207007010A 2012-05-31 2013-05-30 인지증 치료제 또는 예방제 Active KR102208283B1 (ko)

Applications Claiming Priority (3)

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JPJP-P-2012-124336 2012-05-31
JP2012124336 2012-05-31
PCT/JP2013/065090 WO2013180238A1 (ja) 2012-05-31 2013-05-30 認知症治療剤又は予防剤

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KR20200029619A KR20200029619A (ko) 2020-03-18
KR102208283B1 true KR102208283B1 (ko) 2021-01-26

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WO2012106363A2 (en) 2011-01-31 2012-08-09 Intellect Neurosciences Inc. Treatment of tauopathies
WO2012162179A1 (en) * 2011-05-20 2012-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
TWI700296B (zh) * 2012-05-31 2020-08-01 公立大學法人大阪市立大學 失智症治療劑或預防劑
EP2870176A4 (en) 2012-07-03 2016-09-28 Univ Washington ANTIBODIES DIRECTED AGAINST TAU
TWI734975B (zh) 2014-06-27 2021-08-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
WO2017189963A1 (en) * 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
JP6785372B2 (ja) * 2016-09-30 2020-11-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性分子の機能分析のためのｓｐｒに基づく二重結合アッセイ
CA3053379A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
JP2018139530A (ja) * 2017-02-27 2018-09-13 帝人ファーマ株式会社 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤
CA3056573A1 (en) 2017-05-30 2018-12-06 Teijin Pharma Limited Anti-igf-i receptor antibody
GEAP202215303A (en) 2017-10-02 2022-04-11 Merck Sharp & Dohme Chromane monobactam compounds for the treatment of bacterial infections
JP6851549B2 (ja) 2017-10-16 2021-03-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗タウ抗体及びその使用
JP7504026B2 (ja) 2018-04-06 2024-06-21 帝人ファーマ株式会社 Ｓｐｎｓ２中和抗体
EP3819378A4 (en) 2018-07-04 2022-09-14 Aichi Medical University OLIGONUCLEOTIDES FOR CONTROL OF TAU SPLICING AND THEIR USES
CN110028583B (zh) * 2019-05-07 2020-09-11 温州医科大学 抗Tau抗体及其在治疗阿尔茨海默病、创伤性脑损伤中的应用
GB2585252A (en) 2019-07-05 2021-01-06 Gen2 Neuroscience Ltd Tau epitope and binding molecules
JP7429404B2 (ja) * 2019-08-06 2024-02-08 慶應義塾 タウ関連疾患モデルの製造方法
JP7718270B2 (ja) 2019-09-30 2025-08-05 ニプロ株式会社 血液試料を検体とするタウタンパク質検出方法
JP2023518281A (ja) * 2020-03-19 2023-04-28 ヴァスキュラー バイオサイエンスィズ コロナウイルス生存率改善のためのｃａｒペプチド
CN116723856A (zh) * 2020-06-25 2023-09-08 默沙东有限责任公司 靶向丝氨酸413处磷酸化的tau的高亲和力抗体
CA3203800A1 (en) * 2021-02-19 2022-08-25 Eisai R&D Management Co., Ltd. Anti-pt217 tau antibody
WO2023092004A1 (en) 2021-11-17 2023-05-25 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
JP2025535203A (ja) 2022-09-15 2025-10-23 ボイジャー セラピューティクス インコーポレイテッド タウ結合化合物
WO2025122634A1 (en) 2023-12-05 2025-06-12 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
WO2026102093A1 (en) 2024-11-07 2026-05-15 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders

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WO1997034145A1 (fr) 1996-03-13 1997-09-18 Mitsubishi Chemical Corporation Anticorps a proteine tau antiphosphorylee et procede de detection de la maladie d'alzheimer l'utilisant
WO2010144711A2 (en) * 2009-06-10 2010-12-16 New York University Immunological targeting of pathological tau proteins

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JP3587390B2 (ja) 1994-03-17 2004-11-10 タカラバイオ株式会社 リン酸化アミノ酸誘導体及びリン酸化ペプチド合成方法
US20080199471A1 (en) * 2002-03-01 2008-08-21 Bernett Matthew J Optimized cd40 antibodies and methods of using the same
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US20070280935A1 (en) * 2006-04-07 2007-12-06 Bernd Bohrmann Antibody that recognizes phosphorylated peptides
JP2009539406A (ja) * 2006-06-16 2009-11-19 エンビボ ファーマシューティカルズ インコーポレイテッド タウおよびアミロイド前駆体断片を発現する遺伝子組換えハエ
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
US8609097B2 (en) 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
WO2012106363A2 (en) * 2011-01-31 2012-08-09 Intellect Neurosciences Inc. Treatment of tauopathies
TR201102696U (tr) * 2011-05-27 2011-06-21 Turhal Sal�H Bağlantısız hareketli ürün reklam standı.
TWI700296B (zh) * 2012-05-31 2020-08-01 公立大學法人大阪市立大學 失智症治療劑或預防劑
JP2018139530A (ja) * 2017-02-27 2018-09-13 帝人ファーマ株式会社 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034145A1 (fr) 1996-03-13 1997-09-18 Mitsubishi Chemical Corporation Anticorps a proteine tau antiphosphorylee et procede de detection de la maladie d'alzheimer l'utilisant
WO2010144711A2 (en) * 2009-06-10 2010-12-16 New York University Immunological targeting of pathological tau proteins
JP2012530055A (ja) 2009-06-10 2012-11-29 ニューヨーク・ユニバーシティ 病理学的タウタンパク質の免疫学的標的化方法

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NZ630536A (en) 2017-03-31
EP3662931B1 (en) 2023-12-06
AU2018200413A1 (en) 2018-02-08
IL235899A0 (en) 2015-01-29
TW201410705A (zh) 2014-03-16
JP6406678B2 (ja) 2018-10-17
HK1210031A1 (en) 2016-04-15
PL2857039T3 (pl) 2020-05-18
PH12014502669B1 (en) 2020-02-19
SG10201805410XA (en) 2018-08-30
JP2016147902A (ja) 2016-08-18
MX361128B (es) 2018-11-28
ZA201409186B (en) 2015-12-23
KR20150027098A (ko) 2015-03-11
HUE046919T2 (hu) 2020-04-28
EP2857039B1 (en) 2019-11-20
AR091218A1 (es) 2015-01-21
EP3662931A1 (en) 2020-06-10
TW202041532A (zh) 2020-11-16
DK2857039T3 (da) 2019-12-16
US20200148753A1 (en) 2020-05-14
TWI700296B (zh) 2020-08-01
JPWO2013180238A1 (ja) 2016-01-21
AU2018200413B2 (en) 2019-10-17
MY172458A (en) 2019-11-26
ES2763361T3 (es) 2020-05-28
HRP20192267T1 (hr) 2020-03-20
MX2014014187A (es) 2015-06-04
RS59802B1 (sr) 2020-02-28
WO2013180238A1 (ja) 2013-12-05
TWI777183B (zh) 2022-09-11
US20220340646A1 (en) 2022-10-27
PT2857039T (pt) 2020-01-07
LT2857039T (lt) 2020-03-10
SI2857039T1 (sl) 2020-03-31
KR102133610B1 (ko) 2020-07-14
RU2657438C2 (ru) 2018-06-13
AU2013268364A1 (en) 2014-12-18
CN104602708B (zh) 2021-11-30
JP6620829B2 (ja) 2019-12-18
CA2875205A1 (en) 2013-12-05
US20150183854A1 (en) 2015-07-02
ES2973070T3 (es) 2024-06-18
BR112014029566A2 (pt) 2017-07-25
CN104602708A (zh) 2015-05-06
RU2014153099A (ru) 2016-07-20
IL235899B (en) 2019-03-31
JP5971659B2 (ja) 2016-08-17
EP2857039A1 (en) 2015-04-08
SG11201407878VA (en) 2015-01-29
EP2857039A4 (en) 2015-08-26
AU2013268364B2 (en) 2018-02-08
CA2875205C (en) 2021-07-20
CY1122530T1 (el) 2021-01-27
JP2018111716A (ja) 2018-07-19
ME03587B (me) 2020-07-20
KR20200029619A (ko) 2020-03-18
PH12014502669A1 (en) 2015-02-02

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