JP5971659B2 - 認知症治療剤又は予防剤 - Google Patents

認知症治療剤又は予防剤 Download PDF

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Publication number
JP5971659B2
JP5971659B2 JP2014518734A JP2014518734A JP5971659B2 JP 5971659 B2 JP5971659 B2 JP 5971659B2 JP 2014518734 A JP2014518734 A JP 2014518734A JP 2014518734 A JP2014518734 A JP 2014518734A JP 5971659 B2 JP5971659 B2 JP 5971659B2
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Prior art keywords
antibody
seq
amino acid
tau
dementia
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Japanese (ja)
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JPWO2013180238A1 (ja
Inventor
森　啓
啓 森
貴美 富山
貴美 富山
松本　洋一
洋一 松本
広志 江口
広志 江口
裕一 九里
裕一 九里
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Teijin Pharma Ltd
Osaka Metropolitan University
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Teijin Pharma Ltd
Osaka City University PUC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014518734A 2012-05-31 2013-05-30 認知症治療剤又は予防剤 Active JP5971659B2 (ja)

Priority Applications (1)

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JP2014518734A JP5971659B2 (ja) 2012-05-31 2013-05-30 認知症治療剤又は予防剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012124336 2012-05-31
JP2012124336 2012-05-31
PCT/JP2013/065090 WO2013180238A1 (ja) 2012-05-31 2013-05-30 認知症治療剤又は予防剤
JP2014518734A JP5971659B2 (ja) 2012-05-31 2013-05-30 認知症治療剤又は予防剤

Related Child Applications (1)

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JP2016094112A Division JP6406678B2 (ja) 2012-05-31 2016-05-09 認知症治療剤又は予防剤

Publications (2)

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JPWO2013180238A1 JPWO2013180238A1 (ja) 2016-01-21
JP5971659B2 true JP5971659B2 (ja) 2016-08-17

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JP2014518734A Active JP5971659B2 (ja) 2012-05-31 2013-05-30 認知症治療剤又は予防剤
JP2016094112A Active JP6406678B2 (ja) 2012-05-31 2016-05-09 認知症治療剤又は予防剤
JP2018051046A Active JP6620829B2 (ja) 2012-05-31 2018-03-19 認知症治療剤又は予防剤

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JP2018051046A Active JP6620829B2 (ja) 2012-05-31 2018-03-19 認知症治療剤又は予防剤

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US (3) US20150183854A1 (enExample)
EP (2) EP2857039B1 (enExample)
JP (3) JP5971659B2 (enExample)
KR (2) KR102208283B1 (enExample)
CN (1) CN104602708B (enExample)
AR (1) AR091218A1 (enExample)
AU (2) AU2013268364B2 (enExample)
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CY (1) CY1122530T1 (enExample)
DK (1) DK2857039T3 (enExample)
ES (2) ES2973070T3 (enExample)
HR (1) HRP20192267T1 (enExample)
HU (1) HUE046919T2 (enExample)
IL (1) IL235899B (enExample)
LT (1) LT2857039T (enExample)
ME (1) ME03587B (enExample)
MX (1) MX361128B (enExample)
MY (1) MY172458A (enExample)
NZ (1) NZ630536A (enExample)
PH (1) PH12014502669B1 (enExample)
PL (1) PL2857039T3 (enExample)
PT (1) PT2857039T (enExample)
RS (1) RS59802B1 (enExample)
RU (1) RU2657438C2 (enExample)
SG (2) SG11201407878VA (enExample)
SI (1) SI2857039T1 (enExample)
TW (2) TWI777183B (enExample)
WO (1) WO2013180238A1 (enExample)
ZA (1) ZA201409186B (enExample)

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JP2018111716A (ja) * 2012-05-31 2018-07-19 公立大学法人大阪市立大学 認知症治療剤又は予防剤

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CA2826286C (en) 2011-01-31 2021-09-21 Intellect Neurosciences Inc. Treatment of tauopathies
EP2709728B1 (en) * 2011-05-20 2019-01-23 Oligomerix, Inc. Tau protease methods of use
MY171473A (en) 2012-07-03 2019-10-15 Univ Washington Antibodies to tau
TW202136296A (zh) 2014-06-27 2021-10-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
US20190224339A1 (en) * 2016-04-29 2019-07-25 Voyager Therapeutics, Inc. Compositions for the treatment of disease
JP6785372B2 (ja) * 2016-09-30 2020-11-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性分子の機能分析のためのｓｐｒに基づく二重結合アッセイ
MA47499A (fr) 2017-02-17 2019-12-25 Denali Therapeutics Inc Anticorps anti-tau et leurs procédés d'utilisation
JOP20180014A1 (ar) * 2017-02-27 2019-01-30 Teijin Pharma Ltd جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه
CN110691794B (zh) 2017-05-30 2023-10-27 帝人制药株式会社 抗igf-i受体抗体
GEP20227406B (en) 2017-10-02 2022-08-25 Merck Sharp & Dohme Chromane monobactam compounds for the treatment of bacterial infections
WO2019077500A1 (en) 2017-10-16 2019-04-25 Eisai R&D Management Co., Ltd. ANTI-WATER ANTIBODIES AND USES THEREOF
JP7504026B2 (ja) 2018-04-06 2024-06-21 帝人ファーマ株式会社 Ｓｐｎｓ２中和抗体
JP7340794B2 (ja) * 2018-07-04 2023-09-08 学校法人 愛知医科大学 タウのスプライシングを制御するアンチセンスオリゴヌクレオチド及びその用途
CN110028583B (zh) * 2019-05-07 2020-09-11 温州医科大学 抗Tau抗体及其在治疗阿尔茨海默病、创伤性脑损伤中的应用
JP7429404B2 (ja) * 2019-08-06 2024-02-08 慶應義塾 タウ関連疾患モデルの製造方法
JP7718270B2 (ja) 2019-09-30 2025-08-05 ニプロ株式会社 血液試料を検体とするタウタンパク質検出方法
EP4121071A4 (en) * 2020-03-19 2024-07-24 Vascular Biosciences PEPTIDE CAR FOR IMPROVED CORONAVIRUS SURVIVAL
BR112022026575A2 (pt) 2020-06-25 2023-01-17 Merck Sharp & Dohme Llc Anticorpos de alta afinidade que alvejam tau fosforilado em serina 413
US20250034559A1 (en) 2021-11-17 2025-01-30 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
AU2023342086A1 (en) 2022-09-15 2025-03-13 Voyager Therapeutics, Inc. Tau binding compounds
WO2025122634A1 (en) 2023-12-05 2025-06-12 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders

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JPS587390B2 (ja) 1975-03-11 1983-02-09 ツキシマキカイ カブシキガイシヤ ア−クヨウセツホウホウ
JP3587390B2 (ja) 1994-03-17 2004-11-10 タカラバイオ株式会社 リン酸化アミノ酸誘導体及びリン酸化ペプチド合成方法
US20020086009A1 (en) * 1996-03-13 2002-07-04 Koichi Ishiguro Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same
US20080199471A1 (en) * 2002-03-01 2008-08-21 Bernett Matthew J Optimized cd40 antibodies and methods of using the same
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US20070280935A1 (en) * 2006-04-07 2007-12-06 Bernd Bohrmann Antibody that recognizes phosphorylated peptides
EP2028932A4 (en) * 2006-06-16 2011-10-12 Vitruvean Llc TAU AND AMYLOID FOREIGNER FRAGMENT EXPRESSING TRANSGENIC FLY
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US8609097B2 (en) 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
US8748386B2 (en) * 2009-06-10 2014-06-10 New York University Immunological targeting of pathological Tau proteins
CA2826286C (en) * 2011-01-31 2021-09-21 Intellect Neurosciences Inc. Treatment of tauopathies
TR201102696U (tr) * 2011-05-27 2011-06-21 Turhal Sal�H Bağlantısız hareketli ürün reklam standı.
MY172458A (en) * 2012-05-31 2019-11-26 Teijin Pharma Ltd Therapeutic agent or prophylactic agent for dementia
JOP20180014A1 (ar) * 2017-02-27 2019-01-30 Teijin Pharma Ltd جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018111716A (ja) * 2012-05-31 2018-07-19 公立大学法人大阪市立大学 認知症治療剤又は予防剤

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JPWO2013180238A1 (ja) 2016-01-21
AR091218A1 (es) 2015-01-21
AU2018200413B2 (en) 2019-10-17
AU2013268364A1 (en) 2014-12-18
CN104602708A (zh) 2015-05-06
WO2013180238A1 (ja) 2013-12-05
JP6406678B2 (ja) 2018-10-17
HUE046919T2 (hu) 2020-04-28
LT2857039T (lt) 2020-03-10
TWI777183B (zh) 2022-09-11
US20220340646A1 (en) 2022-10-27
RU2014153099A (ru) 2016-07-20
MY172458A (en) 2019-11-26
RU2657438C2 (ru) 2018-06-13
HK1210031A1 (en) 2016-04-15
CY1122530T1 (el) 2021-01-27
EP2857039A4 (en) 2015-08-26
ES2763361T3 (es) 2020-05-28
PH12014502669B1 (en) 2020-02-19
MX361128B (es) 2018-11-28
NZ630536A (en) 2017-03-31
KR102133610B1 (ko) 2020-07-14
CA2875205C (en) 2021-07-20
SG11201407878VA (en) 2015-01-29
US20150183854A1 (en) 2015-07-02
EP3662931B1 (en) 2023-12-06
KR20150027098A (ko) 2015-03-11
TWI700296B (zh) 2020-08-01
PL2857039T3 (pl) 2020-05-18
AU2013268364B2 (en) 2018-02-08
AU2018200413A1 (en) 2018-02-08
PT2857039T (pt) 2020-01-07
KR102208283B1 (ko) 2021-01-26
US20200148753A1 (en) 2020-05-14
ZA201409186B (en) 2015-12-23
JP2018111716A (ja) 2018-07-19
CA2875205A1 (en) 2013-12-05
TW201410705A (zh) 2014-03-16
MX2014014187A (es) 2015-06-04
RS59802B1 (sr) 2020-02-28
EP2857039B1 (en) 2019-11-20
HRP20192267T1 (hr) 2020-03-20
BR112014029566A2 (pt) 2017-07-25
ME03587B (me) 2020-07-20
DK2857039T3 (da) 2019-12-16
KR20200029619A (ko) 2020-03-18
TW202041532A (zh) 2020-11-16
SI2857039T1 (sl) 2020-03-31
IL235899B (en) 2019-03-31
SG10201805410XA (en) 2018-08-30
EP3662931A1 (en) 2020-06-10
IL235899A0 (en) 2015-01-29
EP2857039A1 (en) 2015-04-08
JP2016147902A (ja) 2016-08-18
JP6620829B2 (ja) 2019-12-18
CN104602708B (zh) 2021-11-30
PH12014502669A1 (en) 2015-02-02
ES2973070T3 (es) 2024-06-18

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