KR102061482B1 - 섬유근육통 및 만성 피로 증후군을 치료하기 위한 (1r,4r)-6'-플루오로-(N-메틸- 또는 N,N-디메틸-)-4-페닐-4',9'-디하이드로-3'H-스피로-[사이클로헥산-1,1'-피라노[3,4,b]인돌]-4-아민 - Google Patents

섬유근육통 및 만성 피로 증후군을 치료하기 위한 (1r,4r)-6'-플루오로-(N-메틸- 또는 N,N-디메틸-)-4-페닐-4',9'-디하이드로-3'H-스피로-[사이클로헥산-1,1'-피라노[3,4,b]인돌]-4-아민 Download PDF

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KR102061482B1
KR102061482B1 KR1020147024696A KR20147024696A KR102061482B1 KR 102061482 B1 KR102061482 B1 KR 102061482B1 KR 1020147024696 A KR1020147024696 A KR 1020147024696A KR 20147024696 A KR20147024696 A KR 20147024696A KR 102061482 B1 KR102061482 B1 KR 102061482B1
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fibromyalgia
fluoro
spiro
dihydro
phenyl
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KR20140130695A (ko
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슈테파니 프로쉬
클라우스 린츠
페트라 블롬스-푼케
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그뤼넨탈 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020147024696A 2012-02-03 2013-02-01 섬유근육통 및 만성 피로 증후군을 치료하기 위한 (1r,4r)-6'-플루오로-(N-메틸- 또는 N,N-디메틸-)-4-페닐-4',9'-디하이드로-3'H-스피로-[사이클로헥산-1,1'-피라노[3,4,b]인돌]-4-아민 Expired - Fee Related KR102061482B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12000743.0 2012-02-03
EP12000743 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Publications (2)

Publication Number Publication Date
KR20140130695A KR20140130695A (ko) 2014-11-11
KR102061482B1 true KR102061482B1 (ko) 2020-01-03

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KR1020147024696A Expired - Fee Related KR102061482B1 (ko) 2012-02-03 2013-02-01 섬유근육통 및 만성 피로 증후군을 치료하기 위한 (1r,4r)-6'-플루오로-(N-메틸- 또는 N,N-디메틸-)-4-페닐-4',9'-디하이드로-3'H-스피로-[사이클로헥산-1,1'-피라노[3,4,b]인돌]-4-아민

Country Status (23)

Country Link
US (1) US20130202701A1 (enExample)
EP (1) EP2809320B1 (enExample)
JP (1) JP6126134B2 (enExample)
KR (1) KR102061482B1 (enExample)
CN (1) CN104168897B (enExample)
AU (1) AU2013214223B2 (enExample)
BR (1) BR112014019136A8 (enExample)
CA (1) CA2863572C (enExample)
CY (1) CY1118799T1 (enExample)
DK (1) DK2809320T3 (enExample)
EA (1) EA025500B1 (enExample)
ES (1) ES2629211T3 (enExample)
HR (1) HRP20170581T1 (enExample)
IL (1) IL233871B (enExample)
LT (1) LT2809320T (enExample)
MX (1) MX353740B (enExample)
NZ (1) NZ629800A (enExample)
PL (1) PL2809320T3 (enExample)
PT (1) PT2809320T (enExample)
RS (1) RS56097B1 (enExample)
SI (1) SI2809320T1 (enExample)
WO (1) WO2013113857A1 (enExample)
ZA (1) ZA201406447B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066183A1 (de) 2003-12-23 2005-07-21 Grünenthal GmbH Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor
US20080125475A1 (en) 2006-09-29 2008-05-29 Grunenthal Gmbh Mixed ORL1/mu-agonists for the treatment of pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
BRPI0509377A (pt) * 2004-03-29 2007-09-11 Pfizer compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1
MX2008015048A (es) * 2006-05-31 2008-12-10 Sepracor Inc Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066183A1 (de) 2003-12-23 2005-07-21 Grünenthal GmbH Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor
US20080125475A1 (en) 2006-09-29 2008-05-29 Grunenthal Gmbh Mixed ORL1/mu-agonists for the treatment of pain

Also Published As

Publication number Publication date
HK1199218A1 (en) 2015-06-26
AU2013214223B2 (en) 2017-03-23
US20130202701A1 (en) 2013-08-08
CN104168897A (zh) 2014-11-26
CA2863572C (en) 2019-08-27
EA201400857A1 (ru) 2015-01-30
EA025500B1 (ru) 2016-12-30
ES2629211T3 (es) 2017-08-07
JP6126134B2 (ja) 2017-05-10
CA2863572A1 (en) 2013-08-08
KR20140130695A (ko) 2014-11-11
NZ629800A (en) 2016-06-24
ZA201406447B (en) 2016-02-24
EP2809320A1 (en) 2014-12-10
IL233871B (en) 2018-06-28
PT2809320T (pt) 2017-06-30
SI2809320T1 (sl) 2017-07-31
WO2013113857A1 (en) 2013-08-08
BR112014019136A2 (enExample) 2017-06-20
IL233871A0 (en) 2014-09-30
MX353740B (es) 2018-01-26
PL2809320T3 (pl) 2017-09-29
DK2809320T3 (en) 2017-05-15
RS56097B1 (sr) 2017-10-31
MX2014008865A (es) 2014-08-27
BR112014019136A8 (pt) 2017-07-11
EP2809320B1 (en) 2017-03-22
CY1118799T1 (el) 2018-01-10
CN104168897B (zh) 2016-09-28
AU2013214223A1 (en) 2014-09-18
HRP20170581T1 (hr) 2017-06-16
JP2015505553A (ja) 2015-02-23
LT2809320T (lt) 2017-05-25

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