DK2809320T3 - (1r, 4r) -6'-fluoro- (n-methyl or N, N-dimethyl) -4-phenyl-4 ', 9'-dihydro-3'H-spiro- [cyclohexane-1,1'- pyran [3,4, b] indole] -4-amine for the treatment of fibromyalgia and chronic fatigue syndrome. - Google Patents
(1r, 4r) -6'-fluoro- (n-methyl or N, N-dimethyl) -4-phenyl-4 ', 9'-dihydro-3'H-spiro- [cyclohexane-1,1'- pyran [3,4, b] indole] -4-amine for the treatment of fibromyalgia and chronic fatigue syndrome. Download PDFInfo
- Publication number
- DK2809320T3 DK2809320T3 DK13701807.3T DK13701807T DK2809320T3 DK 2809320 T3 DK2809320 T3 DK 2809320T3 DK 13701807 T DK13701807 T DK 13701807T DK 2809320 T3 DK2809320 T3 DK 2809320T3
- Authority
- DK
- Denmark
- Prior art keywords
- fibromyalgia
- dosage form
- pharmaceutical dosage
- treatment
- chronic fatigue
- Prior art date
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- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
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- 229920000053 polysorbate 80 Polymers 0.000 description 1
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- WECGLUPZRHILCT-HZJYTTRNSA-N rac-1-monolinoleoylglycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC(O)CO WECGLUPZRHILCT-HZJYTTRNSA-N 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
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- 229940080236 sodium cetyl sulfate Drugs 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- OABYVIYXWMZFFJ-ZUHYDKSRSA-M sodium glycocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 OABYVIYXWMZFFJ-ZUHYDKSRSA-M 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 1
- QGLITUFXHVRMGV-UHFFFAOYSA-M sodium;tetratriacontyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCOS([O-])(=O)=O QGLITUFXHVRMGV-UHFFFAOYSA-M 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
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- 229940035048 sorbitan monostearate Drugs 0.000 description 1
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- 239000007921 spray Substances 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- 238000012762 unpaired Student’s t-test Methods 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12000743 | 2012-02-03 | ||
| PCT/EP2013/051979 WO2013113857A1 (en) | 2012-02-03 | 2013-02-01 | (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2809320T3 true DK2809320T3 (en) | 2017-05-15 |
Family
ID=47628188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13701807.3T DK2809320T3 (en) | 2012-02-03 | 2013-02-01 | (1r, 4r) -6'-fluoro- (n-methyl or N, N-dimethyl) -4-phenyl-4 ', 9'-dihydro-3'H-spiro- [cyclohexane-1,1'- pyran [3,4, b] indole] -4-amine for the treatment of fibromyalgia and chronic fatigue syndrome. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20130202701A1 (enExample) |
| EP (1) | EP2809320B1 (enExample) |
| JP (1) | JP6126134B2 (enExample) |
| KR (1) | KR102061482B1 (enExample) |
| CN (1) | CN104168897B (enExample) |
| AU (1) | AU2013214223B2 (enExample) |
| BR (1) | BR112014019136A8 (enExample) |
| CA (1) | CA2863572C (enExample) |
| CY (1) | CY1118799T1 (enExample) |
| DK (1) | DK2809320T3 (enExample) |
| EA (1) | EA025500B1 (enExample) |
| ES (1) | ES2629211T3 (enExample) |
| HR (1) | HRP20170581T1 (enExample) |
| IL (1) | IL233871B (enExample) |
| LT (1) | LT2809320T (enExample) |
| MX (1) | MX353740B (enExample) |
| NZ (1) | NZ629800A (enExample) |
| PL (1) | PL2809320T3 (enExample) |
| PT (1) | PT2809320T (enExample) |
| RS (1) | RS56097B1 (enExample) |
| SI (1) | SI2809320T1 (enExample) |
| WO (1) | WO2013113857A1 (enExample) |
| ZA (1) | ZA201406447B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10022353B2 (en) | 2015-01-23 | 2018-07-17 | Grünenthal GmbH | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900420A (en) * | 1997-06-19 | 1999-05-04 | Cole; William L. | Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| BRPI0509377A (pt) * | 2004-03-29 | 2007-09-11 | Pfizer | compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1 |
| MX2008015048A (es) * | 2006-05-31 | 2008-12-10 | Sepracor Inc | Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida. |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
-
2013
- 2013-02-01 LT LTEP13701807.3T patent/LT2809320T/lt unknown
- 2013-02-01 US US13/757,223 patent/US20130202701A1/en not_active Abandoned
- 2013-02-01 SI SI201330672A patent/SI2809320T1/sl unknown
- 2013-02-01 MX MX2014008865A patent/MX353740B/es active IP Right Grant
- 2013-02-01 HR HRP20170581TT patent/HRP20170581T1/hr unknown
- 2013-02-01 DK DK13701807.3T patent/DK2809320T3/en active
- 2013-02-01 JP JP2014555212A patent/JP6126134B2/ja active Active
- 2013-02-01 RS RS20170602A patent/RS56097B1/sr unknown
- 2013-02-01 NZ NZ629800A patent/NZ629800A/en not_active IP Right Cessation
- 2013-02-01 CA CA2863572A patent/CA2863572C/en not_active Expired - Fee Related
- 2013-02-01 AU AU2013214223A patent/AU2013214223B2/en not_active Ceased
- 2013-02-01 ES ES13701807.3T patent/ES2629211T3/es active Active
- 2013-02-01 EA EA201400857A patent/EA025500B1/ru not_active IP Right Cessation
- 2013-02-01 BR BR112014019136A patent/BR112014019136A8/pt not_active Application Discontinuation
- 2013-02-01 PL PL13701807T patent/PL2809320T3/pl unknown
- 2013-02-01 KR KR1020147024696A patent/KR102061482B1/ko not_active Expired - Fee Related
- 2013-02-01 EP EP13701807.3A patent/EP2809320B1/en active Active
- 2013-02-01 CN CN201380007809.0A patent/CN104168897B/zh not_active Expired - Fee Related
- 2013-02-01 PT PT137018073T patent/PT2809320T/pt unknown
- 2013-02-01 WO PCT/EP2013/051979 patent/WO2013113857A1/en not_active Ceased
-
2014
- 2014-07-30 IL IL233871A patent/IL233871B/en active IP Right Grant
- 2014-09-02 ZA ZA2014/06447A patent/ZA201406447B/en unknown
-
2017
- 2017-04-03 CY CY20171100395T patent/CY1118799T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1199218A1 (en) | 2015-06-26 |
| AU2013214223B2 (en) | 2017-03-23 |
| US20130202701A1 (en) | 2013-08-08 |
| CN104168897A (zh) | 2014-11-26 |
| CA2863572C (en) | 2019-08-27 |
| EA201400857A1 (ru) | 2015-01-30 |
| EA025500B1 (ru) | 2016-12-30 |
| ES2629211T3 (es) | 2017-08-07 |
| JP6126134B2 (ja) | 2017-05-10 |
| CA2863572A1 (en) | 2013-08-08 |
| KR102061482B1 (ko) | 2020-01-03 |
| KR20140130695A (ko) | 2014-11-11 |
| NZ629800A (en) | 2016-06-24 |
| ZA201406447B (en) | 2016-02-24 |
| EP2809320A1 (en) | 2014-12-10 |
| IL233871B (en) | 2018-06-28 |
| PT2809320T (pt) | 2017-06-30 |
| SI2809320T1 (sl) | 2017-07-31 |
| WO2013113857A1 (en) | 2013-08-08 |
| BR112014019136A2 (enExample) | 2017-06-20 |
| IL233871A0 (en) | 2014-09-30 |
| MX353740B (es) | 2018-01-26 |
| PL2809320T3 (pl) | 2017-09-29 |
| RS56097B1 (sr) | 2017-10-31 |
| MX2014008865A (es) | 2014-08-27 |
| BR112014019136A8 (pt) | 2017-07-11 |
| EP2809320B1 (en) | 2017-03-22 |
| CY1118799T1 (el) | 2018-01-10 |
| CN104168897B (zh) | 2016-09-28 |
| AU2013214223A1 (en) | 2014-09-18 |
| HRP20170581T1 (hr) | 2017-06-16 |
| JP2015505553A (ja) | 2015-02-23 |
| LT2809320T (lt) | 2017-05-25 |
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