JP6126134B2 - 線維筋痛症および慢性疲労症候群の治療のための、(1r,4r)−6’−フルオロ−(N−メチル−またはN,N−ジメチル−)−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミン - Google Patents

線維筋痛症および慢性疲労症候群の治療のための、(1r,4r)−6’−フルオロ−(N−メチル−またはN,N−ジメチル−)−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミン Download PDF

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JP6126134B2
JP6126134B2 JP2014555212A JP2014555212A JP6126134B2 JP 6126134 B2 JP6126134 B2 JP 6126134B2 JP 2014555212 A JP2014555212 A JP 2014555212A JP 2014555212 A JP2014555212 A JP 2014555212A JP 6126134 B2 JP6126134 B2 JP 6126134B2
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fibromyalgia
indole
fluoro
pyrano
spiro
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JP2015505553A5 (enExample
JP2015505553A (ja
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フロッシュ・シュテファニー
リンツ・クラウス
ブロムス−フンケ・ペトラ
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グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2014555212A 2012-02-03 2013-02-01 線維筋痛症および慢性疲労症候群の治療のための、(1r,4r)−6’−フルオロ−(N−メチル−またはN,N−ジメチル−)−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミン Active JP6126134B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12000743.0 2012-02-03
EP12000743 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

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JP2015505553A JP2015505553A (ja) 2015-02-23
JP2015505553A5 JP2015505553A5 (enExample) 2016-03-31
JP6126134B2 true JP6126134B2 (ja) 2017-05-10

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JP2014555212A Active JP6126134B2 (ja) 2012-02-03 2013-02-01 線維筋痛症および慢性疲労症候群の治療のための、(1r,4r)−6’−フルオロ−(N−メチル−またはN,N−ジメチル−)−4−フェニル−4’,9’−ジヒドロ−3’H−スピロ[シクロヘキサン−1,1’−ピラノ[3,4,b]インドール]−4−アミン

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US (1) US20130202701A1 (enExample)
EP (1) EP2809320B1 (enExample)
JP (1) JP6126134B2 (enExample)
KR (1) KR102061482B1 (enExample)
CN (1) CN104168897B (enExample)
AU (1) AU2013214223B2 (enExample)
BR (1) BR112014019136A8 (enExample)
CA (1) CA2863572C (enExample)
CY (1) CY1118799T1 (enExample)
DK (1) DK2809320T3 (enExample)
EA (1) EA025500B1 (enExample)
ES (1) ES2629211T3 (enExample)
HR (1) HRP20170581T1 (enExample)
IL (1) IL233871B (enExample)
LT (1) LT2809320T (enExample)
MX (1) MX353740B (enExample)
NZ (1) NZ629800A (enExample)
PL (1) PL2809320T3 (enExample)
PT (1) PT2809320T (enExample)
RS (1) RS56097B1 (enExample)
SI (1) SI2809320T1 (enExample)
WO (1) WO2013113857A1 (enExample)
ZA (1) ZA201406447B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
BRPI0509377A (pt) * 2004-03-29 2007-09-11 Pfizer compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1
MX2008015048A (es) * 2006-05-31 2008-12-10 Sepracor Inc Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida.
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

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HK1199218A1 (en) 2015-06-26
AU2013214223B2 (en) 2017-03-23
US20130202701A1 (en) 2013-08-08
CN104168897A (zh) 2014-11-26
CA2863572C (en) 2019-08-27
EA201400857A1 (ru) 2015-01-30
EA025500B1 (ru) 2016-12-30
ES2629211T3 (es) 2017-08-07
CA2863572A1 (en) 2013-08-08
KR102061482B1 (ko) 2020-01-03
KR20140130695A (ko) 2014-11-11
NZ629800A (en) 2016-06-24
ZA201406447B (en) 2016-02-24
EP2809320A1 (en) 2014-12-10
IL233871B (en) 2018-06-28
PT2809320T (pt) 2017-06-30
SI2809320T1 (sl) 2017-07-31
WO2013113857A1 (en) 2013-08-08
BR112014019136A2 (enExample) 2017-06-20
IL233871A0 (en) 2014-09-30
MX353740B (es) 2018-01-26
PL2809320T3 (pl) 2017-09-29
DK2809320T3 (en) 2017-05-15
RS56097B1 (sr) 2017-10-31
MX2014008865A (es) 2014-08-27
BR112014019136A8 (pt) 2017-07-11
EP2809320B1 (en) 2017-03-22
CY1118799T1 (el) 2018-01-10
CN104168897B (zh) 2016-09-28
AU2013214223A1 (en) 2014-09-18
HRP20170581T1 (hr) 2017-06-16
JP2015505553A (ja) 2015-02-23
LT2809320T (lt) 2017-05-25

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