LT2809320T - (1r,4r)-6`-fluor-(n-metil- arba n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro-[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas fibromialgijos ir lėtinio nuovargio sindromo gydymui - Google Patents

(1r,4r)-6`-fluor-(n-metil- arba n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro-[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas fibromialgijos ir lėtinio nuovargio sindromo gydymui

Info

Publication number
LT2809320T
LT2809320T LTEP13701807.3T LT13701807T LT2809320T LT 2809320 T LT2809320 T LT 2809320T LT 13701807 T LT13701807 T LT 13701807T LT 2809320 T LT2809320 T LT 2809320T
Authority
LT
Lithuania
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
LTEP13701807.3T
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Petra Bloms-Funke
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of LT2809320T publication Critical patent/LT2809320T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
LTEP13701807.3T 2012-02-03 2013-02-01 (1r,4r)-6`-fluor-(n-metil- arba n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro-[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas fibromialgijos ir lėtinio nuovargio sindromo gydymui LT2809320T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12000743 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Publications (1)

Publication Number Publication Date
LT2809320T true LT2809320T (lt) 2017-05-25

Family

ID=47628188

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13701807.3T LT2809320T (lt) 2012-02-03 2013-02-01 (1r,4r)-6`-fluor-(n-metil- arba n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro-[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas fibromialgijos ir lėtinio nuovargio sindromo gydymui

Country Status (24)

Country Link
US (1) US20130202701A1 (lt)
EP (1) EP2809320B1 (lt)
JP (1) JP6126134B2 (lt)
KR (1) KR102061482B1 (lt)
CN (1) CN104168897B (lt)
AU (1) AU2013214223B2 (lt)
BR (1) BR112014019136A8 (lt)
CA (1) CA2863572C (lt)
CY (1) CY1118799T1 (lt)
DK (1) DK2809320T3 (lt)
EA (1) EA025500B1 (lt)
ES (1) ES2629211T3 (lt)
HK (1) HK1199218A1 (lt)
HR (1) HRP20170581T1 (lt)
IL (1) IL233871B (lt)
LT (1) LT2809320T (lt)
MX (1) MX353740B (lt)
NZ (1) NZ629800A (lt)
PL (1) PL2809320T3 (lt)
PT (1) PT2809320T (lt)
RS (1) RS56097B1 (lt)
SI (1) SI2809320T1 (lt)
WO (1) WO2013113857A1 (lt)
ZA (1) ZA201406447B (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016208779B2 (en) 2015-01-23 2020-11-12 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US7354925B2 (en) * 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
KR20090015089A (ko) * 2006-05-31 2009-02-11 세프라코 아이엔시. 트랜스 4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로-1-나프탈렌아민 및 그의 포름아미드에 의한 통증장애 치료방법
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Also Published As

Publication number Publication date
BR112014019136A8 (pt) 2017-07-11
AU2013214223A1 (en) 2014-09-18
MX353740B (es) 2018-01-26
CA2863572C (en) 2019-08-27
ES2629211T3 (es) 2017-08-07
BR112014019136A2 (lt) 2017-06-20
SI2809320T1 (sl) 2017-07-31
CN104168897B (zh) 2016-09-28
ZA201406447B (en) 2016-02-24
PT2809320T (pt) 2017-06-30
AU2013214223B2 (en) 2017-03-23
IL233871B (en) 2018-06-28
JP2015505553A (ja) 2015-02-23
KR20140130695A (ko) 2014-11-11
EA025500B1 (ru) 2016-12-30
CY1118799T1 (el) 2018-01-10
EA201400857A1 (ru) 2015-01-30
WO2013113857A1 (en) 2013-08-08
HRP20170581T1 (hr) 2017-06-16
KR102061482B1 (ko) 2020-01-03
EP2809320B1 (en) 2017-03-22
RS56097B1 (sr) 2017-10-31
IL233871A0 (en) 2014-09-30
MX2014008865A (es) 2014-08-27
CA2863572A1 (en) 2013-08-08
PL2809320T3 (pl) 2017-09-29
CN104168897A (zh) 2014-11-26
EP2809320A1 (en) 2014-12-10
NZ629800A (en) 2016-06-24
JP6126134B2 (ja) 2017-05-10
HK1199218A1 (en) 2015-06-26
US20130202701A1 (en) 2013-08-08
DK2809320T3 (en) 2017-05-15

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