HRP20170581T1 - (1r,4r)-6'-fluor-(n-metil- ili n,n-dimetil)-(-4-fenil-4',9'-dihidro-3'h-spiro-[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje fibromialgije i sindroma kroničnog umora - Google Patents
(1r,4r)-6'-fluor-(n-metil- ili n,n-dimetil)-(-4-fenil-4',9'-dihidro-3'h-spiro-[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje fibromialgije i sindroma kroničnog umora Download PDFInfo
- Publication number
- HRP20170581T1 HRP20170581T1 HRP20170581TT HRP20170581T HRP20170581T1 HR P20170581 T1 HRP20170581 T1 HR P20170581T1 HR P20170581T T HRP20170581T T HR P20170581TT HR P20170581 T HRP20170581 T HR P20170581T HR P20170581 T1 HRP20170581 T1 HR P20170581T1
- Authority
- HR
- Croatia
- Prior art keywords
- fibromyalgia
- treatment
- dosage form
- pharmaceutical dosage
- chronic fatigue
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title claims 3
- 208000011580 syndromic disease Diseases 0.000 title claims 2
- 230000001684 chronic effect Effects 0.000 title 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 18
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 9
- 239000002552 dosage form Substances 0.000 claims 9
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Claims (9)
1. Farmaceutski dozni oblik koji sadrži farmakološki aktivni spoj prema općoj formuli (I)gdje R je –H ili CH3, ili njegova fiziološki prihvatljiva sol, za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora.
2. Farmaceutski dozni oblik prema zahtjevu 1 za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema zahtjevu 1, gdje je farmakološki aktivni spoj (1R,4R)-6'-fluor-N,N-dimetil-4-fenil-4',9'-dihidro-3'H-spiro-[cikloheksan-1,1'-pirano[3,4,B]indol]-4-amin ili njegova fiziološki prihvatljiva sol.
3. Farmaceutski dozni oblik prema zahtjevu 1 ili 2 za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema zahtjevu 1 ili 2, gdje je fibromialgija odabrana od fibromiositisa, fibrositisa, miofibrositisa, difuznog sindroma miofascijalne boli, primarne fibromialgije, sekundarne fibromialgije, fibromialgija-firomiositis sindroma, fibromiositis-fibromialgija sindroma, te mišićnog reumatizma.
4. Farmaceutski dozni oblik prema bilo kojem od prethodnih zahtjeva za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema bilo kojem od prethodnih zahtjeva, koji je za administraciju jednom dnevno ili dvaput dnevno.
5. Farmaceutski dozni oblik prema bilo kojem od prethodnih zahtjeva za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema bilo kojem od prethodnih zahtjeva, koji je za oralnu administraciju.
6. Farmaceutski dozni oblik prema zahtjevu 5 za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema zahtjevu 5, koji je odabran iz skupine koja se sastoji od tableta, tableta za žvakanje, premazanih tableta, kapsula, granula, dražeja, sokova ili sirupa.
7. Farmaceutski dozni oblik prema bilo kojem od prethodnih zahtjeva za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema bilo kojem od prethodnih zahtjeva, koji je za administraciju sisavcu, poželjno čovjeku.
8. Farmaceutski dozni oblik prema bilo kojem od prethodnih zahtjeva za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema bilo kojem od prethodnih zahtjeva, koji je za administraciju odraslom čovjeku.
9. Farmaceutski dozni oblik prema zahtjevu 8 za upotrebu u liječenju fibromialgije ili sindroma kroničnog umora prema zahtjevu 8, gdje je odrasli čovjek gerijatrični pacijent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12000743 | 2012-02-03 | ||
| PCT/EP2013/051979 WO2013113857A1 (en) | 2012-02-03 | 2013-02-01 | (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome |
| EP13701807.3A EP2809320B1 (en) | 2012-02-03 | 2013-02-01 | (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170581T1 true HRP20170581T1 (hr) | 2017-06-16 |
Family
ID=47628188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170581TT HRP20170581T1 (hr) | 2012-02-03 | 2017-04-11 | (1r,4r)-6'-fluor-(n-metil- ili n,n-dimetil)-(-4-fenil-4',9'-dihidro-3'h-spiro-[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje fibromialgije i sindroma kroničnog umora |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20130202701A1 (hr) |
| EP (1) | EP2809320B1 (hr) |
| JP (1) | JP6126134B2 (hr) |
| KR (1) | KR102061482B1 (hr) |
| CN (1) | CN104168897B (hr) |
| AU (1) | AU2013214223B2 (hr) |
| BR (1) | BR112014019136A8 (hr) |
| CA (1) | CA2863572C (hr) |
| CY (1) | CY1118799T1 (hr) |
| DK (1) | DK2809320T3 (hr) |
| EA (1) | EA025500B1 (hr) |
| ES (1) | ES2629211T3 (hr) |
| HK (1) | HK1199218A1 (hr) |
| HR (1) | HRP20170581T1 (hr) |
| IL (1) | IL233871B (hr) |
| LT (1) | LT2809320T (hr) |
| MX (1) | MX353740B (hr) |
| NZ (1) | NZ629800A (hr) |
| PL (1) | PL2809320T3 (hr) |
| PT (1) | PT2809320T (hr) |
| RS (1) | RS56097B1 (hr) |
| SI (1) | SI2809320T1 (hr) |
| WO (1) | WO2013113857A1 (hr) |
| ZA (1) | ZA201406447B (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900420A (en) * | 1997-06-19 | 1999-05-04 | Cole; William L. | Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1732893A2 (en) * | 2004-03-29 | 2006-12-20 | Pfizer Japan, Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist |
| WO2007143267A2 (en) * | 2006-05-31 | 2007-12-13 | Sepracor Inc. | Treatment of pain disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine and its formamide |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
-
2013
- 2013-02-01 BR BR112014019136A patent/BR112014019136A8/pt not_active Application Discontinuation
- 2013-02-01 SI SI201330672A patent/SI2809320T1/sl unknown
- 2013-02-01 EP EP13701807.3A patent/EP2809320B1/en active Active
- 2013-02-01 MX MX2014008865A patent/MX353740B/es active IP Right Grant
- 2013-02-01 WO PCT/EP2013/051979 patent/WO2013113857A1/en active Application Filing
- 2013-02-01 KR KR1020147024696A patent/KR102061482B1/ko active IP Right Grant
- 2013-02-01 PL PL13701807T patent/PL2809320T3/pl unknown
- 2013-02-01 NZ NZ629800A patent/NZ629800A/en not_active IP Right Cessation
- 2013-02-01 PT PT137018073T patent/PT2809320T/pt unknown
- 2013-02-01 DK DK13701807.3T patent/DK2809320T3/en active
- 2013-02-01 RS RS20170602A patent/RS56097B1/sr unknown
- 2013-02-01 LT LTEP13701807.3T patent/LT2809320T/lt unknown
- 2013-02-01 US US13/757,223 patent/US20130202701A1/en not_active Abandoned
- 2013-02-01 CN CN201380007809.0A patent/CN104168897B/zh not_active Expired - Fee Related
- 2013-02-01 EA EA201400857A patent/EA025500B1/ru not_active IP Right Cessation
- 2013-02-01 JP JP2014555212A patent/JP6126134B2/ja active Active
- 2013-02-01 AU AU2013214223A patent/AU2013214223B2/en not_active Ceased
- 2013-02-01 CA CA2863572A patent/CA2863572C/en not_active Expired - Fee Related
- 2013-02-01 ES ES13701807.3T patent/ES2629211T3/es active Active
-
2014
- 2014-07-30 IL IL233871A patent/IL233871B/en active IP Right Grant
- 2014-09-02 ZA ZA2014/06447A patent/ZA201406447B/en unknown
- 2014-12-23 HK HK14112866.0A patent/HK1199218A1/xx not_active IP Right Cessation
-
2017
- 2017-04-03 CY CY20171100395T patent/CY1118799T1/el unknown
- 2017-04-11 HR HRP20170581TT patent/HRP20170581T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2809320T3 (pl) | 2017-09-29 |
| CA2863572A1 (en) | 2013-08-08 |
| AU2013214223B2 (en) | 2017-03-23 |
| CN104168897B (zh) | 2016-09-28 |
| RS56097B1 (sr) | 2017-10-31 |
| CY1118799T1 (el) | 2018-01-10 |
| CA2863572C (en) | 2019-08-27 |
| JP2015505553A (ja) | 2015-02-23 |
| EP2809320A1 (en) | 2014-12-10 |
| HK1199218A1 (en) | 2015-06-26 |
| ZA201406447B (en) | 2016-02-24 |
| KR20140130695A (ko) | 2014-11-11 |
| LT2809320T (lt) | 2017-05-25 |
| KR102061482B1 (ko) | 2020-01-03 |
| IL233871B (en) | 2018-06-28 |
| PT2809320T (pt) | 2017-06-30 |
| ES2629211T3 (es) | 2017-08-07 |
| BR112014019136A2 (hr) | 2017-06-20 |
| NZ629800A (en) | 2016-06-24 |
| MX2014008865A (es) | 2014-08-27 |
| WO2013113857A1 (en) | 2013-08-08 |
| EP2809320B1 (en) | 2017-03-22 |
| BR112014019136A8 (pt) | 2017-07-11 |
| EA025500B1 (ru) | 2016-12-30 |
| US20130202701A1 (en) | 2013-08-08 |
| SI2809320T1 (sl) | 2017-07-31 |
| JP6126134B2 (ja) | 2017-05-10 |
| DK2809320T3 (en) | 2017-05-15 |
| CN104168897A (zh) | 2014-11-26 |
| AU2013214223A1 (en) | 2014-09-18 |
| MX353740B (es) | 2018-01-26 |
| IL233871A0 (en) | 2014-09-30 |
| EA201400857A1 (ru) | 2015-01-30 |
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