EA201401267A1 - Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и компонент салициловой кислоты - Google Patents

Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и компонент салициловой кислоты

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Publication number
EA201401267A1
EA201401267A1 EA201401267A EA201401267A EA201401267A1 EA 201401267 A1 EA201401267 A1 EA 201401267A1 EA 201401267 A EA201401267 A EA 201401267A EA 201401267 A EA201401267 A EA 201401267A EA 201401267 A1 EA201401267 A1 EA 201401267A1
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EA
Eurasian Patent Office
Prior art keywords
salicylic acid
spiro
dihydro
fluoro
dimethyl
Prior art date
Application number
EA201401267A
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English (en)
Other versions
EA026642B1 (ru
Inventor
Штефани Фрош
Клаус Линц
Клаус Шине
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Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401267A1 publication Critical patent/EA201401267A1/ru
Publication of EA026642B1 publication Critical patent/EA026642B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный ингредиент, выбранный из (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный ингредиент, который представляет собой компонент салициловой кислоты, выбранный из группы, состоящей из ацетилсалициловой кислоты, салициловой кислоты, салициламида, этензамида, салсалата, дипироцетила, бенорилата, дифлунизала, гуацетизала, и их физиологически приемлемых солей.
EA201401267A 2012-05-18 2013-05-16 Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и ацетилсалициловую кислоту EA026642B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003936 2012-05-18
PCT/EP2013/001467 WO2013170968A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component

Publications (2)

Publication Number Publication Date
EA201401267A1 true EA201401267A1 (ru) 2016-05-31
EA026642B1 EA026642B1 (ru) 2017-04-28

Family

ID=48468207

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401267A EA026642B1 (ru) 2012-05-18 2013-05-16 Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и ацетилсалициловую кислоту

Country Status (23)

Country Link
US (1) US9855286B2 (ru)
EP (1) EP2852386B1 (ru)
JP (1) JP6116675B2 (ru)
CN (1) CN104284661A (ru)
AU (1) AU2013262074B2 (ru)
BR (1) BR112014028564A2 (ru)
CA (1) CA2873640A1 (ru)
CY (1) CY1119692T1 (ru)
DK (1) DK2852386T3 (ru)
EA (1) EA026642B1 (ru)
ES (1) ES2654146T3 (ru)
HK (1) HK1204941A1 (ru)
HR (1) HRP20171927T1 (ru)
HU (1) HUE035930T2 (ru)
IL (1) IL235656B (ru)
LT (1) LT2852386T (ru)
MX (1) MX352595B (ru)
NO (1) NO2852386T3 (ru)
PL (1) PL2852386T3 (ru)
PT (1) PT2852386T (ru)
RS (1) RS56674B1 (ru)
SI (1) SI2852386T1 (ru)
WO (1) WO2013170968A1 (ru)

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* Cited by examiner, † Cited by third party
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DK3247352T3 (da) 2015-01-23 2020-09-07 Gruenenthal Gmbh Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion

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Also Published As

Publication number Publication date
LT2852386T (lt) 2018-01-10
RS56674B1 (sr) 2018-03-30
HK1204941A1 (en) 2015-12-11
DK2852386T3 (en) 2018-01-08
CA2873640A1 (en) 2013-11-21
JP6116675B2 (ja) 2017-04-19
IL235656A0 (en) 2015-01-29
MX2014012765A (es) 2014-11-21
NO2852386T3 (ru) 2018-04-14
PT2852386T (pt) 2018-01-04
EP2852386A1 (en) 2015-04-01
SI2852386T1 (en) 2018-04-30
ES2654146T3 (es) 2018-02-12
BR112014028564A2 (pt) 2017-06-27
EP2852386B1 (en) 2017-11-15
IL235656B (en) 2018-08-30
CN104284661A (zh) 2015-01-14
EA026642B1 (ru) 2017-04-28
WO2013170968A1 (en) 2013-11-21
PL2852386T3 (pl) 2018-02-28
JP2015516448A (ja) 2015-06-11
CY1119692T1 (el) 2018-04-04
US20130317076A1 (en) 2013-11-28
US9855286B2 (en) 2018-01-02
AU2013262074B2 (en) 2018-01-18
HUE035930T2 (hu) 2018-06-28
HRP20171927T1 (hr) 2018-01-26
MX352595B (es) 2017-11-30
AU2013262074A1 (en) 2015-01-22

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