EA201401267A1 - Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и компонент салициловой кислоты - Google Patents

Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и компонент салициловой кислоты

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Publication number
EA201401267A1
EA201401267A1 EA201401267A EA201401267A EA201401267A1 EA 201401267 A1 EA201401267 A1 EA 201401267A1 EA 201401267 A EA201401267 A EA 201401267A EA 201401267 A EA201401267 A EA 201401267A EA 201401267 A1 EA201401267 A1 EA 201401267A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salicylic acid
spiro
dihydro
fluoro
dimethyl
Prior art date
Application number
EA201401267A
Other languages
English (en)
Other versions
EA026642B1 (ru
Inventor
Штефани Фрош
Клаус Линц
Клаус Шине
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401267A1 publication Critical patent/EA201401267A1/ru
Publication of EA026642B1 publication Critical patent/EA026642B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный ингредиент, выбранный из (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный ингредиент, который представляет собой компонент салициловой кислоты, выбранный из группы, состоящей из ацетилсалициловой кислоты, салициловой кислоты, салициламида, этензамида, салсалата, дипироцетила, бенорилата, дифлунизала, гуацетизала, и их физиологически приемлемых солей.
EA201401267A 2012-05-18 2013-05-16 Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и ацетилсалициловую кислоту EA026642B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003936 2012-05-18
PCT/EP2013/001467 WO2013170968A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component

Publications (2)

Publication Number Publication Date
EA201401267A1 true EA201401267A1 (ru) 2016-05-31
EA026642B1 EA026642B1 (ru) 2017-04-28

Family

ID=48468207

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401267A EA026642B1 (ru) 2012-05-18 2013-05-16 Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и ацетилсалициловую кислоту

Country Status (23)

Country Link
US (1) US9855286B2 (ru)
EP (1) EP2852386B1 (ru)
JP (1) JP6116675B2 (ru)
CN (1) CN104284661A (ru)
AU (1) AU2013262074B2 (ru)
BR (1) BR112014028564A2 (ru)
CA (1) CA2873640A1 (ru)
CY (1) CY1119692T1 (ru)
DK (1) DK2852386T3 (ru)
EA (1) EA026642B1 (ru)
ES (1) ES2654146T3 (ru)
HK (1) HK1204941A1 (ru)
HR (1) HRP20171927T1 (ru)
HU (1) HUE035930T2 (ru)
IL (1) IL235656B (ru)
LT (1) LT2852386T (ru)
MX (1) MX352595B (ru)
NO (1) NO2852386T3 (ru)
PL (1) PL2852386T3 (ru)
PT (1) PT2852386T (ru)
RS (1) RS56674B1 (ru)
SI (1) SI2852386T1 (ru)
WO (1) WO2013170968A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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Also Published As

Publication number Publication date
IL235656B (en) 2018-08-30
WO2013170968A1 (en) 2013-11-21
CN104284661A (zh) 2015-01-14
PL2852386T3 (pl) 2018-02-28
IL235656A0 (en) 2015-01-29
MX352595B (es) 2017-11-30
HUE035930T2 (hu) 2018-06-28
NO2852386T3 (ru) 2018-04-14
CA2873640A1 (en) 2013-11-21
EP2852386A1 (en) 2015-04-01
LT2852386T (lt) 2018-01-10
JP2015516448A (ja) 2015-06-11
PT2852386T (pt) 2018-01-04
US9855286B2 (en) 2018-01-02
AU2013262074B2 (en) 2018-01-18
SI2852386T1 (en) 2018-04-30
JP6116675B2 (ja) 2017-04-19
US20130317076A1 (en) 2013-11-28
HK1204941A1 (en) 2015-12-11
RS56674B1 (sr) 2018-03-30
CY1119692T1 (el) 2018-04-04
AU2013262074A1 (en) 2015-01-22
HRP20171927T1 (hr) 2018-01-26
EP2852386B1 (en) 2017-11-15
MX2014012765A (es) 2014-11-21
EA026642B1 (ru) 2017-04-28
BR112014028564A2 (pt) 2017-06-27
DK2852386T3 (en) 2018-01-08
ES2654146T3 (es) 2018-02-12

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