MX356493B - Composicion farmaceutica que comprende (1r.4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexan-1,1´-pirano[3,4,b] indol]-4-amina y un nsar. - Google Patents

Composicion farmaceutica que comprende (1r.4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexan-1,1´-pirano[3,4,b] indol]-4-amina y un nsar.

Info

Publication number
MX356493B
MX356493B MX2014013028A MX2014013028A MX356493B MX 356493 B MX356493 B MX 356493B MX 2014013028 A MX2014013028 A MX 2014013028A MX 2014013028 A MX2014013028 A MX 2014013028A MX 356493 B MX356493 B MX 356493B
Authority
MX
Mexico
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
MX2014013028A
Other languages
English (en)
Other versions
MX2014013028A (es
Inventor
Linz Klaus
Schiene Klaus
Frosch Stefanie
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014013028A publication Critical patent/MX2014013028A/es
Publication of MX356493B publication Critical patent/MX356493B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con una composición farmacéutica que comprende un primer ingrediente farmacológicamente activo, seleccionado de (1R,4R)-6´-fluoro-N,N-d imetil-4-fenil-4´,9´-dihidro-3´H-espiro[ciclohexan-1,1´-pirano[3, 4-b]indol]-4-amina y las sales fisiológicamente aceptables del mismo, y un segundo ingrediente farmacológicamente activo, el cual es un fármaco antirreumático no esteroideo seleccionado del grupo que consiste de indometacina, diclofenaco, sulindaco, tolmetina, zomepiraco, aclofenaco, bumadizona, etolodaco, lonazolaco, fentiazaco, acemetacina, difenpiramida, oxamatacin, proglumetacina, keterolaco, aceclofenaco, bufexamaco, ácido mefenámico, ácido tolfenámico, ácido flufenámico, ácido meclofenámico y las sales fisiológicamente aceptables de los mismos. Figura 1.
MX2014013028A 2012-05-18 2013-05-16 Composicion farmaceutica que comprende (1r.4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexan-1,1´-pirano[3,4,b] indol]-4-amina y un nsar. MX356493B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003895 2012-05-18
PCT/EP2013/001470 WO2013170971A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar

Publications (2)

Publication Number Publication Date
MX2014013028A MX2014013028A (es) 2015-02-04
MX356493B true MX356493B (es) 2018-05-31

Family

ID=48520892

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013028A MX356493B (es) 2012-05-18 2013-05-16 Composicion farmaceutica que comprende (1r.4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexan-1,1´-pirano[3,4,b] indol]-4-amina y un nsar.

Country Status (22)

Country Link
US (1) US8912226B2 (es)
EP (1) EP2849747B1 (es)
JP (1) JP6116678B2 (es)
CN (1) CN104284660A (es)
AU (1) AU2013262077B2 (es)
BR (1) BR112014028566A2 (es)
CA (1) CA2873867A1 (es)
CY (1) CY1119781T1 (es)
DK (1) DK2849747T3 (es)
EA (1) EA027145B1 (es)
ES (1) ES2658217T3 (es)
HR (1) HRP20171725T1 (es)
HU (1) HUE034658T2 (es)
IL (1) IL235653B (es)
LT (1) LT2849747T (es)
MX (1) MX356493B (es)
NO (1) NO2849747T3 (es)
PL (1) PL2849747T3 (es)
PT (1) PT2849747T (es)
RS (1) RS56788B1 (es)
SI (1) SI2849747T1 (es)
WO (1) WO2013170971A1 (es)

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TW201642853A (zh) 2015-01-23 2016-12-16 歌林達有限公司 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ）
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
AU2017226830B2 (en) 2016-02-29 2021-06-24 Grünenthal GmbH Titration of cebranopadol

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Also Published As

Publication number Publication date
ES2658217T3 (es) 2018-03-08
IL235653B (en) 2018-08-30
EP2849747B1 (en) 2017-11-01
PT2849747T (pt) 2018-02-07
MX2014013028A (es) 2015-02-04
IL235653A0 (en) 2015-01-29
EA027145B1 (ru) 2017-06-30
AU2013262077B2 (en) 2017-10-26
US20130317075A1 (en) 2013-11-28
JP6116678B2 (ja) 2017-04-19
HUE034658T2 (hu) 2018-02-28
CY1119781T1 (el) 2018-06-27
EA201401270A1 (ru) 2016-05-31
NO2849747T3 (es) 2018-03-31
CA2873867A1 (en) 2013-11-21
EP2849747A1 (en) 2015-03-25
LT2849747T (lt) 2018-01-25
WO2013170971A1 (en) 2013-11-21
SI2849747T1 (en) 2018-04-30
DK2849747T3 (en) 2017-12-04
CN104284660A (zh) 2015-01-14
BR112014028566A2 (pt) 2017-06-27
JP2015516451A (ja) 2015-06-11
AU2013262077A1 (en) 2015-01-22
RS56788B1 (sr) 2018-04-30
HK1204938A1 (en) 2015-12-11
PL2849747T3 (pl) 2018-03-30
US8912226B2 (en) 2014-12-16
HRP20171725T1 (hr) 2017-12-29

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