CY1119825T1 - Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη - Google Patents

Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη

Info

Publication number
CY1119825T1
CY1119825T1 CY20181100091T CY181100091T CY1119825T1 CY 1119825 T1 CY1119825 T1 CY 1119825T1 CY 20181100091 T CY20181100091 T CY 20181100091T CY 181100091 T CY181100091 T CY 181100091T CY 1119825 T1 CY1119825 T1 CY 1119825T1
Authority
CY
Cyprus
Prior art keywords
spiro
dihydro
fluoro
dimethyl
amine
Prior art date
Application number
CY20181100091T
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Thomas Christoph
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1119825T1 publication Critical patent/CY1119825T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση αφορά σε φαρμακευτική σύνθεση που περιλαμβάνει πρώτο φαρμακολογικώς δραστικό συστατικό που επιλέγεται από (1r,4r-)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'H-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμίνη και τα φυσιολογικώς αποδεκτά άλατα αυτής και δεύτερο φαρμακολογικώς δραστικό συστατικό το οποίο είναι αντικαταθλιπτικό.
CY20181100091T 2012-05-18 2018-01-24 Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη CY1119825T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003937 2012-05-18
EP13723003.3A EP2849744B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and duloxetine
PCT/EP2013/001464 WO2013170965A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants

Publications (1)

Publication Number Publication Date
CY1119825T1 true CY1119825T1 (el) 2018-06-27

Family

ID=48446243

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100091T CY1119825T1 (el) 2012-05-18 2018-01-24 Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη

Country Status (23)

Country Link
US (2) US20130310385A1 (el)
EP (1) EP2849744B1 (el)
JP (1) JP6116672B2 (el)
CN (1) CN104271131A (el)
AU (1) AU2013262071B2 (el)
BR (1) BR112014028562A2 (el)
CA (1) CA2873634A1 (el)
CY (1) CY1119825T1 (el)
DK (1) DK2849744T3 (el)
EA (1) EA027268B1 (el)
ES (1) ES2660461T3 (el)
HK (1) HK1204944A1 (el)
HR (1) HRP20171922T1 (el)
HU (1) HUE037746T2 (el)
IL (1) IL235657B (el)
LT (1) LT2849744T (el)
MX (1) MX354684B (el)
NO (1) NO2849744T3 (el)
PL (1) PL2849744T3 (el)
PT (1) PT2849744T (el)
RS (1) RS56856B1 (el)
SI (1) SI2849744T1 (el)
WO (1) WO2013170965A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201642853A (zh) 2015-01-23 2016-12-16 歌林達有限公司 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ）

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Also Published As

Publication number Publication date
US20170065560A1 (en) 2017-03-09
EA027268B1 (ru) 2017-07-31
CA2873634A1 (en) 2013-11-21
HK1204944A1 (en) 2015-12-11
EP2849744A1 (en) 2015-03-25
US20130310385A1 (en) 2013-11-21
LT2849744T (lt) 2018-02-26
MX354684B (es) 2018-03-15
AU2013262071B2 (en) 2018-01-18
WO2013170965A1 (en) 2013-11-21
DK2849744T3 (en) 2018-01-22
SI2849744T1 (en) 2018-01-31
AU2013262071A1 (en) 2015-01-22
PT2849744T (pt) 2018-02-28
PL2849744T3 (pl) 2018-06-29
JP6116672B2 (ja) 2017-04-19
HRP20171922T1 (hr) 2018-02-09
IL235657B (en) 2018-08-30
NO2849744T3 (el) 2018-04-21
RS56856B1 (sr) 2018-04-30
MX2014012859A (es) 2015-01-19
US10328055B2 (en) 2019-06-25
HUE037746T2 (hu) 2018-09-28
IL235657A0 (en) 2015-01-29
EP2849744B1 (en) 2017-11-22
JP2015520154A (ja) 2015-07-16
ES2660461T3 (es) 2018-03-22
CN104271131A (zh) 2015-01-07
EA201401269A1 (ru) 2016-05-31
BR112014028562A2 (pt) 2017-06-27

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