CY1120525T1 - Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη - Google Patents

Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη

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Publication number
CY1120525T1
CY1120525T1 CY20171100830T CY171100830T CY1120525T1 CY 1120525 T1 CY1120525 T1 CY 1120525T1 CY 20171100830 T CY20171100830 T CY 20171100830T CY 171100830 T CY171100830 T CY 171100830T CY 1120525 T1 CY1120525 T1 CY 1120525T1
Authority
CY
Cyprus
Prior art keywords
pyrano
spiro
fluoro
dimethyl
phenyl
Prior art date
Application number
CY20171100830T
Other languages
English (en)
Inventor
Michael Gruss
Stefan Kluge
Stefan PRÜHS
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1120525T1 publication Critical patent/CY1120525T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε κρυσταλλικές μορφές της (1r,4r)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3Ή-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,b]ινδολ]-4-αμίνης, φαρμακευτικές συνθέσεις και φάρμακα τα οποία περιέχουν αυτές τις τροποποιήσεις, στη χρήση αυτών των τροποποιήσεων καθώς και σε μια μέθοδο για τον εμπλουτισμό τους.
CY20171100830T 2011-07-08 2017-08-02 Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη CY1120525T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
EP12748646.2A EP2729470B1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
CY1120525T1 true CY1120525T1 (el) 2019-07-10

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100830T CY1120525T1 (el) 2011-07-08 2017-08-02 Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη

Country Status (23)

Country Link
US (2) US8618156B2 (el)
EP (2) EP2729470B1 (el)
JP (2) JP6276689B2 (el)
CN (2) CN103649094B (el)
AR (1) AR087081A1 (el)
AU (2) AU2012283449B2 (el)
BR (1) BR112014000358A2 (el)
CA (1) CA2841032C (el)
CY (1) CY1120525T1 (el)
DK (2) DK3235821T3 (el)
EA (1) EA026750B1 (el)
ES (1) ES2641299T3 (el)
HR (1) HRP20170968T1 (el)
HU (1) HUE033043T2 (el)
IL (1) IL230331B (el)
LT (1) LT2729470T (el)
MX (1) MX2014000297A (el)
PL (1) PL2729470T3 (el)
PT (1) PT2729470T (el)
RS (1) RS56343B1 (el)
SI (1) SI2729470T1 (el)
TW (1) TWI585092B (el)
WO (1) WO2013007361A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2729470B1 (en) * 2011-07-08 2017-06-21 Grünenthal GmbH Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
US10022353B2 (en) * 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
US20180021304A1 (en) 2015-02-02 2018-01-25 Ratiopharm Gmbh Composition comprising cebranopadol in a dissolved form
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定
WO2020233588A1 (zh) * 2019-05-21 2020-11-26 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
RS58017B1 (sr) * 2010-08-04 2019-02-28 Gruenenthal Gmbh Farmaceutska dozna forma koja sadrži 6'-fluoro-(n-metil- ili n,n-dimetil-)-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za lečenje nociceptivnog bola
EP2729470B1 (en) * 2011-07-08 2017-06-21 Grünenthal GmbH Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
CN106939005A (zh) 2017-07-11
HUE033043T2 (hu) 2017-11-28
JP6559165B2 (ja) 2019-08-14
AU2012283449B2 (en) 2017-04-06
JP2017081981A (ja) 2017-05-18
EP3235821B1 (en) 2020-04-08
EP2729470A1 (en) 2014-05-14
BR112014000358A2 (pt) 2017-01-10
PT2729470T (pt) 2017-10-02
DK2729470T3 (en) 2017-09-11
JP2014518226A (ja) 2014-07-28
RS56343B1 (sr) 2017-12-29
EP3235821A1 (en) 2017-10-25
SI2729470T1 (sl) 2017-10-30
CN103649094B (zh) 2017-05-24
TWI585092B (zh) 2017-06-01
IL230331B (en) 2018-11-29
CN103649094A (zh) 2014-03-19
US8618156B2 (en) 2013-12-31
ES2641299T3 (es) 2017-11-08
AU2012283449A8 (en) 2014-03-27
EP2729470B1 (en) 2017-06-21
HRP20170968T1 (hr) 2017-09-22
US8765800B2 (en) 2014-07-01
US20130012563A1 (en) 2013-01-10
LT2729470T (lt) 2017-08-25
AU2012283449A1 (en) 2014-02-20
DK3235821T3 (da) 2020-04-20
AU2017204572B2 (en) 2018-05-24
PL2729470T3 (pl) 2017-11-30
MX2014000297A (es) 2014-01-31
US20130231381A1 (en) 2013-09-05
WO2013007361A1 (en) 2013-01-17
EA201400120A1 (ru) 2014-06-30
EA026750B1 (ru) 2017-05-31
JP6276689B2 (ja) 2018-02-07
AU2017204572A1 (en) 2017-07-27
TW201311694A (zh) 2013-03-16
WO2013007361A9 (en) 2013-12-27
AR087081A1 (es) 2014-02-12
CA2841032A1 (en) 2013-01-17
WO2013007361A8 (en) 2013-04-04
CA2841032C (en) 2020-12-15

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