BR112014014168A2 - processo para a preparação de (1r,4r)-6'-fluoro-(n,n-dimetil e n-metil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-amina - Google Patents
processo para a preparação de (1r,4r)-6'-fluoro-(n,n-dimetil e n-metil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-aminaInfo
- Publication number
- BR112014014168A2 BR112014014168A2 BR112014014168A BR112014014168A BR112014014168A2 BR 112014014168 A2 BR112014014168 A2 BR 112014014168A2 BR 112014014168 A BR112014014168 A BR 112014014168A BR 112014014168 A BR112014014168 A BR 112014014168A BR 112014014168 A2 BR112014014168 A2 BR 112014014168A2
- Authority
- BR
- Brazil
- Prior art keywords
- spiro
- dihydro
- cyclohexane
- fluoro
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
resumo processo para a preparação de (1r,4r)-6'-fluoro-(n,n-dimetil e n-metil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-amina. a presente invenção refere-se a um processo para a preparação de (1r,4r)-6-fluoro-n,n-dimetil-4-fenil-4,9-dihidro-3h-espiro[ciclohexano-1,1-pirano[3,4b]indol]-4-amina e (1r,4r)-6-fluoro-n-metil-4-fenil-4,9-dihidro-3h-espiro[ciclohexano-1,1-pirano[3,4b]indol]-4-amina ou sais de adição de ácido fisiologicamente aceitáveis?? dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11009765 | 2011-12-12 | ||
PCT/EP2012/075002 WO2013087589A1 (en) | 2011-12-12 | 2012-12-11 | Process for the preparation of (1r,4r)-6'-fluoro-(n,n-dimethyl- and n-methyl)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014014168A2 true BR112014014168A2 (pt) | 2017-06-13 |
Family
ID=47429786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014014168A BR112014014168A2 (pt) | 2011-12-12 | 2012-12-11 | processo para a preparação de (1r,4r)-6'-fluoro-(n,n-dimetil e n-metil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-amina |
Country Status (13)
Country | Link |
---|---|
US (1) | US8779160B2 (pt) |
EP (1) | EP2797925B1 (pt) |
CN (1) | CN104159902B (pt) |
BR (1) | BR112014014168A2 (pt) |
ES (1) | ES2577861T3 (pt) |
HK (1) | HK1199257A1 (pt) |
HU (1) | HUE029070T2 (pt) |
IL (1) | IL233047A (pt) |
MX (1) | MX359343B (pt) |
PL (1) | PL2797925T3 (pt) |
PT (1) | PT2797925T (pt) |
SI (1) | SI2797925T1 (pt) |
WO (1) | WO2013087589A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018004175A (es) | 2015-10-15 | 2018-06-06 | Jiangsu Hengrui Medicine Co | Derivado oxa espiro, su metodo de preparacion, y sus aplicaciones en medicinas. |
WO2024129782A1 (en) | 2022-12-12 | 2024-06-20 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
WO2024173714A1 (en) | 2023-02-15 | 2024-08-22 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
DE102007009319A1 (de) * | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
US8614245B2 (en) * | 2011-07-08 | 2013-12-24 | Gruenenthal Gmbh | Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine |
-
2012
- 2012-12-11 MX MX2014006943A patent/MX359343B/es active IP Right Grant
- 2012-12-11 EP EP12806004.3A patent/EP2797925B1/en active Active
- 2012-12-11 BR BR112014014168A patent/BR112014014168A2/pt not_active Application Discontinuation
- 2012-12-11 PT PT128060043T patent/PT2797925T/pt unknown
- 2012-12-11 CN CN201280061189.4A patent/CN104159902B/zh not_active Expired - Fee Related
- 2012-12-11 ES ES12806004.3T patent/ES2577861T3/es active Active
- 2012-12-11 SI SI201230608A patent/SI2797925T1/sl unknown
- 2012-12-11 US US13/711,455 patent/US8779160B2/en active Active
- 2012-12-11 HU HUE12806004A patent/HUE029070T2/en unknown
- 2012-12-11 PL PL12806004T patent/PL2797925T3/pl unknown
- 2012-12-11 WO PCT/EP2012/075002 patent/WO2013087589A1/en active Application Filing
-
2014
- 2014-06-10 IL IL233047A patent/IL233047A/en active IP Right Grant
- 2014-12-23 HK HK14112858.0A patent/HK1199257A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL2797925T3 (pl) | 2016-07-29 |
HUE029070T2 (en) | 2017-02-28 |
MX2014006943A (es) | 2015-01-26 |
EP2797925B1 (en) | 2016-03-23 |
WO2013087589A1 (en) | 2013-06-20 |
US8779160B2 (en) | 2014-07-15 |
EP2797925A1 (en) | 2014-11-05 |
HK1199257A1 (zh) | 2015-06-26 |
IL233047A (en) | 2016-06-30 |
CN104159902A (zh) | 2014-11-19 |
MX359343B (es) | 2018-09-26 |
PT2797925T (pt) | 2016-07-07 |
ES2577861T3 (es) | 2016-07-19 |
IL233047A0 (en) | 2014-07-31 |
US20130150590A1 (en) | 2013-06-13 |
CN104159902B (zh) | 2016-05-04 |
SI2797925T1 (sl) | 2016-07-29 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |