MX359343B - Proceso para la preparación de (1r,4r)-6´-fluoro-(n,n-dimetil- y n-metil)-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano -[3,4,b]indol]-4-amina. - Google Patents

Proceso para la preparación de (1r,4r)-6´-fluoro-(n,n-dimetil- y n-metil)-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano -[3,4,b]indol]-4-amina.

Info

Publication number
MX359343B
MX359343B MX2014006943A MX2014006943A MX359343B MX 359343 B MX359343 B MX 359343B MX 2014006943 A MX2014006943 A MX 2014006943A MX 2014006943 A MX2014006943 A MX 2014006943A MX 359343 B MX359343 B MX 359343B
Authority
MX
Mexico
Prior art keywords
pyrano
indol
spiro
dihydro
fluoro
Prior art date
Application number
MX2014006943A
Other languages
English (en)
Other versions
MX2014006943A (es
Inventor
Hell Wolfgang
Prühs Stefan
Griebel Carsten
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014006943A publication Critical patent/MX2014006943A/es
Publication of MX359343B publication Critical patent/MX359343B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de (1r,4r)-6´-fluoro-N,N-dimeitl-4-fenil-4´-,9´-di-hidro-3´H-espir o [ciclohexano-1,1´ pirano [3,4b]-indol]-4-amina y (1r, 4r)-6´-fluoro-N-metil-4-fenil-4´,9´-dihidro-3´H-espiro [ciclohexano-1,1´-pirano [3,4b]-indol]-4-amina o sales de adición de ácido fisiológicamente aceptables de las mismas.
MX2014006943A 2011-12-12 2012-12-11 Proceso para la preparación de (1r,4r)-6´-fluoro-(n,n-dimetil- y n-metil)-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano -[3,4,b]indol]-4-amina. MX359343B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11009765 2011-12-12
PCT/EP2012/075002 WO2013087589A1 (en) 2011-12-12 2012-12-11 Process for the preparation of (1r,4r)-6'-fluoro-(n,n-dimethyl- and n-methyl)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine

Publications (2)

Publication Number Publication Date
MX2014006943A MX2014006943A (es) 2015-01-26
MX359343B true MX359343B (es) 2018-09-26

Family

ID=47429786

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006943A MX359343B (es) 2011-12-12 2012-12-11 Proceso para la preparación de (1r,4r)-6´-fluoro-(n,n-dimetil- y n-metil)-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano -[3,4,b]indol]-4-amina.

Country Status (13)

Country Link
US (1) US8779160B2 (es)
EP (1) EP2797925B1 (es)
CN (1) CN104159902B (es)
BR (1) BR112014014168A2 (es)
ES (1) ES2577861T3 (es)
HK (1) HK1199257A1 (es)
HU (1) HUE029070T2 (es)
IL (1) IL233047A (es)
MX (1) MX359343B (es)
PL (1) PL2797925T3 (es)
PT (1) PT2797925T (es)
SI (1) SI2797925T1 (es)
WO (1) WO2013087589A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018004175A (es) 2015-10-15 2018-06-06 Jiangsu Hengrui Medicine Co Derivado oxa espiro, su metodo de preparacion, y sus aplicaciones en medicinas.
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2024173714A1 (en) 2023-02-15 2024-08-22 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009319A1 (de) * 2007-02-22 2008-08-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8614245B2 (en) * 2011-07-08 2013-12-24 Gruenenthal Gmbh Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
PL2797925T3 (pl) 2016-07-29
HUE029070T2 (en) 2017-02-28
MX2014006943A (es) 2015-01-26
EP2797925B1 (en) 2016-03-23
BR112014014168A2 (pt) 2017-06-13
WO2013087589A1 (en) 2013-06-20
US8779160B2 (en) 2014-07-15
EP2797925A1 (en) 2014-11-05
HK1199257A1 (zh) 2015-06-26
IL233047A (en) 2016-06-30
CN104159902A (zh) 2014-11-19
PT2797925T (pt) 2016-07-07
ES2577861T3 (es) 2016-07-19
IL233047A0 (en) 2014-07-31
US20130150590A1 (en) 2013-06-13
CN104159902B (zh) 2016-05-04
SI2797925T1 (sl) 2016-07-29

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