HK1199257A1 - '- '- '- 製備 '-氟代- -二甲基-和 -甲基 -苯基- '， '-二氫- -螺環 環己烷- '-吡喃並- 吲哚基 -胺的方法 - Google Patents

'- '- '- 製備 '-氟代- -二甲基-和 -甲基 -苯基- '， '-二氫- -螺環 環己烷- '-吡喃並- 吲哚基 -胺的方法

Info

Publication number
HK1199257A1
HK1199257A1 HK14112858.0A HK14112858A HK1199257A1 HK 1199257 A1 HK1199257 A1 HK 1199257A1 HK 14112858 A HK14112858 A HK 14112858A HK 1199257 A1 HK1199257 A1 HK 1199257A1
Authority
HK
Hong Kong
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
HK14112858.0A
Other languages
English (en)
Inventor
Stefan Prhs
Carsten Griebel
Wolfgang Hell
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HK1199257A1 publication Critical patent/HK1199257A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK14112858.0A 2011-12-12 2014-12-23 '- '- '- 製備 '-氟代- -二甲基-和 -甲基 -苯基- '， '-二氫- -螺環 環己烷- '-吡喃並- 吲哚基 -胺的方法 HK1199257A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11009765 2011-12-12
PCT/EP2012/075002 WO2013087589A1 (en) 2011-12-12 2012-12-11 Process for the preparation of (1r,4r)-6'-fluoro-(n,n-dimethyl- and n-methyl)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine
EP12806004.3A EP2797925B1 (en) 2011-12-12 2012-12-11 Process for the preparation of (1r,4r)-6'-fluoro-(n,n-dimethyl- and n-methyl)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
HK1199257A1 true HK1199257A1 (zh) 2015-06-26

Family

ID=47429786

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112858.0A HK1199257A1 (zh) 2011-12-12 2014-12-23 '- '- '- 製備 '-氟代- -二甲基-和 -甲基 -苯基- '， '-二氫- -螺環 環己烷- '-吡喃並- 吲哚基 -胺的方法

Country Status (13)

Country Link
US (1) US8779160B2 (zh)
EP (1) EP2797925B1 (zh)
CN (1) CN104159902B (zh)
BR (1) BR112014014168A2 (zh)
ES (1) ES2577861T3 (zh)
HK (1) HK1199257A1 (zh)
HU (1) HUE029070T2 (zh)
IL (1) IL233047A (zh)
MX (1) MX359343B (zh)
PL (1) PL2797925T3 (zh)
PT (1) PT2797925T (zh)
SI (1) SI2797925T1 (zh)
WO (1) WO2013087589A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001347B (zh) 2015-10-15 2019-09-24 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009319A1 (de) * 2007-02-22 2008-08-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8614245B2 (en) * 2011-07-08 2013-12-24 Gruenenthal Gmbh Crystalline (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
CN104159902B (zh) 2016-05-04
CN104159902A (zh) 2014-11-19
US20130150590A1 (en) 2013-06-13
EP2797925A1 (en) 2014-11-05
EP2797925B1 (en) 2016-03-23
IL233047A (en) 2016-06-30
PT2797925T (pt) 2016-07-07
BR112014014168A2 (pt) 2017-06-13
PL2797925T3 (pl) 2016-07-29
US8779160B2 (en) 2014-07-15
SI2797925T1 (sl) 2016-07-29
ES2577861T3 (es) 2016-07-19
MX2014006943A (es) 2015-01-26
IL233047A0 (en) 2014-07-31
WO2013087589A1 (en) 2013-06-20
HUE029070T2 (en) 2017-02-28
MX359343B (es) 2018-09-26

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20201214