RS56343B1 - Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin - Google Patents

Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin

Info

Publication number
RS56343B1
RS56343B1 RS20170921A RSP20170921A RS56343B1 RS 56343 B1 RS56343 B1 RS 56343B1 RS 20170921 A RS20170921 A RS 20170921A RS P20170921 A RSP20170921 A RS P20170921A RS 56343 B1 RS56343 B1 RS 56343B1
Authority
RS
Serbia
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
RS20170921A
Other languages
English (en)
Inventor
Michael Gruss
Stefan Kluge
Stefan Prühs
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of RS56343B1 publication Critical patent/RS56343B1/sr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
RS20170921A 2011-07-08 2012-07-06 Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin RS56343B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
EP12748646.2A EP2729470B1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
RS56343B1 true RS56343B1 (sr) 2017-12-29

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20170921A RS56343B1 (sr) 2011-07-08 2012-07-06 Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin

Country Status (23)

Country Link
US (2) US8618156B2 (sr)
EP (2) EP2729470B1 (sr)
JP (2) JP6276689B2 (sr)
CN (2) CN106939005A (sr)
AR (1) AR087081A1 (sr)
AU (2) AU2012283449B2 (sr)
BR (1) BR112014000358A2 (sr)
CA (1) CA2841032C (sr)
CY (1) CY1120525T1 (sr)
DK (2) DK2729470T3 (sr)
EA (1) EA026750B1 (sr)
ES (1) ES2641299T3 (sr)
HR (1) HRP20170968T1 (sr)
HU (1) HUE033043T2 (sr)
IL (1) IL230331B (sr)
LT (1) LT2729470T (sr)
MX (1) MX2014000297A (sr)
PL (1) PL2729470T3 (sr)
PT (1) PT2729470T (sr)
RS (1) RS56343B1 (sr)
SI (1) SI2729470T1 (sr)
TW (1) TWI585092B (sr)
WO (1) WO2013007361A1 (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および/または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール
WO2016124513A1 (en) 2015-02-02 2016-08-11 Ratiopharm Gmbh Composition comprising cebranopadol in a dissolved form
EP3423054A1 (en) 2016-02-29 2019-01-09 Grünenthal GmbH Titration of cebranopadol
JP7365073B2 (ja) * 2019-05-21 2023-10-19 ジァンスー フォアフロント ファーマシューティカル カンパニー,リミテッド トレプロスチニルナトリウムの新規な結晶形および製造方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2024173714A1 (en) 2023-02-15 2024-08-22 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CA2805523C (en) * 2010-08-04 2018-06-12 Gruenenthal Gmbh Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
US20130012563A1 (en) 2013-01-10
AU2017204572B2 (en) 2018-05-24
CA2841032A1 (en) 2013-01-17
AU2012283449A1 (en) 2014-02-20
JP6559165B2 (ja) 2019-08-14
PT2729470T (pt) 2017-10-02
EA201400120A1 (ru) 2014-06-30
HRP20170968T1 (hr) 2017-09-22
CN106939005A (zh) 2017-07-11
SI2729470T1 (sl) 2017-10-30
JP2017081981A (ja) 2017-05-18
TW201311694A (zh) 2013-03-16
WO2013007361A1 (en) 2013-01-17
PL2729470T3 (pl) 2017-11-30
LT2729470T (lt) 2017-08-25
AR087081A1 (es) 2014-02-12
EP2729470A1 (en) 2014-05-14
CA2841032C (en) 2020-12-15
JP2014518226A (ja) 2014-07-28
DK3235821T3 (da) 2020-04-20
ES2641299T3 (es) 2017-11-08
EA026750B1 (ru) 2017-05-31
CY1120525T1 (el) 2019-07-10
EP3235821B1 (en) 2020-04-08
MX2014000297A (es) 2014-01-31
AU2017204572A1 (en) 2017-07-27
TWI585092B (zh) 2017-06-01
JP6276689B2 (ja) 2018-02-07
US20130231381A1 (en) 2013-09-05
WO2013007361A8 (en) 2013-04-04
IL230331B (en) 2018-11-29
CN103649094B (zh) 2017-05-24
AU2012283449B2 (en) 2017-04-06
AU2012283449A8 (en) 2014-03-27
EP2729470B1 (en) 2017-06-21
WO2013007361A9 (en) 2013-12-27
DK2729470T3 (en) 2017-09-11
EP3235821A1 (en) 2017-10-25
US8765800B2 (en) 2014-07-01
US8618156B2 (en) 2013-12-31
CN103649094A (zh) 2014-03-19
BR112014000358A2 (pt) 2017-01-10
HUE033043T2 (hu) 2017-11-28

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HRP20170968T1 (hr) Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin
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