LT2729470T - Kristalinis (1r,4r)-6`-fluor-n,n-dimetil-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas - Google Patents

Kristalinis (1r,4r)-6`-fluor-n,n-dimetil-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas

Info

Publication number
LT2729470T
LT2729470T LTEP12748646.2T LT12748646T LT2729470T LT 2729470 T LT2729470 T LT 2729470T LT 12748646 T LT12748646 T LT 12748646T LT 2729470 T LT2729470 T LT 2729470T
Authority
LT
Lithuania
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
LTEP12748646.2T
Other languages
English (en)
Inventor
Michael Gruss
Stefan Kluge
Stefan PRÜHS
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of LT2729470T publication Critical patent/LT2729470T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
LTEP12748646.2T 2011-07-08 2012-07-06 Kristalinis (1r,4r)-6`-fluor-n,n-dimetil-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas LT2729470T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
LT2729470T true LT2729470T (lt) 2017-08-25

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12748646.2T LT2729470T (lt) 2011-07-08 2012-07-06 Kristalinis (1r,4r)-6`-fluor-n,n-dimetil-4-fenil-4`,9`-dihidro-3`h-spiro[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas

Country Status (23)

Country Link
US (2) US8618156B2 (lt)
EP (2) EP3235821B1 (lt)
JP (2) JP6276689B2 (lt)
CN (2) CN103649094B (lt)
AR (1) AR087081A1 (lt)
AU (2) AU2012283449B2 (lt)
BR (1) BR112014000358A2 (lt)
CA (1) CA2841032C (lt)
CY (1) CY1120525T1 (lt)
DK (2) DK2729470T3 (lt)
EA (1) EA026750B1 (lt)
ES (1) ES2641299T3 (lt)
HR (1) HRP20170968T1 (lt)
HU (1) HUE033043T2 (lt)
IL (1) IL230331B (lt)
LT (1) LT2729470T (lt)
MX (1) MX2014000297A (lt)
PL (1) PL2729470T3 (lt)
PT (1) PT2729470T (lt)
RS (1) RS56343B1 (lt)
SI (1) SI2729470T1 (lt)
TW (1) TWI585092B (lt)
WO (1) WO2013007361A1 (lt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2729470T3 (en) * 2011-07-08 2017-09-11 Gruenenthal Gmbh Crystalline (1r, 4r) -6'-fluoro-n, n-dimethyl-4-phenyl-4 ', 9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyran [3,4, b ] indole] -4-amine
TW201642853A (zh) 2015-01-23 2016-12-16 歌林達有限公司 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ）
EP3253374B1 (en) 2015-02-02 2018-11-28 ratiopharm GmbH Composition comprising cebranopadol in a dissolved form
AU2017226830B2 (en) 2016-02-29 2021-06-24 Grünenthal GmbH Titration of cebranopadol
CA3141164C (en) * 2019-05-21 2023-09-05 Jiangsu Forefront Pharmaceutical Co., Ltd. New crystal form of treprostinil sodium salt and preparation method therefor
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
KR20250145673A (ko) 2023-02-15 2025-10-13 애드뉴리스 테라퓨틱스 인코포레이티드 통증 완화에 유용한 요법 및 조성물
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
SI2600851T1 (en) * 2010-08-04 2018-07-31 Gruenenthal Gmbh PHARMACEUTICAL FORM OF DOSAGE COVERING 6'-FLUORO- (N-METHYLLINE N, N-DIMETHYL-4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO- (CYCLOHEXANE-1,1'- PIRANO (3,4, B) INDOL) -4-AMIN, FOR NON-PROPHETIC DISEASE TREATMENT
DK2729470T3 (en) * 2011-07-08 2017-09-11 Gruenenthal Gmbh Crystalline (1r, 4r) -6'-fluoro-n, n-dimethyl-4-phenyl-4 ', 9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyran [3,4, b ] indole] -4-amine

Also Published As

Publication number Publication date
DK3235821T3 (da) 2020-04-20
JP2017081981A (ja) 2017-05-18
ES2641299T3 (es) 2017-11-08
AU2012283449A1 (en) 2014-02-20
RS56343B1 (sr) 2017-12-29
PT2729470T (pt) 2017-10-02
HRP20170968T1 (hr) 2017-09-22
AU2012283449B2 (en) 2017-04-06
WO2013007361A1 (en) 2013-01-17
JP6276689B2 (ja) 2018-02-07
EA201400120A1 (ru) 2014-06-30
HUE033043T2 (hu) 2017-11-28
US8765800B2 (en) 2014-07-01
EP3235821B1 (en) 2020-04-08
JP2014518226A (ja) 2014-07-28
US20130231381A1 (en) 2013-09-05
AU2017204572A1 (en) 2017-07-27
AU2017204572B2 (en) 2018-05-24
US8618156B2 (en) 2013-12-31
CN103649094A (zh) 2014-03-19
TWI585092B (zh) 2017-06-01
PL2729470T3 (pl) 2017-11-30
CA2841032C (en) 2020-12-15
AU2012283449A8 (en) 2014-03-27
EP3235821A1 (en) 2017-10-25
DK2729470T3 (en) 2017-09-11
EP2729470B1 (en) 2017-06-21
WO2013007361A8 (en) 2013-04-04
AR087081A1 (es) 2014-02-12
SI2729470T1 (sl) 2017-10-30
CN103649094B (zh) 2017-05-24
WO2013007361A9 (en) 2013-12-27
EA026750B1 (ru) 2017-05-31
US20130012563A1 (en) 2013-01-10
JP6559165B2 (ja) 2019-08-14
BR112014000358A2 (pt) 2017-01-10
CY1120525T1 (el) 2019-07-10
MX2014000297A (es) 2014-01-31
CA2841032A1 (en) 2013-01-17
TW201311694A (zh) 2013-03-16
EP2729470A1 (en) 2014-05-14
IL230331B (en) 2018-11-29
CN106939005A (zh) 2017-07-11

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