LT2849744T - Farmacinė kompozicija, apimanti (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-aminą ir duloksetiną - Google Patents

Farmacinė kompozicija, apimanti (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-aminą ir duloksetiną

Info

Publication number
LT2849744T
LT2849744T LTEP13723003.3T LT13723003T LT2849744T LT 2849744 T LT2849744 T LT 2849744T LT 13723003 T LT13723003 T LT 13723003T LT 2849744 T LT2849744 T LT 2849744T
Authority
LT
Lithuania
Prior art keywords
pyrano
duloxetine
indol
spiro
dihydro
Prior art date
Application number
LTEP13723003.3T
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Thomas Christoph
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of LT2849744T publication Critical patent/LT2849744T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTEP13723003.3T 2012-05-18 2013-05-16 Farmacinė kompozicija, apimanti (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-aminą ir duloksetiną LT2849744T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003937 2012-05-18
PCT/EP2013/001464 WO2013170965A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants

Publications (1)

Publication Number Publication Date
LT2849744T true LT2849744T (lt) 2018-02-26

Family

ID=48446243

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13723003.3T LT2849744T (lt) 2012-05-18 2013-05-16 Farmacinė kompozicija, apimanti (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-aminą ir duloksetiną

Country Status (23)

Country Link
US (2) US20130310385A1 (lt)
EP (1) EP2849744B1 (lt)
JP (1) JP6116672B2 (lt)
CN (1) CN104271131A (lt)
AU (1) AU2013262071B2 (lt)
BR (1) BR112014028562A2 (lt)
CA (1) CA2873634A1 (lt)
CY (1) CY1119825T1 (lt)
DK (1) DK2849744T3 (lt)
EA (1) EA027268B1 (lt)
ES (1) ES2660461T3 (lt)
HK (1) HK1204944A1 (lt)
HR (1) HRP20171922T1 (lt)
HU (1) HUE037746T2 (lt)
IL (1) IL235657B (lt)
LT (1) LT2849744T (lt)
MX (1) MX354684B (lt)
NO (1) NO2849744T3 (lt)
PL (1) PL2849744T3 (lt)
PT (1) PT2849744T (lt)
RS (1) RS56856B1 (lt)
SI (1) SI2849744T1 (lt)
WO (1) WO2013170965A1 (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016208779B2 (en) 2015-01-23 2020-11-12 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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Also Published As

Publication number Publication date
HK1204944A1 (en) 2015-12-11
WO2013170965A1 (en) 2013-11-21
HUE037746T2 (hu) 2018-09-28
US20170065560A1 (en) 2017-03-09
ES2660461T3 (es) 2018-03-22
JP2015520154A (ja) 2015-07-16
EP2849744A1 (en) 2015-03-25
US10328055B2 (en) 2019-06-25
SI2849744T1 (en) 2018-01-31
EP2849744B1 (en) 2017-11-22
BR112014028562A2 (pt) 2017-06-27
PL2849744T3 (pl) 2018-06-29
MX2014012859A (es) 2015-01-19
MX354684B (es) 2018-03-15
CN104271131A (zh) 2015-01-07
IL235657B (en) 2018-08-30
HRP20171922T1 (hr) 2018-02-09
AU2013262071A1 (en) 2015-01-22
CY1119825T1 (el) 2018-06-27
DK2849744T3 (en) 2018-01-22
IL235657A0 (en) 2015-01-29
CA2873634A1 (en) 2013-11-21
EA201401269A1 (ru) 2016-05-31
US20130310385A1 (en) 2013-11-21
EA027268B1 (ru) 2017-07-31
NO2849744T3 (lt) 2018-04-21
AU2013262071B2 (en) 2018-01-18
JP6116672B2 (ja) 2017-04-19
PT2849744T (pt) 2018-02-28
RS56856B1 (sr) 2018-04-30

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