HRP20171922T1 - Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-amin i duloksetin - Google Patents
Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-amin i duloksetin Download PDFInfo
- Publication number
- HRP20171922T1 HRP20171922T1 HRP20171922TT HRP20171922T HRP20171922T1 HR P20171922 T1 HRP20171922 T1 HR P20171922T1 HR P20171922T T HRP20171922T T HR P20171922TT HR P20171922 T HRP20171922 T HR P20171922T HR P20171922 T1 HRP20171922 T1 HR P20171922T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmacologically active
- pain
- active ingredient
- dosage form
- pharmaceutical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title claims 2
- 229960002866 duloxetine Drugs 0.000 title claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000002831 pharmacologic agent Substances 0.000 claims 10
- 208000002193 Pain Diseases 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 206010006002 Bone pain Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001107 psychogenic effect Effects 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (10)
1. Farmaceutski pripravak naznačen time da sadrži:
a) prvi farmakološki aktivni sastojak, koji je izabran od spoja prema kemijskoj formuli (I) i njegove fiziološki prihvatljive soli
[image]
i
b) drugi farmakološki aktivni sastojak koji je odabran iz skupine koja sadrži duloksetin i njegove fiziološki prihvatljive soli.
2. Farmaceutski pripravak prema zahtjevu 1, naznačen time da je prvi farmakološki aktivni sastojak spoj prema kemijskoj formuli (I)
[image]
3. Farmaceutski pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da sadrži prvi i drugi farmakološki aktivni sastojak u takvom masenom omjeru da će oni nakon davanja pacijentu imati sinergističko terapeutsko djelovanje.
4. Farmaceutski pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da je relativni omjer mase prvog farmakološki aktivnog sastojka prema drugom farmakološki aktivnom sastojku unutar raspona od 1 : 1 do 1 : 1,000,000.
5. Farmaceutski pripravak prema bilo kojem od prethodnih zahtjeva naznačen time da je za uporabu za sprječavanje ili liječenje boli.
6. Farmaceutski pripravak prema zahtjevu5, naznačen time da bol je:
- periferna, središnja ili mišićna skeletna bol; i/ili
- akutna, subakutna ili kronična bol; i/ili
- umjerena do jaka bol; i/ili
- neuropatska ili psihogena ili nociceptivna ili miješana bol; i/ili
- bol u donjem dijelu leđa, visceralna bol ili glavobolja; i/ili
- postoperativna (post-kirurška) bol, rak ili upalna bol.
7. Farmaceutski oblik doziranja naznačen time da sadrži farmaceutski pripravak prema bilo kojem od prethodnih zahtjeva.
8. Farmaceutski oblik doziranja prema zahtjevu 7, naznačen time da sadrži prvi farmakološki aktivni sastojak u dozi od 10 do 1,200 µg.
9. Farmaceutski oblik doziranja prema zahtjevu 7 ili 8, naznačen time da sadrži drugi farmakološki aktivni sastojak u dozi od 1 mg do 1,000 mg.
10. Komplet naznačen time da sadrži prvi farmaceutski oblik doziranja koji obuhvaća prvi farmakološki aktivni sastojak kako je definiran u zahtjevu 1 ili 2, te drugi farmaceutski oblik doziranja koji sadrži drugi farmakološki aktivni sastojak kako je definiran u zahtjevu 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003937 | 2012-05-18 | ||
| EP13723003.3A EP2849744B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and duloxetine |
| PCT/EP2013/001464 WO2013170965A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171922T1 true HRP20171922T1 (hr) | 2018-02-09 |
Family
ID=48446243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171922TT HRP20171922T1 (hr) | 2012-05-18 | 2017-12-12 | Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-amin i duloksetin |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20130310385A1 (hr) |
| EP (1) | EP2849744B1 (hr) |
| JP (1) | JP6116672B2 (hr) |
| CN (1) | CN104271131A (hr) |
| AU (1) | AU2013262071B2 (hr) |
| BR (1) | BR112014028562A2 (hr) |
| CA (1) | CA2873634A1 (hr) |
| CY (1) | CY1119825T1 (hr) |
| DK (1) | DK2849744T3 (hr) |
| EA (1) | EA027268B1 (hr) |
| ES (1) | ES2660461T3 (hr) |
| HK (1) | HK1204944A1 (hr) |
| HR (1) | HRP20171922T1 (hr) |
| HU (1) | HUE037746T2 (hr) |
| IL (1) | IL235657B (hr) |
| LT (1) | LT2849744T (hr) |
| MX (1) | MX354684B (hr) |
| NO (1) | NO2849744T3 (hr) |
| PL (1) | PL2849744T3 (hr) |
| PT (1) | PT2849744T (hr) |
| RS (1) | RS56856B1 (hr) |
| SI (1) | SI2849744T1 (hr) |
| WO (1) | WO2013170965A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201642853A (zh) | 2015-01-23 | 2016-12-16 | 歌林達有限公司 | 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ） |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS584720A (ja) | 1981-06-26 | 1983-01-11 | ザ・アツプジヨン・カンパニ− | 鎮痛用医薬組成物 |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| ATE46265T1 (de) | 1985-01-23 | 1989-09-15 | Asta Pharma Ag | Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika. |
| ES2098264T3 (es) | 1989-05-22 | 1997-05-01 | Biochemical Veterinary Res | Sales metalicas divalentes de indometacina. |
| US5708035A (en) * | 1991-02-04 | 1998-01-13 | Sepracor Inc. | Methods of use and compositions of R(-) fluoxetine |
| WO1993000895A1 (en) | 1991-07-04 | 1993-01-21 | Taisho Pharmaceutical Co., Ltd. | Analgesic |
| JPH05221857A (ja) | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| WO1994029309A1 (en) | 1993-06-07 | 1994-12-22 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US20030056896A1 (en) | 1995-05-12 | 2003-03-27 | Frank Jao | Effective therapy for epilepsies |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| JP5026635B2 (ja) | 1998-09-10 | 2012-09-12 | ニュコメデ ダンマルク アンパーツセルスカブ | 医薬物質の迅速放出医薬組成物 |
| EP1135121B1 (en) | 1998-11-13 | 2003-03-12 | Eli Lilly And Company | Combination of duloxetine with non-steroidal antiinflammatory drug for treating pain |
| US6117900A (en) | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
| AU2001288110A1 (en) | 2000-09-27 | 2002-04-08 | Takeda Chemical Industries Ltd. | Spiro compounds |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| EP1470126A1 (en) | 2002-01-28 | 2004-10-27 | Pfizer Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| SI1374906T1 (sl) | 2002-06-17 | 2007-10-31 | Chiesi Farma Spa | Postopek za pripravo inkluzijskih spojin piroksakama: beta-ciklodekstrina |
| US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CA2507159A1 (en) * | 2002-11-26 | 2004-06-10 | Alexza Molecular Delivery Corporation | Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| US20040222123A1 (en) | 2003-05-06 | 2004-11-11 | Barr Laboratories, Inc. | Kit for pharmaceuticals |
| CN1245379C (zh) | 2003-10-30 | 2006-03-15 | 曹桂东 | 加巴喷丁的制法 |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| GB0412878D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Use |
| EP1763354A2 (en) * | 2004-06-09 | 2007-03-21 | Pfizer Limited | Use of reboxetine for the treatment of pain |
| CN101198606A (zh) | 2005-06-17 | 2008-06-11 | 辉瑞有限公司 | 作为ORL1-受体拮抗剂的α-(芳基-或杂芳基-甲基-)-β哌啶子基丙酰胺化合物 |
| US8093408B2 (en) * | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
| PL2012763T3 (pl) | 2006-04-28 | 2011-08-31 | Gruenenthal Gmbh | Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylo-propylo)-fenol i NSAID |
| BRPI0710682B8 (pt) | 2006-04-28 | 2021-05-25 | Gruenenthal Gmbh | combinação farmacêutica compreendendo 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol e paracetamol |
| US20080014271A1 (en) | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| JP2008106028A (ja) | 2006-10-26 | 2008-05-08 | Boehringer Ingelheim Internatl Gmbh | 慢性疼痛の治療におけるフリバンセリンの使用 |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| US20080153874A1 (en) | 2006-12-22 | 2008-06-26 | Allergan Inc. | Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain |
| WO2008108639A1 (en) | 2007-03-08 | 2008-09-12 | Avantium Holding B.V. | Co-crystalline forms of carbamazepine |
| EP1977744A1 (en) | 2007-04-03 | 2008-10-08 | Chemo Ibérica, S.A. | Polymorphic Form alpha of (S)-Pregabalin and process for its preparation |
| JP5452494B2 (ja) | 2007-10-09 | 2014-03-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンフォチアミンと１または２種以上の医薬活性剤とを含む神経因性の疼痛状態の処置のための医薬組成物 |
| CN101932316A (zh) * | 2007-12-21 | 2010-12-29 | Paz医药发展有限公司 | 药物制剂及其制备和其在治疗疼痛相关的神经病中的应用 |
| EP2123626A1 (en) | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
| EP2297092A1 (en) | 2008-05-28 | 2011-03-23 | Pliva Hrvatska D.O.O. | Polymorphic and amorphous forms of lacosamide and amorphous compositions |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| KR20110065488A (ko) | 2008-09-05 | 2011-06-15 | 그뤼넨탈 게엠베하 | 6-디메틸아미노메틸-1-(3-메톡시-페닐)-사이클로헥산-1,3-디올 및 ｎｓａｉｄ를 포함하는 약제학적 병용물 |
| US20100069501A1 (en) | 2008-09-05 | 2010-03-18 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and Paracetamol |
| KR101730924B1 (ko) | 2008-09-05 | 2017-04-27 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| DE102009013613A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Trockenverarbeitung von Retigabin |
| ES2536534T3 (es) | 2010-07-30 | 2015-05-26 | Toray Industries, Inc. | Agente terapéutico o agente profiláctico para el dolor neuropático |
| WO2012016703A2 (en) * | 2010-08-04 | 2012-02-09 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| HUE039328T2 (hu) * | 2010-08-04 | 2018-12-28 | Gruenenthal Gmbh | 6'-Fluor-(N-metil- vagy N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro[ciklohexán-1,1'pirano[3,4,B]indol]-4-amin összetételû gyógyszerészeti adagolási forma a neuropátiás fájdalom kezelésére |
| BR112013002696A2 (pt) * | 2010-08-04 | 2016-05-31 | Gruenenthal Gmbh | forma de dosagem farmacêutica compreendendo 6'-fluor-(n-metil- ou n,n-dimetil-)4-fenil-4',9'-diidro-3'h-espiro[cicloexano-1,-1'-pirano[3,4-b]indol]-4 amina 13'' |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,803 patent/US20130310385A1/en not_active Abandoned
- 2013-05-16 MX MX2014012859A patent/MX354684B/es active IP Right Grant
- 2013-05-16 LT LTEP13723003.3T patent/LT2849744T/lt unknown
- 2013-05-16 BR BR112014028562A patent/BR112014028562A2/pt not_active IP Right Cessation
- 2013-05-16 JP JP2015511951A patent/JP6116672B2/ja active Active
- 2013-05-16 DK DK13723003.3T patent/DK2849744T3/en active
- 2013-05-16 WO PCT/EP2013/001464 patent/WO2013170965A1/en active Application Filing
- 2013-05-16 CA CA2873634A patent/CA2873634A1/en not_active Abandoned
- 2013-05-16 EP EP13723003.3A patent/EP2849744B1/en active Active
- 2013-05-16 RS RS20180143A patent/RS56856B1/sr unknown
- 2013-05-16 ES ES13723003.3T patent/ES2660461T3/es active Active
- 2013-05-16 PT PT137230033T patent/PT2849744T/pt unknown
- 2013-05-16 HU HUE13723003A patent/HUE037746T2/hu unknown
- 2013-05-16 EA EA201401269A patent/EA027268B1/ru not_active IP Right Cessation
- 2013-05-16 SI SI201330895T patent/SI2849744T1/en unknown
- 2013-05-16 CN CN201380025639.9A patent/CN104271131A/zh active Pending
- 2013-05-16 PL PL13723003T patent/PL2849744T3/pl unknown
- 2013-05-16 AU AU2013262071A patent/AU2013262071B2/en not_active Ceased
- 2013-05-16 NO NO13723003A patent/NO2849744T3/no unknown
-
2014
- 2014-11-12 IL IL235657A patent/IL235657B/en active IP Right Grant
-
2015
- 2015-06-11 HK HK15105575.5A patent/HK1204944A1/xx not_active IP Right Cessation
-
2016
- 2016-09-22 US US15/272,979 patent/US10328055B2/en not_active Expired - Fee Related
-
2017
- 2017-12-12 HR HRP20171922TT patent/HRP20171922T1/hr unknown
-
2018
- 2018-01-24 CY CY20181100091T patent/CY1119825T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20170065560A1 (en) | 2017-03-09 |
| EA027268B1 (ru) | 2017-07-31 |
| CA2873634A1 (en) | 2013-11-21 |
| HK1204944A1 (en) | 2015-12-11 |
| EP2849744A1 (en) | 2015-03-25 |
| US20130310385A1 (en) | 2013-11-21 |
| LT2849744T (lt) | 2018-02-26 |
| MX354684B (es) | 2018-03-15 |
| AU2013262071B2 (en) | 2018-01-18 |
| WO2013170965A1 (en) | 2013-11-21 |
| DK2849744T3 (en) | 2018-01-22 |
| SI2849744T1 (en) | 2018-01-31 |
| AU2013262071A1 (en) | 2015-01-22 |
| CY1119825T1 (el) | 2018-06-27 |
| PT2849744T (pt) | 2018-02-28 |
| PL2849744T3 (pl) | 2018-06-29 |
| JP6116672B2 (ja) | 2017-04-19 |
| IL235657B (en) | 2018-08-30 |
| NO2849744T3 (hr) | 2018-04-21 |
| RS56856B1 (sr) | 2018-04-30 |
| MX2014012859A (es) | 2015-01-19 |
| US10328055B2 (en) | 2019-06-25 |
| HUE037746T2 (hu) | 2018-09-28 |
| IL235657A0 (en) | 2015-01-29 |
| EP2849744B1 (en) | 2017-11-22 |
| JP2015520154A (ja) | 2015-07-16 |
| ES2660461T3 (es) | 2018-03-22 |
| CN104271131A (zh) | 2015-01-07 |
| EA201401269A1 (ru) | 2016-05-31 |
| BR112014028562A2 (pt) | 2017-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20180904T1 (hr) | Farmaceutski oblik doziranja koji sadrži 6'-fluoro-(n-metil-ili n,n-dimetil-)-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje neuropatske boli | |
| HRP20171693T1 (hr) | Farmaceutski pripravak koji sadrži (1r, 4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano-[3,4,b]indol]-4-amin i ibuprofen | |
| JP2015515475A5 (hr) | ||
| AR075735A1 (es) | Composiciones farmaceuticas de liberacion inmediata que comprenden oxicodona y naloxona. uso | |
| JP2013528600A5 (hr) | ||
| HRP20230272T1 (hr) | Postupci za liječenje cistične fibroze | |
| JP2015038135A5 (hr) | ||
| HRP20151337T1 (hr) | Farmaceutski oblik doziranja koji sadrži 6'-fluoro-(n-metil- ili n,n-dimetil)-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin | |
| RU2014141362A (ru) | Комбинированная терапия пролиферативных нарушений | |
| HRP20171743T1 (hr) | Sastavi i postupci za savladavanje otpornosti na tramadol | |
| RU2018135967A (ru) | Интраназальные фармацевтические композиции на основе бензодиазепина | |
| JP2012236834A5 (hr) | ||
| WO2011159100A2 (ko) | 항암 활성을 나타내는 약제학적 조성물 | |
| JP2013516493A5 (hr) | ||
| RU2014129508A (ru) | Новая комбинация | |
| HRP20191322T1 (hr) | Antitumorska kombinacija koja sadži kabazitaksel i cisplatin | |
| HRP20170517T1 (hr) | Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikoheksan-1,1'-pirano[3,4,b]indol]-4-amin i antikonvulziv | |
| HRP20171708T1 (hr) | FARMACEUTSKI PRIPRAVAK KOJI SADRŽI (1R,4R)-6'-FLUORO-N,N-DIMETIL-4-FENIL-4',9'-DIHIDRO-3'H-SPIRO[CIKLOHEKSAN-1,1'-PIRANO [3,4,b]INDOL]-4-AMIN I GABAPENTINOID | |
| WO2012064159A3 (ko) | 항암용 조성물 | |
| HRP20171725T1 (hr) | FARMACEUTSKI PRIPRAVAK KOJI SADRŽI (1R,4R)-6'-FLUORO-N,N-DIMETIL-4-FENIL-4',9'-DIHIDRO-3'H-SPIRO[CIKLOHEKSAN-1,1'-PIRANO [3,4,b]INDOL]-4-AMIN I NSAR | |
| HRP20171922T1 (hr) | Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-amin i duloksetin | |
| HRP20151340T1 (hr) | Derivati tieno[2,3-d] pirimidina i njihova primjena u lijeäśenju aritmije | |
| HRP20231448T1 (hr) | Primjena delgocitiniba za liječenje kroničnog ekcema ruku | |
| HRP20171927T1 (hr) | Farmaceutski pripravak koji sadrži (1r,4r)-6'-fluor-n,n-dimetil-4-fenil-4',9'-diidro-3'h-spiro[cikloheksan-1,1'-pirano-[3,4,b]indol]-4-amin i acetilsalicilnu kiselinu | |
| JP2012041314A5 (hr) |