MX354684B - Composición farmacéutica que comprende (1r,4r)-6'-fluoro-n,n-dimet il-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b] indol]-4-amina y antidepresivos. - Google Patents

Composición farmacéutica que comprende (1r,4r)-6'-fluoro-n,n-dimet il-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b] indol]-4-amina y antidepresivos.

Info

Publication number
MX354684B
MX354684B MX2014012859A MX2014012859A MX354684B MX 354684 B MX354684 B MX 354684B MX 2014012859 A MX2014012859 A MX 2014012859A MX 2014012859 A MX2014012859 A MX 2014012859A MX 354684 B MX354684 B MX 354684B
Authority
MX
Mexico
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
MX2014012859A
Other languages
English (en)
Other versions
MX2014012859A (es
Inventor
Linz Klaus
Christoph Thomas
Frosch Stefanie
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014012859A publication Critical patent/MX2014012859A/es
Publication of MX354684B publication Critical patent/MX354684B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con una composición farmacéutica que comprende un primer ingrediente farmacológicamente activo seleccionado de (1r,4r)-6´-fluoro-N,N-di metil-4-fenil-4´,9´-dihidro-3´H-espiro[ciclohexan-1,1´-pirano[3,4 ,b]indol]-4-amina y las sales fisiológicamente aceptables del mismo, y un segundo ingrediente farmacológicamente activo que es un antidepresivo.
MX2014012859A 2012-05-18 2013-05-16 Composición farmacéutica que comprende (1r,4r)-6'-fluoro-n,n-dimet il-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b] indol]-4-amina y antidepresivos. MX354684B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003937 2012-05-18
PCT/EP2013/001464 WO2013170965A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants

Publications (2)

Publication Number Publication Date
MX2014012859A MX2014012859A (es) 2015-01-19
MX354684B true MX354684B (es) 2018-03-15

Family

ID=48446243

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014012859A MX354684B (es) 2012-05-18 2013-05-16 Composición farmacéutica que comprende (1r,4r)-6'-fluoro-n,n-dimet il-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b] indol]-4-amina y antidepresivos.

Country Status (22)

Country Link
US (2) US20130310385A1 (es)
EP (1) EP2849744B1 (es)
JP (1) JP6116672B2 (es)
CN (1) CN104271131A (es)
AU (1) AU2013262071B2 (es)
BR (1) BR112014028562A2 (es)
CA (1) CA2873634A1 (es)
CY (1) CY1119825T1 (es)
DK (1) DK2849744T3 (es)
EA (1) EA027268B1 (es)
ES (1) ES2660461T3 (es)
HR (1) HRP20171922T1 (es)
HU (1) HUE037746T2 (es)
IL (1) IL235657B (es)
LT (1) LT2849744T (es)
MX (1) MX354684B (es)
NO (1) NO2849744T3 (es)
PL (1) PL2849744T3 (es)
PT (1) PT2849744T (es)
RS (1) RS56856B1 (es)
SI (1) SI2849744T1 (es)
WO (1) WO2013170965A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246418C1 (ru) * 2003-06-19 2005-02-20 Общество с ограниченной ответственностью "ТехноМастер" Усилитель щитка передка кузова легкового автомобиля
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA

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Also Published As

Publication number Publication date
AU2013262071A1 (en) 2015-01-22
US10328055B2 (en) 2019-06-25
EP2849744A1 (en) 2015-03-25
CA2873634A1 (en) 2013-11-21
PT2849744T (pt) 2018-02-28
CY1119825T1 (el) 2018-06-27
SI2849744T1 (en) 2018-01-31
US20170065560A1 (en) 2017-03-09
HK1204944A1 (en) 2015-12-11
EP2849744B1 (en) 2017-11-22
HUE037746T2 (hu) 2018-09-28
BR112014028562A2 (pt) 2017-06-27
MX2014012859A (es) 2015-01-19
ES2660461T3 (es) 2018-03-22
WO2013170965A1 (en) 2013-11-21
HRP20171922T1 (hr) 2018-02-09
CN104271131A (zh) 2015-01-07
PL2849744T3 (pl) 2018-06-29
NO2849744T3 (es) 2018-04-21
RS56856B1 (sr) 2018-04-30
EA027268B1 (ru) 2017-07-31
US20130310385A1 (en) 2013-11-21
LT2849744T (lt) 2018-02-26
JP2015520154A (ja) 2015-07-16
AU2013262071B2 (en) 2018-01-18
EA201401269A1 (ru) 2016-05-31
IL235657B (en) 2018-08-30
IL235657A0 (en) 2015-01-29
JP6116672B2 (ja) 2017-04-19
DK2849744T3 (en) 2018-01-22

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