CY1119692T1 - Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ - Google Patents

Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ

Info

Publication number
CY1119692T1
CY1119692T1 CY20171101323T CY171101323T CY1119692T1 CY 1119692 T1 CY1119692 T1 CY 1119692T1 CY 20171101323 T CY20171101323 T CY 20171101323T CY 171101323 T CY171101323 T CY 171101323T CY 1119692 T1 CY1119692 T1 CY 1119692T1
Authority
CY
Cyprus
Prior art keywords
spiro
fluoro
dimethyl
pharmaceutical composition
acid
Prior art date
Application number
CY20171101323T
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Klaus Schiene
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1119692T1 publication Critical patent/CY1119692T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά μία φαρμακευτική σύνθεση η οποία περιλαμβάνει ένα πρώτο φαρμακολογικά δραστικό συστατικό το οποίο επιλέγεται από (1r,4r)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3Ή-σπιρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμίνη και τα φυσιολογικά αποδεκτά άλατα αυτής και ένα δεύτερο φαρμακολογικά δραστικό συστατικό το οποίο είναι ένα συστατικό σαλικυλικού οξέος που επιλέγεται από την ομάδα η οποία αποτελείται από ακετυλοσαλικυλικό οξύ, σαλικυλικό οξύ, σαλικυλαμίδιο, εθενζαμίδιο, σαλσαλάτη, διπυροκετύλιο, βενοριλάτη, διφλουνιζάλη, γκουακετισάλη και τα φυσιολογικά αποδεκτά άλατα αυτών.
CY20171101323T 2012-05-18 2017-12-18 Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ CY1119692T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003936 2012-05-18
EP13723673.3A EP2852386B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and acetylsalicylic acid
PCT/EP2013/001467 WO2013170968A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component

Publications (1)

Publication Number Publication Date
CY1119692T1 true CY1119692T1 (el) 2018-04-04

Family

ID=48468207

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101323T CY1119692T1 (el) 2012-05-18 2017-12-18 Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ

Country Status (23)

Country Link
US (1) US9855286B2 (el)
EP (1) EP2852386B1 (el)
JP (1) JP6116675B2 (el)
CN (1) CN104284661A (el)
AU (1) AU2013262074B2 (el)
BR (1) BR112014028564A2 (el)
CA (1) CA2873640A1 (el)
CY (1) CY1119692T1 (el)
DK (1) DK2852386T3 (el)
EA (1) EA026642B1 (el)
ES (1) ES2654146T3 (el)
HK (1) HK1204941A1 (el)
HR (1) HRP20171927T1 (el)
HU (1) HUE035930T2 (el)
IL (1) IL235656B (el)
LT (1) LT2852386T (el)
MX (1) MX352595B (el)
NO (1) NO2852386T3 (el)
PL (1) PL2852386T3 (el)
PT (1) PT2852386T (el)
RS (1) RS56674B1 (el)
SI (1) SI2852386T1 (el)
WO (1) WO2013170968A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3247352B1 (en) 2015-01-23 2020-06-24 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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Also Published As

Publication number Publication date
RS56674B1 (sr) 2018-03-30
JP2015516448A (ja) 2015-06-11
DK2852386T3 (en) 2018-01-08
EA026642B1 (ru) 2017-04-28
EP2852386B1 (en) 2017-11-15
PL2852386T3 (pl) 2018-02-28
BR112014028564A2 (pt) 2017-06-27
EP2852386A1 (en) 2015-04-01
NO2852386T3 (el) 2018-04-14
LT2852386T (lt) 2018-01-10
EA201401267A1 (ru) 2016-05-31
HRP20171927T1 (hr) 2018-01-26
JP6116675B2 (ja) 2017-04-19
AU2013262074B2 (en) 2018-01-18
ES2654146T3 (es) 2018-02-12
US20130317076A1 (en) 2013-11-28
HUE035930T2 (hu) 2018-06-28
IL235656B (en) 2018-08-30
MX352595B (es) 2017-11-30
AU2013262074A1 (en) 2015-01-22
MX2014012765A (es) 2014-11-21
WO2013170968A1 (en) 2013-11-21
CA2873640A1 (en) 2013-11-21
US9855286B2 (en) 2018-01-02
CN104284661A (zh) 2015-01-14
PT2852386T (pt) 2018-01-04
IL235656A0 (en) 2015-01-29
HK1204941A1 (en) 2015-12-11
SI2852386T1 (en) 2018-04-30

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