CN104168897B - 用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 - Google Patents
用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12000743.0 | 2012-02-03 | ||
| EP12000743 | 2012-02-03 | ||
| PCT/EP2013/051979 WO2013113857A1 (en) | 2012-02-03 | 2013-02-01 | (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104168897A CN104168897A (zh) | 2014-11-26 |
| CN104168897B true CN104168897B (zh) | 2016-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380007809.0A Expired - Fee Related CN104168897B (zh) | 2012-02-03 | 2013-02-01 | 用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20130202701A1 (enExample) |
| EP (1) | EP2809320B1 (enExample) |
| JP (1) | JP6126134B2 (enExample) |
| KR (1) | KR102061482B1 (enExample) |
| CN (1) | CN104168897B (enExample) |
| AU (1) | AU2013214223B2 (enExample) |
| BR (1) | BR112014019136A8 (enExample) |
| CA (1) | CA2863572C (enExample) |
| CY (1) | CY1118799T1 (enExample) |
| DK (1) | DK2809320T3 (enExample) |
| EA (1) | EA025500B1 (enExample) |
| ES (1) | ES2629211T3 (enExample) |
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| US5900420A (en) * | 1997-06-19 | 1999-05-04 | Cole; William L. | Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| BRPI0509377A (pt) * | 2004-03-29 | 2007-09-11 | Pfizer | compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1 |
| MX2008015048A (es) * | 2006-05-31 | 2008-12-10 | Sepracor Inc | Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida. |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
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| CN1735619A (zh) * | 2002-11-11 | 2006-02-15 | 格吕伦塔尔有限公司 | 螺环环己烷衍生物 |
Non-Patent Citations (2)
| Title |
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| 慢性疲劳综合征的临床特征与研究进展;王斌等;《中国临床康复》;20041215;第8卷(第35期);第8078-8081页 * |
| 纤维肌痛综合征的研究进展;崔阳等;《中华风湿病学杂志》;20060228;第10卷(第2期);第114-116页 * |
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| HK1199218A1 (en) | 2015-06-26 |
| AU2013214223B2 (en) | 2017-03-23 |
| US20130202701A1 (en) | 2013-08-08 |
| CN104168897A (zh) | 2014-11-26 |
| CA2863572C (en) | 2019-08-27 |
| EA201400857A1 (ru) | 2015-01-30 |
| EA025500B1 (ru) | 2016-12-30 |
| ES2629211T3 (es) | 2017-08-07 |
| JP6126134B2 (ja) | 2017-05-10 |
| CA2863572A1 (en) | 2013-08-08 |
| KR102061482B1 (ko) | 2020-01-03 |
| KR20140130695A (ko) | 2014-11-11 |
| NZ629800A (en) | 2016-06-24 |
| ZA201406447B (en) | 2016-02-24 |
| EP2809320A1 (en) | 2014-12-10 |
| IL233871B (en) | 2018-06-28 |
| PT2809320T (pt) | 2017-06-30 |
| SI2809320T1 (sl) | 2017-07-31 |
| WO2013113857A1 (en) | 2013-08-08 |
| BR112014019136A2 (enExample) | 2017-06-20 |
| IL233871A0 (en) | 2014-09-30 |
| MX353740B (es) | 2018-01-26 |
| PL2809320T3 (pl) | 2017-09-29 |
| DK2809320T3 (en) | 2017-05-15 |
| RS56097B1 (sr) | 2017-10-31 |
| MX2014008865A (es) | 2014-08-27 |
| BR112014019136A8 (pt) | 2017-07-11 |
| EP2809320B1 (en) | 2017-03-22 |
| CY1118799T1 (el) | 2018-01-10 |
| AU2013214223A1 (en) | 2014-09-18 |
| HRP20170581T1 (hr) | 2017-06-16 |
| JP2015505553A (ja) | 2015-02-23 |
| LT2809320T (lt) | 2017-05-25 |
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