IL233871B - -6'(r4,r1)fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl 4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4,3,b]indole]-4-amine for the treatment of fibromyalgia and chronic fatigue syndrome - Google Patents

-6'(r4,r1)fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl 4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4,3,b]indole]-4-amine for the treatment of fibromyalgia and chronic fatigue syndrome

Info

Publication number
IL233871B
IL233871B IL233871A IL23387114A IL233871B IL 233871 B IL233871 B IL 233871B IL 233871 A IL233871 A IL 233871A IL 23387114 A IL23387114 A IL 23387114A IL 233871 B IL233871 B IL 233871B
Authority
IL
Israel
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
IL233871A
Other languages
English (en)
Hebrew (he)
Other versions
IL233871A0 (en
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of IL233871A0 publication Critical patent/IL233871A0/en
Publication of IL233871B publication Critical patent/IL233871B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
IL233871A 2012-02-03 2014-07-30 -6'(r4,r1)fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl 4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4,3,b]indole]-4-amine for the treatment of fibromyalgia and chronic fatigue syndrome IL233871B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12000743 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Publications (2)

Publication Number Publication Date
IL233871A0 IL233871A0 (en) 2014-09-30
IL233871B true IL233871B (en) 2018-06-28

Family

ID=47628188

Family Applications (1)

Application Number Title Priority Date Filing Date
IL233871A IL233871B (en) 2012-02-03 2014-07-30 -6'(r4,r1)fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl 4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4,3,b]indole]-4-amine for the treatment of fibromyalgia and chronic fatigue syndrome

Country Status (23)

Country Link
US (1) US20130202701A1 (enExample)
EP (1) EP2809320B1 (enExample)
JP (1) JP6126134B2 (enExample)
KR (1) KR102061482B1 (enExample)
CN (1) CN104168897B (enExample)
AU (1) AU2013214223B2 (enExample)
BR (1) BR112014019136A8 (enExample)
CA (1) CA2863572C (enExample)
CY (1) CY1118799T1 (enExample)
DK (1) DK2809320T3 (enExample)
EA (1) EA025500B1 (enExample)
ES (1) ES2629211T3 (enExample)
HR (1) HRP20170581T1 (enExample)
IL (1) IL233871B (enExample)
LT (1) LT2809320T (enExample)
MX (1) MX353740B (enExample)
NZ (1) NZ629800A (enExample)
PL (1) PL2809320T3 (enExample)
PT (1) PT2809320T (enExample)
RS (1) RS56097B1 (enExample)
SI (1) SI2809320T1 (enExample)
WO (1) WO2013113857A1 (enExample)
ZA (1) ZA201406447B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
BRPI0509377A (pt) * 2004-03-29 2007-09-11 Pfizer compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1
MX2008015048A (es) * 2006-05-31 2008-12-10 Sepracor Inc Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida.
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Also Published As

Publication number Publication date
HK1199218A1 (en) 2015-06-26
AU2013214223B2 (en) 2017-03-23
US20130202701A1 (en) 2013-08-08
CN104168897A (zh) 2014-11-26
CA2863572C (en) 2019-08-27
EA201400857A1 (ru) 2015-01-30
EA025500B1 (ru) 2016-12-30
ES2629211T3 (es) 2017-08-07
JP6126134B2 (ja) 2017-05-10
CA2863572A1 (en) 2013-08-08
KR102061482B1 (ko) 2020-01-03
KR20140130695A (ko) 2014-11-11
NZ629800A (en) 2016-06-24
ZA201406447B (en) 2016-02-24
EP2809320A1 (en) 2014-12-10
PT2809320T (pt) 2017-06-30
SI2809320T1 (sl) 2017-07-31
WO2013113857A1 (en) 2013-08-08
BR112014019136A2 (enExample) 2017-06-20
IL233871A0 (en) 2014-09-30
MX353740B (es) 2018-01-26
PL2809320T3 (pl) 2017-09-29
DK2809320T3 (en) 2017-05-15
RS56097B1 (sr) 2017-10-31
MX2014008865A (es) 2014-08-27
BR112014019136A8 (pt) 2017-07-11
EP2809320B1 (en) 2017-03-22
CY1118799T1 (el) 2018-01-10
CN104168897B (zh) 2016-09-28
AU2013214223A1 (en) 2014-09-18
HRP20170581T1 (hr) 2017-06-16
JP2015505553A (ja) 2015-02-23
LT2809320T (lt) 2017-05-25

Similar Documents

Publication Publication Date Title
IL230331B (en) (r1, 4r)-6' fluoro-n, n--dimethyl-4-phenyl-4', 9'-dihydro-3' h-spiro[cyclohexane-1,1'-pyrano[4,3,b] Crystalline indole]4–amine
PT2849745T (pt) Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e ibuprofeno
IL235654A0 (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] Indole] – 4 – amine and anticonvulsant drug
IL235658A (en) Pharmaceutical Composition Containing (1r, 4r) - 6 '- Fluoro - n, n - Dimethyl - 4 - Phenyl - 4', 9 '- Dihydro - 3'h - Spiro [Cyclohexane - 1, 1' - Pirano [3, 4 , b] indole] - 4 - amine and gabapentinoid
IL233048A0 (en) Solid forms of (r4,r1)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4, 3,b]indole]–4–amine hydrochloride
IL235657A0 (en) Pharmacy device containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and antidepressants
IL235653B (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and a non-steroidal anti-rheumatic drug
IL235652B (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro -3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and oxicam
IL233871B (en) -6'(r4,r1)fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl 4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4,3,b]indole]-4-amine for the treatment of fibromyalgia and chronic fatigue syndrome
IL235651A0 (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] Indole] - 4 - amine and paracetamol or propacetamol
HUE035930T2 (hu) (1R,4R)-6'-fluor-N,N-dimetil-4-fenil-4',9'-dihidro-3'H-spiro [ciklohexán-l,l'-pirano-[3,4,B]indol]-4-amint és acetilszalicilsavat tartalmazó gyógyászati készítmény

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed