NZ629800A - (1r,4r)-6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro-[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome - Google Patents

(1r,4r)-6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro-[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Info

Publication number
NZ629800A
NZ629800A NZ629800A NZ62980013A NZ629800A NZ 629800 A NZ629800 A NZ 629800A NZ 629800 A NZ629800 A NZ 629800A NZ 62980013 A NZ62980013 A NZ 62980013A NZ 629800 A NZ629800 A NZ 629800A
Authority
NZ
New Zealand
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
NZ629800A
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Petra Bloms-Funke
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of NZ629800A publication Critical patent/NZ629800A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
NZ629800A 2012-02-03 2013-02-01 (1r,4r)-6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro-[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome NZ629800A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12000743 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Publications (1)

Publication Number Publication Date
NZ629800A true NZ629800A (en) 2016-06-24

Family

ID=47628188

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ629800A NZ629800A (en) 2012-02-03 2013-02-01 (1r,4r)-6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro-[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Country Status (23)

Country Link
US (1) US20130202701A1 (enExample)
EP (1) EP2809320B1 (enExample)
JP (1) JP6126134B2 (enExample)
KR (1) KR102061482B1 (enExample)
CN (1) CN104168897B (enExample)
AU (1) AU2013214223B2 (enExample)
BR (1) BR112014019136A8 (enExample)
CA (1) CA2863572C (enExample)
CY (1) CY1118799T1 (enExample)
DK (1) DK2809320T3 (enExample)
EA (1) EA025500B1 (enExample)
ES (1) ES2629211T3 (enExample)
HR (1) HRP20170581T1 (enExample)
IL (1) IL233871B (enExample)
LT (1) LT2809320T (enExample)
MX (1) MX353740B (enExample)
NZ (1) NZ629800A (enExample)
PL (1) PL2809320T3 (enExample)
PT (1) PT2809320T (enExample)
RS (1) RS56097B1 (enExample)
SI (1) SI2809320T1 (enExample)
WO (1) WO2013113857A1 (enExample)
ZA (1) ZA201406447B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
BRPI0509377A (pt) * 2004-03-29 2007-09-11 Pfizer compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1
MX2008015048A (es) * 2006-05-31 2008-12-10 Sepracor Inc Tratamiento contra trastornos de dolor con trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina y su formamida.
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Also Published As

Publication number Publication date
HK1199218A1 (en) 2015-06-26
AU2013214223B2 (en) 2017-03-23
US20130202701A1 (en) 2013-08-08
CN104168897A (zh) 2014-11-26
CA2863572C (en) 2019-08-27
EA201400857A1 (ru) 2015-01-30
EA025500B1 (ru) 2016-12-30
ES2629211T3 (es) 2017-08-07
JP6126134B2 (ja) 2017-05-10
CA2863572A1 (en) 2013-08-08
KR102061482B1 (ko) 2020-01-03
KR20140130695A (ko) 2014-11-11
ZA201406447B (en) 2016-02-24
EP2809320A1 (en) 2014-12-10
IL233871B (en) 2018-06-28
PT2809320T (pt) 2017-06-30
SI2809320T1 (sl) 2017-07-31
WO2013113857A1 (en) 2013-08-08
BR112014019136A2 (enExample) 2017-06-20
IL233871A0 (en) 2014-09-30
MX353740B (es) 2018-01-26
PL2809320T3 (pl) 2017-09-29
DK2809320T3 (en) 2017-05-15
RS56097B1 (sr) 2017-10-31
MX2014008865A (es) 2014-08-27
BR112014019136A8 (pt) 2017-07-11
EP2809320B1 (en) 2017-03-22
CY1118799T1 (el) 2018-01-10
CN104168897B (zh) 2016-09-28
AU2013214223A1 (en) 2014-09-18
HRP20170581T1 (hr) 2017-06-16
JP2015505553A (ja) 2015-02-23
LT2809320T (lt) 2017-05-25

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