PT2849745T - Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e ibuprofeno - Google Patents

Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e ibuprofeno

Info

Publication number
PT2849745T
PT2849745T PT137236725T PT13723672T PT2849745T PT 2849745 T PT2849745 T PT 2849745T PT 137236725 T PT137236725 T PT 137236725T PT 13723672 T PT13723672 T PT 13723672T PT 2849745 T PT2849745 T PT 2849745T
Authority
PT
Portugal
Prior art keywords
pyrano
indol
ibuprofen
spiro
dihydro
Prior art date
Application number
PT137236725T
Other languages
English (en)
Inventor
Frosch Stefanie
Schiene Klaus
Linz Klaus
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of PT2849745T publication Critical patent/PT2849745T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT137236725T 2012-05-18 2013-05-16 Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e ibuprofeno PT2849745T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12003935 2012-05-18

Publications (1)

Publication Number Publication Date
PT2849745T true PT2849745T (pt) 2018-02-07

Family

ID=48468206

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137236725T PT2849745T (pt) 2012-05-18 2013-05-16 Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e ibuprofeno

Country Status (23)

Country Link
US (2) US9320729B2 (pt)
EP (1) EP2849745B1 (pt)
JP (1) JP6116674B2 (pt)
CN (1) CN104284659A (pt)
AU (1) AU2013262073B2 (pt)
BR (1) BR112014028571A2 (pt)
CA (1) CA2873656A1 (pt)
CY (1) CY1119786T1 (pt)
DK (1) DK2849745T3 (pt)
EA (1) EA028200B1 (pt)
ES (1) ES2658216T3 (pt)
HK (1) HK1204942A1 (pt)
HR (1) HRP20171693T1 (pt)
HU (1) HUE035112T2 (pt)
IL (1) IL235655B (pt)
LT (1) LT2849745T (pt)
MX (1) MX354687B (pt)
NO (1) NO2849745T3 (pt)
PL (1) PL2849745T3 (pt)
PT (1) PT2849745T (pt)
RS (1) RS56771B1 (pt)
SI (1) SI2849745T1 (pt)
WO (1) WO2013170967A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール

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Also Published As

Publication number Publication date
PL2849745T3 (pl) 2018-04-30
US20130324581A1 (en) 2013-12-05
CY1119786T1 (el) 2018-06-27
US20160199349A1 (en) 2016-07-14
US10076510B2 (en) 2018-09-18
EP2849745B1 (en) 2017-11-01
MX354687B (es) 2018-03-15
RS56771B1 (sr) 2018-04-30
HUE035112T2 (en) 2018-05-02
AU2013262073B2 (en) 2018-01-18
US9320729B2 (en) 2016-04-26
MX2014013148A (es) 2015-01-19
IL235655B (en) 2018-08-30
JP2015516447A (ja) 2015-06-11
AU2013262073A1 (en) 2015-01-22
EP2849745A1 (en) 2015-03-25
CN104284659A (zh) 2015-01-14
EA028200B1 (ru) 2017-10-31
HRP20171693T1 (hr) 2017-12-15
WO2013170967A1 (en) 2013-11-21
EA201401266A1 (ru) 2016-05-31
BR112014028571A2 (pt) 2017-06-27
CA2873656A1 (en) 2013-11-21
IL235655A0 (en) 2015-01-29
DK2849745T3 (en) 2017-12-04
LT2849745T (lt) 2018-01-25
SI2849745T1 (en) 2018-03-30
NO2849745T3 (pt) 2018-03-31
JP6116674B2 (ja) 2017-04-19
ES2658216T3 (es) 2018-03-08
HK1204942A1 (en) 2015-12-11

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